心保護、心臓保護

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1. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning
2. 心臓の虚血性再潅流障害 ischemic reperfusion injury of the heart
3. 適度なアルコール摂取の心血管に対する利益とリスク cardiovascular benefits and risks of moderate alcohol consumption
4. 拡張型心筋症の原因 causes of dilated cardiomyopathy
5. 慢性関節リウマチにおける心不全および左室機能不全 heart failure and left ventricular dysfunction in rheumatoid arthritis

English Journal

Transcutaneous electrical nerve stimulation as a novel method of remote preconditioning: in vitro validation in an animal model and first human observations.

Merlocco AC1, Redington KL, Disenhouse T, Strantzas SC, Gladstone R, Wei C, Tropak MB, Manlhiot C, Li J, Redington AN.Author information 1The Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G1X8, Canada.AbstractRemote ischemic preconditioning (rIPC) induced by transient limb ischemia (li-rIPC) leads to neurally dependent release of blood-borne factors that provide potent cardioprotection. We hypothesized that transcutaneous electrical nerve stimulation (TENS) is a clinically relevant stimulus of rIPC. Study 1: seven rabbits were subjected to lower limb TENS; six to li-rIPC, and six to sham intervention. Blood was drawn and used to prepare a dialysate for subsequent analysis of cardioprotection in rabbit Langendorff preparation. Study 2: 14 healthy adults underwent upper limb TENS stimulation on one study day, 10 of whom also underwent li-rIPC on another study day. Blood was drawn before and after each stimulus, dialysate prepared, and cardioprotective activity assessed in mouse Langendorff preparation. The infarct size and myocardial recovery were measured after 30 min of global ischemia and 60 or 120 min of reperfusion. Animal validation: compared to control, TENS induced marked cardioprotection with significantly reduced infarct size (TENS vs. sham p < 0.01, rIPC vs. sham p < 0.01, TENS vs. rIPC p = ns) and improved functional recovery during reperfusion. Human study: compared to baseline, dialysate after rIPC (pre-rIPC vs. post-rIPC, p < 0.001) and TENS provided potent cardioprotection (pre-TENS vs. post-TENS p < 0.001) and improved myocardial recovery during reperfusion. The cardioprotective effects of TENS dialysates were blocked by pretreatment of the receptor heart with the opioid antagonist naloxone. TENS is a novel method for inducing cardioprotection and may provide an alternative to the limb ischemia stimulus for induction of rIPC clinically.
Basic research in cardiology.Basic Res Cardiol.2014 May;109(3):406. doi: 10.1007/s00395-014-0406-0. Epub 2014 Mar 7.
Remote ischemic preconditioning (rIPC) induced by transient limb ischemia (li-rIPC) leads to neurally dependent release of blood-borne factors that provide potent cardioprotection. We hypothesized that transcutaneous electrical nerve stimulation (TENS) is a clinically relevant stimulus of rIPC. Stud
PMID 24604614

Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation.

Kottenberg E1, Thielmann M, Kleinbongard P, Frey UH, Heine T, Jakob H, Heusch G, Peters J.Author information 1Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Essen, Germany.AbstractBACKGROUND: Remote ischaemic pre-conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre-conditioning, we assessed whether remote ischaemic pre-conditioning effects are altered in sulphonylurea-treated diabetics.
Acta anaesthesiologica Scandinavica.Acta Anaesthesiol Scand.2014 Apr;58(4):453-62. doi: 10.1111/aas.12278. Epub 2014 Feb 18.
BACKGROUND: Remote ischaemic pre-conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre-conditioning, we assessed whether remote ischaemic pre-conditioning effects are altered in sulphonylurea-treated diabetics.METHODS: Using the database
PMID 24548338

Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.

Stenkula KG1, Lindahl M, Petrlova J, Dalla-Riva J, Göransson O, Cushman SW, Krupinska E, Jones HA, Lagerstedt JO.Author information 1Department of Experimental Medical Science, Lund University, S-221 84, Lund, Sweden.AbstractAIMS/HYPOTHESIS: Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).
Diabetologia.Diabetologia.2014 Apr;57(4):797-800. doi: 10.1007/s00125-014-3162-7. Epub 2014 Jan 18.
AIMS/HYPOTHESIS: Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in
PMID 24442447

Japanese Journal

Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine

Shibata Itsuko,Cho Sungsam,Yoshitomi Osamu,Ureshino Hiroyuki,Maekawa Takuji,Hara Tetsuya,Sumikawa Koji
Scandinavian Cardiovascular Journal 47(1), 50-57, 2013-02-00
… Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. …
NAID 120005230617

Protective Effects and Active Ingredients of Yi-Qi-Fu-Mai Sterile Powder Against Myocardial Oxidative Damage in Mice

Wang Yu-Qing,Liu Chun-Hua,Zhang Jie-Qiong,Zhu Dan-Ni,Yu Bo-Yang
Journal of Pharmacological Sciences 122(1), 17-27, 2013
This study aims to evaluate the protective effects of Yi-Qi-Fu-Mai sterile powder (YQFM) on myocardial oxidative damage and tries to identify the active components responsible for its pharmacological …
NAID 130003362696

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

Bhuiyan Md. Shenuarin,Tagashira Hideaki,Fukunaga Kohji
Journal of Pharmacological Sciences 121(3), 177-184, 2013
… We recently found very high expression of the sigma-1 receptor, an orphan receptor, in rat heart tissue and defined the cardiac sigma-1 receptor as a direct SSRI target in eliciting cardioprotection in both pressure overload (PO)induced and transverse aortic constriction (TAC)-induced myocardial hypertrophy models in rodents. …
NAID 130003362688