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- cefuzonam sodium
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/25 22:46:25」(JST)
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Cefuzonam
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Systematic (IUPAC) name |
(6R,7R)-7-([(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino)-8-oxo-3-(thiadiazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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Clinical data |
Legal status |
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Identifiers |
CAS Number |
82219-78-1 Y |
ATC code |
None |
PubChem |
CID 6336505 |
ChemSpider |
4891670 N |
UNII |
860MT00T7T Y |
KEGG |
D03432 Y |
ChEMBL |
CHEMBL1689069 N |
Chemical data |
Formula |
C16H15N7O5S4 |
Molar mass |
513.59 g/mol |
SMILES
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CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CSC4=CN=NS4)C(=O)O
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InChI
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InChI=1S/C16H15N7O5S4/c1-28-21-9(7-5-31-16(17)19-7)12(24)20-10-13(25)23-11(15(26)27)6(4-30-14(10)23)3-29-8-2-18-22-32-8/h2,5,10,14H,3-4H2,1H3,(H2,17,19)(H,20,24)(H,26,27)/b21-9-/t10-,14-/m1/s1 N
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Key:CXHKZHZLDMQGFF-ZSDSSEDPSA-N N
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NY (what is this?) (verify) |
Cefuzonam (INN) is a second-generation cephalosporin antibiotic.
References
- Hara K, Matsumoto F (December 1987). "[New antimicrobial agent series XXVIII: cefuzonam]". Jpn J Antibiot (in Japanese) 40 (12): 1953–63. PMID 3329242.
Antibacterials: cell envelope antibiotics (J01C-J01D)
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Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(Inhibit PBP
cross-links) |
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Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Gramicidin
- Isoniazid
- Teixobactin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- The excretion of cephem antibiotics into saliva is inversely associated with their plasma protein-binding activities.
- Hamada T, Ueta E, Kodama H, Osaki T.SourceDepartment of Oral Surgery, Kochi Medical School, Nankoku-city, Kochi, Japan. a/o/o@liml.ocn.ne.jp
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.J Oral Pathol Med.2002 Feb;31(2):109-16.
- BACKGROUND: The excretion of medicated drugs into saliva may disturb the oral environment and antibiotic excretion into saliva appears to be regulated by many factors that have not been fully explored.METHODS: Excretion of four cephem antibiotics into saliva was examined in healthy volunteers and ra
- PMID 11896833
- Cloning and sequencing of the gene encoding Toho-2, a class A beta-lactamase preferentially inhibited by tazobactam.
- Ma L, Ishii Y, Ishiguro M, Matsuzawa H, Yamaguchi K.SourceDepartment of Microbiology, Toho University School of Medicine, Tokyo, Japan.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.1998 May;42(5):1181-6.
- Escherichia coli TUM1083, which is resistant to ampicillin, carbenicillin, cephaloridine, cephalothin, piperacillin, cefuzonam, and aztreonam while being sensitive to cefoxitin, moxalactam, cefmetazole, ceftazidime, and imipenem, was isolated from the urine of a patient treated with beta-lactam anti
- PMID 9593147
Japanese Journal
- Synthesis and Antibacterial Activities of 2-Oxaisocephems
- 壺内 英継,辻 浩一,安村 貢一,石川 廣
- Chemical & pharmaceutical bulletin 42(10), 2084-2089, 1994-10-15
- … Among them, the derivatives having a [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopentyloxyimino]acetamido group at the 7-position characteristically showed potent activities against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis as compared with cefuzonam and cefmenoxime, which are third-generation cephalosporins. …
- NAID 110003630786
- Evaluation of minocycline and cefuzonam for antimicrobial activity against clinical isolates
Related Links
- Cefuzonam (INN) is a second-generation cephalosporin antibiotic. [edit] References. Hara K, Matsumoto F (December 1987). "[New antimicrobial agent series XXVIII: cefuzonam]" (in Japanese). Jpn J Antibiot 40 (12): 1953?63. PMID 3329242. ...
Related Pictures
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![Cephalosporin antibiotics](https://1mg.info/0/c/9/2143.jpg)
![Cefazedone is a cephalosporin antibiotic.](https://1mg.info/0/c/9/2144.jpg)
![Cefuzonam (INN) is a second-generation](https://1mg.info/0/c/9/2145.jpg)
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