WordNet
- secure against; "immune from taxation as long as he resided in Bermuda"; "immune from criminal prosecution"
- a person who is immune to a particular infection
- relating to or conferring immunity (to disease or infection) (同)resistant
- (usually followed by `to'
- relating to the condition of immunity; "the immune system"
- a result; "this situation developed in response to events in Africa"
- a phrase recited or sung by the congregation following a versicle by the priest or minister
- the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
- relating to cells; "cellular walls"; "cellular physiology"
- characterized by or divided into or containing cells or compartments (the smallest organizational or structural unit of an organism or organization); "the cellular construction of a beehive"; "any effective opposition to a totalitarian regime must be secretive and cellular"
PrepTutorEJDIC
- 免疫の / 《補語にのみ用いて》(影響・攻撃・義務・税などを)免れている《+『against』(『from, to』)+『名』》
- 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
- 細胞の,細胞質の,細胞状の / 小室(小区画)のある / (生地など)目の透いている
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/05 05:25:59」(JST)
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Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Historically, the immune system was separated into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells. CD4 cells or helper T cells provide protection against different pathogens. Cytotoxic T cells cause death by apoptosis without using cytokines, therefore in cell mediated immunity cytokines are not always present.
The innate immune system and the adaptive immune system each comprise both humoral and cell-mediated components.
Cellular immunity protects the body by:
- activating antigen-specific cytotoxic T-lymphocytes that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
- activating macrophages and natural killer cells, enabling them to destroy pathogens; and
- stimulating cells to secrete a variety of cytokines that influence the function of other cells involved in adaptive immune responses and innate immune responses.
Cell-mediated immunity is directed primarily at microbes that survive in phagocytes and microbes that infect non-phagocytic cells. It is most effective in removing virus-infected cells, but also participates in defending against fungi, protozoans, cancers, and intracellular bacteria. It also plays a major role in transplant rejection.
Myeloid lineage - Blood (WBC and RBC)
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Cellular/
HSCs |
Myeloid/
CFU-GEMM |
CFU-GM |
CFU-G:
Granulocytes |
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CFU-M:
Monocytes/
MPS |
Macrophages |
- Histiocytes
- Kupffer cells
- Alveolar macrophage
- Microglia
- Osteoclasts
- Epithelioid cells
- giant cells
- Langhans giant cells, Foreign-body giant cell
- Touton giant cells
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CFU-DL |
- Dendritic cells
- Langerhans cell
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Common |
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CFU-Baso |
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CFU-Eos |
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MEP |
CFU-Meg |
- Megakaryoblast (* primitive Kacheshmarova's cell)
- Megakaryocyte (Kacheshmarova's cell)
- Platelets
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CFU-E |
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CFU-Mast |
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Noncellular |
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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Immunology: Lymphocytic adaptive immune system and complement
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Lymphoid |
Antigens
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- Antigen presentation/Professional APCs: Dendritic cell
- Macrophage
- B cell
- Immunogen
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Antibodies
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- Antibody
- Monoclonal antibodies
- Polyclonal antibodies
- Autoantibody
- Microantibody
- Polyclonal B cell response
- Allotype
- Isotype
- Idiotype
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Immunity vs.
tolerance
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- action: Immunity
- Autoimmunity
- Alloimmunity
- Allergy
- Hypersensitivity
- Inflammation
- Cross-reactivity
- inaction: Tolerance
- Central
- Peripheral
- Clonal anergy
- Clonal deletion
- Tolerance in pregnancy
- Immunodeficiency
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Immunogenetics
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- Affinity maturation (Somatic hypermutation
- Clonal selection)
- V(D)J recombination
- Junctional diversity
- Immunoglobulin class switching
- MHC/HLA
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Lymphocytes |
- Cellular (T cell)
- Humoral (B cell)
- NK cell
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Substances |
- Cytokines
- Opsonin
- Cytolysin
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Complement |
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cell/phys/auag/auab/comp, igrc
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Immune disorders: hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
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Autoimmune |
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Type II/ADCC
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Foreign |
- Pernicious anemia
- Hemolytic disease of the newborn
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Autoimmune |
Cytotoxic |
- Autoimmune hemolytic anemia
- Idiopathic thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
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"Type 5"/receptor |
- Graves' disease
- Myasthenia gravis
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Type III
(Immune complex) |
Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
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Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
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Type IV/cell-mediated
(T cells) |
Foreign |
- Allergic contact dermatitis
- Mantoux test
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Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Guillain–Barré syndrome
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
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GVHD |
- Transfusion-associated graft versus host disease
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Unknown/
multiple |
Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
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Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
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cell/phys/auag/auab/comp, igrc
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UpToDate Contents
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English Journal
- Proteasome modulator 9 is linked to microvascular pathology of T2D.
- Gragnoli C.SourceDepartment of Medicine, Cellular & Molecular Physiology, Biostatistics, Laboratory of Molecular Genetics of Monogenic and Complex Disorders, M. S. Hershey Medical Center; Penn State University College of Medicine, Hershey, Pennsylvania; Bios Biotech Multi-Diagnostic Health Center, Molecular Biology Laboratory, Rome, Italy; Center for Biotechnology and Department of Biology, Temple University's College of Science & Technology, Philadelphia, Pennsylvania. claudia.gragnoli@gmail.com.
- Journal of cellular physiology.J Cell Physiol.2012 Aug;227(8):3116-8. doi: 10.1002/jcp.23063.
- The locus 12q24 is linked to type 2 diabetes (T2D) and to changes in retinal vascular caliber in Caucasians. Proteasome Modulator 9 gene (PSMD9) lies in the 12q24 locus and is implicated in diabetes onset and in degradation of intracellular proteins in antigenic peptides in the immune response to an
- PMID 22015693
Japanese Journal
- Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo
- Subacute ruminal acidosis (SARA) challenge, ruminal condition and cellular immunity in cattle
- Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice
Related Links
- cellular immune response n. See cell-mediated immune response. ... A project communique said these experts would pursue "innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular ...
- The Role of Cell-Mediated Immunity The cellular immune response involves the adaptive immune response in which antigen-specific T cells play the main role in controlling and eliminating the infection. This is a type of adaptive ...
★リンクテーブル★
[★]
- 英
- cell mediated immunological reaction, cell-mediated immunological react, cell-mediated immunological reaction, cell mediated immune reaction, cell mediated immune response, cellular immune response, cellular immunoreaction
[★]
- 関
- immunisation、immunise、immunity、immunization、immunize、immuno、immunologic
[★]
[★]
- 関
- cell、cell-mediated、cellularity、cyto