- 関
- cefpiramide
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/08 00:55:12」(JST)
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Cefpiramide
|
Systematic (IUPAC) name |
(6 R)-7-{[(2 R)-2-(4-hydroxyphenyl)-2-[(6-methyl-
4-oxo-1H-pyridine-3-carbonyl)amino]acetyl]amino}-
3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Intravenous, intramuscular |
Pharmacokinetic data |
Protein binding |
93% to 99.3% |
Biological half-life |
4.44 hours |
Excretion |
Renal and fecal |
Identifiers |
CAS Registry Number |
70797-11-4 Y |
ATC code |
J01DD11 |
PubChem |
CID: 636405 |
DrugBank |
DB00430 Y |
ChemSpider |
552192 Y |
UNII |
P936YA152N Y |
KEGG |
D03428 Y |
ChEBI |
CHEBI:59213 Y |
ChEMBL |
CHEMBL1201204 N |
Chemical data |
Formula |
C25H24N8O7S2 |
Molecular mass |
612.64 g/mol |
SMILES
-
O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)[C@@H](c3ccc(O)cc3)NC(=O)C\4=C\N\C(=C/C/4=O)C)CSc5nnnn5C)C(=O)O
|
InChI
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InChI=1S/C25H24N8O7S2/c1-11-7-16(35)15(8-26-11)20(36)27-17(12-3-5-14(34)6-4-12)21(37)28-18-22(38)33-19(24(39)40)13(9-41-23(18)33)10-42-25-29-30-31-32(25)2/h3-8,17-18,23,34H,9-10H2,1-2H3,(H,26,35)(H,27,36)(H,28,37)(H,39,40)/t17-,18-,23-/m1/s1 Y
-
Key:PWAUCHMQEXVFJR-PMAPCBKXSA-N Y
|
N (what is this?) (verify) |
Cefpiramide is a third-generation cephalosporin antibiotic.
External links
- Wang H, Yu Y, Xie X, Wang C, Zhang Y, Yuan Y, Zhang X, Liu J, Wang P, Chen M (2000). "In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China". J Infect Chemother 6 (2): 81–85. doi:10.1007/PL00012156. PMID 11810540.
- Iakovlev V, Vishnevskiĭ V, Khlebnikov E, Khadin I, Plavlova M, Elagina L, Izotova G (1995). "[Cefpiramide (Tamicin) in the treatment of purulent complications of abdominal surgery]". Antibiot Khimioter 40 (9): 30–4. PMID 8651827.
- Sampi K, Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective study]". Gan to Kagaku Ryoho 19 (9): 1315–20. PMID 1503486.
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(Inhibit PBP
cross-links) |
|
|
Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Gramicidin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
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|
Description |
|
|
Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
|
|
|
UpToDate Contents
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English Journal
- Antibiotic and synergistic effect of Leu-Lys rich peptide against antibiotic resistant microorganisms isolated from patients with cholelithiasis.
- Jeong N1, Kim JY, Park SC, Lee JK, Gopal R, Yoo S, Son BK, Hahm JS, Park Y, Hahm KS.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2010 Sep 3;399(4):581-6. doi: 10.1016/j.bbrc.2010.07.118. Epub 2010 Aug 2.
- Pseudomonas aeruginosa has eventually developed resistance against flomoxef sodium, isepamicin and cefpiramide. Therefore, in this study, the antibacterial activity and synergistic effects of the amphipathic-derived P5-18mer antimicrobial peptide were tested against pathogens associated with choleli
- PMID 20682287
- The efficacy of postoperative prophylactic antibiotics in orthognathic surgery: a prospective study in Le Fort I osteotomy and bilateral intraoral vertical ramus osteotomy.
- Kang SH1, Yoo JH, Yi CK.
- Yonsei medical journal.Yonsei Med J.2009 Feb 28;50(1):55-9. doi: 10.3349/ymj.2009.50.1.55. Epub 2009 Feb 24.
- PURPOSE: This study examined the efficacy of the postoperative prophylactic antibiotics used in orthognathic surgery. The prevalence of surgical site infections (SSIs) was determined according to the use of postoperative prophylactic antibiotics.PATIENTS AND METHODS: Fifty-six patients were divided
- PMID 19259349
Japanese Journal
- N-Methyltetrazolethiol基が原因と示唆されたセファロスポリン系抗生物質による薬物アレルギー性肝炎の1例
- 小島 直彦,熊本 いずみ,舛本 俊一,恩地 森一
- アレルギー 43(3), 511-514, 1994-03-30
- セファロスポリン系抗生剤による薬物アレルギー性肝炎の1例を経験し, リンパ球幼若化試験により, セファロスポリンのうちN-methyltetrazolethiol基が原因であることが示唆された症例を経験したので報告した.
- NAID 110002422465
- Electrokinetic Chromatography for Drug Analysis. Separation and Determination of Cefpiramide in Human Plasma
- 中川 照眞,小田 吉哉,澁川 明正,福田 桐子,田中 久
- Chemical & pharmaceutical bulletin 37(3), 707-711, 1989-03-25
- … Electrokinetic chromatography using a fused silica capillary and sodium dodecyl sulfate (SDS) solution has been applied to the separation and determination of cefpiramide (CPM) in human plasma with the use of antipyrine (AP) as an internal standard. …
- NAID 110003627590
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- cefpiramide、cefpiramide sodium
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