WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.

He R1, Yu ZH1, Zhang RY1, Wu L1, Gunawan AM1, Zhang ZY1.
ACS medicinal chemistry letters.ACS Med Chem Lett.2015 Nov 3;6(12):1231-5. doi: 10.1021/acsmedchemlett.5b00373. eCollection 2015.
mPTPB is a virulent phosphatase from Mycobacterium tuberculosis and a promising therapeutic target for tuberculosis. To facilitate mPTPB-based drug discovery, we identified α-sulfophenylacetic amide (SPAA) from cefsulodin, a third generation β-lactam cephalosporin antibiotic, as a novel pTyr pharm
PMID 26713110

Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa.

Roemhild R1, Barbosa C1, Beardmore RE2, Jansen G1, Schulenburg H1.
Evolutionary applications.Evol Appl.2015 Dec;8(10):945-55. doi: 10.1111/eva.12330. Epub 2015 Oct 7.
Antibiotic resistance is a growing concern to public health. New treatment strategies may alleviate the situation by slowing down the evolution of resistance. Here, we evaluated sequential treatment protocols using two fully independent laboratory-controlled evolution experiments with the human path
PMID 26640520

O'Connor M1.
Molecular genetics and genomics : MGG.Mol Genet Genomics.2015 Aug;290(4):1335-44. doi: 10.1007/s00438-015-0994-x. Epub 2015 Jan 31.
The bacterial release factor RF3 is a GTPase that has been implicated in multiple, incompletely understood steps of protein synthesis. This study explores the genetic interaction of RF3 with other components of the translation machinery. RF3 contributes to translation termination by recycling the cl
PMID 25636454

田村忍,長岐為一郎,福田一郎
CHEMOTHERAPY 41(7), 750-754, 1993
… 臨床分離緑膿菌13株に対するceftazidime (CAZ), cefoperazone (CPZ), cefsulodin (CFS), latamoxef (LMOX), aztreonam (AZT) およびimipenem/cilastatin sodium (IPM) のβ-lactamase誘導能を検討した。 …
NAID 130004198096

仲村秀俊,福井俊夫,勝正孝,鳥飼勝隆,富井正邦,河合健
CHEMOTHERAPY 40(Supplement1), 312-325, 1992
新しく注射用カルバペネム系抗生物質として開発されたmeropenem (MEPM) について, 基礎的・臨床的検討を行いその有用性を検討した。 21菌種, 合計537株についてMEPMおよび対照8薬剤のMIC測定を, 日本化学療法学会法によって行った。Staphylococcus aureus はimipenem (IPM) に次いで本剤に極 …
NAID 130004197789

小原達也,松井幸雄,野田正和,大岩一彦,飯田晋也
The Japanese Journal of Antibiotics 39(5), 1372-1382, 1986
… MK-0787は図1のような構造式を持ち, グラム陽性, グラム陰性の広範囲の菌種に対し強い抗菌力を有し4, 5), 特にPseudomonas aeruginosaにCefsulodin (CFS) 及びCefbperazone (CPZ) より強い抗菌力を示し6), 従来のCephem系抗生物質が無効であつたEnterococcus faecalisに対しても強い抗菌力を示す。 …
NAID 130004394515