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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/11 14:31:18」(JST)

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Carnitine O-palmitoyltransferase (also called carnitine palmitoyltransferase) is a mitochondrial transferase enzyme (EC 2.3.1.21) involved in the metabolism of palmitoylcarnitine into palmitoyl-CoA. A related transferase is carnitine acyltransferase.

Molecules

Palmitoylcarnitine
Palmitoyl CoA

Pathway

Acyl-CoA from cytosol to the mitochondrial matrix

Human forms of CPT

There are four different forms of CPT in humans:

CPT1A - associated with Carnitine palmitoyltransferase I deficiency
CPT1B
CPT1C
CPT2 - associated with Carnitine palmitoyltransferase II deficiency

References

^ Jogl G, Tong L (January 2003). "Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport". Cell 112 (1): 113–22. doi:10.1016/S0092-8674(02)01228-X. PMID 12526798.

External links

PDOC00402 - Acyltransferases ChoActase / COT / CPT family in PROSITE
Choline/Carnitine o-acyltransferase family in Pfam
UMich Orientation of Proteins in Membranes protein/pdbid-2h4t
Carnitine O-Palmitoyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 腎疾患におけるカルニチン代謝と透析 carnitine metabolism in renal disease and dialysis
2. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
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4. 透析患者における赤血球造血刺激因子製剤に対する非鉄薬理学的補助 non iron pharmacologic adjuvants to erythropoiesis stimulating agent therapy in dialysis patients
5. ミトコンドリアミオパシー：治療 mitochondrial myopathies treatment

English Journal

Loss of vagal tone aggravates systemic inflammation and cardiac impairment in endotoxemic rats.

Schulte A1, Lichtenstern C2, Henrich M1, Weigand MA1, Uhle F1.
The Journal of surgical research.J Surg Res.2014 May 15;188(2):480-8. doi: 10.1016/j.jss.2014.01.022. Epub 2014 Jan 21.
BACKGROUND: During the course of sepsis, often myocardial depression with hemodynamic impairment occurs. Acetylcholine, the main transmitter of the parasympathetic Nervus vagus, has been shown to be of importance for the transmission of signals within the immune system and also for a variety of othe
PMID 24565505

The medial preoptic nucleus as a site of the thermogenic and metabolic actions of Melanotan II in male rats.

Monge-Roffarello B1, Labbé SM, Lenglos C, Caron A, Lanfray D, Samson P, Richard D.
American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2014 May 7. [Epub ahead of print]
The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the αMSH analog Melanotan II (MTII). We also assessed the involvement of the dorsomedial hypothalamic nucleus (DMH) by investigating the effects of the M
PMID 24808495

Impact of high altitude on the hepatic fatty acid oxidation and synthesis in rats.

Ni Q1, Shao Y2, Wang YZ2, Jing YH3, Zhang YC4.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Apr 4;446(2):574-9. doi: 10.1016/j.bbrc.2014.03.001. Epub 2014 Mar 12.
High altitude (HA) affects energy metabolism. The impact of acute and chronic HA acclimatization on the major metabolic pathways is still controversial. In this study, we aimed to unveil the impact of HA on the key enzymes involved in the fatty acid (FA) metabolism in liver. Rats were exposed to an
PMID 24613835

Japanese Journal

Expression of Lipid Metabolism-Associated Genes in Male and Female White Feather Chicken

The Journal of Poultry Science advpub(0), 2015
NAID 130005110992

Hyperlipidemic Guinea Pig Model: Mechanisms of Triglyceride Metabolism Disorder and Comparison to Rat

Biological and Pharmaceutical Bulletin 34(7), 1046-1051, 2011
NAID 130000738094

The role of carnitine acyltransferase in the maintenance of cell function

Monatshefte fur Chemie 136, 1299-1309, 2005
NAID 30018161026

「カルニチンアシル基転移酵素」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Choline/Carnitine o-acyltransferase
	Structure of carnitine acetyltransferase.
Identifiers
Symbol	Carn_acyltransf
Pfam	PF00755
Pfam clan	CL0149
InterPro	IPR000542
PROSITE	PDOC00402
SCOP	1ndi
SUPERFAMILY	1ndi
OPM superfamily	183
OPM protein	2h3u
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary