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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/04 13:19:24」(JST)
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Carfecillin
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Systematic (IUPAC) name |
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[ [3-oxo-3-(phenoxy)-2-phenylpropanoyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
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Identifiers |
CAS Registry Number |
27025-49-6 |
ATC code |
G01AA08 |
PubChem |
CID: 33672 |
ChemSpider |
31054 Y |
UNII |
9UU4XDB74X Y |
ChEBI |
CHEBI:3414 Y |
ChEMBL |
CHEMBL1095283 Y |
Chemical data |
Formula |
C23H22N2O6S |
Molecular mass |
454.49558 g/mol |
SMILES
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O=C(O)[C@@H]3N4C(=O)[C@@H](NC(=O)C(c1ccccc1)C(=O)Oc2ccccc2)[C@H]4SC3(C)C
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InChI
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InChI=1S/C23H22N2O6S/c1-23(2)17(21(28)29)25-19(27)16(20(25)32-23)24-18(26)15(13-9-5-3-6-10-13)22(30)31-14-11-7-4-8-12-14/h3-12,15-17,20H,1-2H3,(H,24,26)(H,28,29)/t15?,16-,17+,20-/m1/s1 Y
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Key:NZDASSHFKWDBBU-KVMCETHSSA-N Y
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Y (what is this?) (verify) |
Carfecillin is a beta-lactam antibiotic. It is a phenyl derivative of carbenicillin, acting as a prodrug.
Gynecological anti-infectives and antiseptics (G01)
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Antibiotics |
- Candicidin
- Chloramphenicol
- Hachimycin
- Oxytetracycline
- Carfecillin
- Mepartricin
- Clindamycin
- Pentamycin
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Arsenic compounds |
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Quinoline derivatives |
- Diiodohydroxyquinoline
- Clioquinol
- Chlorquinaldol
- Dequalinium
- Broxyquinoline
- Oxyquinoline
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Organic acids |
- Lactic acid
- Acetic acid
- Ascorbic acid
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Sulfonamides |
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Antifungals |
Imidazoles |
- Metronidazole
- Clotrimazole
- Miconazole
- Econazole
- Ornidazole
- Isoconazole
- Tioconazole
- Ketoconazole
- Fenticonazole
- Azanidazole
- Propenidazole
- Butoconazole
- Omoconazole
- Oxiconazole
- Flutrimazole
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Triazoles |
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Polyenes |
- Nystatin
- Natamycin
- Amphotericin B
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Other |
- Ciclopirox
- Methylrosaniline
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Other |
- Clodantoin
- Inosine
- Policresulen
- Nifuratel
- Furazolidone
- Povidone-iodine
- Protiofate
- Lactobacillus fermentum
- Copper usnate
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Index of reproductive medicine
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Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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English Journal
- Val-237 for Ala substitution in the TEM-2 beta-lactamase dramatically alters the catalytic efficiencies towards carbenicillin and ticarcillin.
- Barthélémy M, Péduzzi J, Rowlands D, Paul G, Moreau G, Labia R.SourceMuséum National Histoire Naturelle, CNRS URA 401, Paris, France.
- FEMS microbiology letters.FEMS Microbiol Lett.1994 Apr 15;117(3):333-9.
- The mutant 554 of TEM-2 beta-lactamase was selected for a decrease in the resistance to carbenicillin of an Escherichia coli K12 carrier. The amino acid sequence of the mutant beta-lactamase was determined by manual Edman degradation analysis of proteolytic peptides. A single substitution Val for Al
- PMID 8200509
- Novel inhibitors of enkephalin-degrading enzymes. IV: Structure-activity relationships within the penicillins as enkephalinase inhibitors.
- Livingston SJ, Smith HJ, Sewell RD, Ahmed S.SourceWelsh School of Pharmacy, U.W.C.C., Cardiff, UK.
- Journal of enzyme inhibition.J Enzyme Inhib.1992;6(2):165-73.
- A range of penicillins have been examined as competitive reversible inhibitors of enkephalinase (neutral endopeptidase; EC 3.4.24.11). Carfecillin (Ki = 0.18 microM) was the most potent inhibitor in the series, whereas cloxacillin (27.5 microM), ampicillin (41.0 microM), nafcillin (58.7 microM) and
- PMID 1284433
- Pharmacologic enhancement or suppression of phagocytosis by bovine neutrophils.
- Paape MJ, Miller RH, Ziv G.SourceMilk Secretion and Mastitis Laboratory, USDA-Agricultural Research Service, Beltsville, MD 20705.
- American journal of veterinary research.Am J Vet Res.1991 Feb;52(2):363-6.
- Sixty-three drugs, belonging to 10 chemical classes, were tested in vitro to determine effects on phagocytosis of 32P-labeled Staphylococcus aureus by neutrophils isolated from milk. Within each class, the number of antibiotics tested were: nonsteroidal anti-inflammatory drugs (NSAID; 8), peptolids
- PMID 2012350
Japanese Journal
- Carfecillin(BRL-3475)の臨床的経験 : 第41回山陰地方会
- 産婦人科領域における尿路感染症に対するCarfecillin(phenyl CBPC)の効果について
- 尿路感染症に対するCarfecillin sodium(Uticillin錠)の使用経験
Related Links
- Carfecillin information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Search Specialists by State and City
- polyene antimycotic (Nystatin, Natamycin, Amphotericin B) - Candicidin - Chloramphenicol - Hachimycin - Oxytetracycline - Carfecillin - Mepartricin - Clindamycin - Pentamycin Arsenic compounds Acetarsol Quinoline derivatives ...
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