Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels.
Kumfu S, Chattipakorn S, Fucharoen S, Chattipakorn N.SourceCardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University , Chiang Mai , Thailand.
Drug and chemical toxicology.Drug Chem Toxicol.2013 Jul;36(3):329-34. doi: 10.3109/01480545.2012.726625. Epub 2012 Oct 11.
Iron-overload cardiomyopathy is a major cause of death in thalassemic patients. However, pathways of non-transferrin-bound iron (NTBI) uptake into cardiomyocytes under iron-overload conditions are still controversial. We previously demonstrated that Fe(2+) uptake in thalassemic cardiomyocytes is mai
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor.
Thomas CM, Yong QC, Seqqat R, Chandel N, Feldman DL, Baker KM, Kumar R.Source*Division of Molecular Cardiology, Department of Medicine, Texas A&M Health Science Center, College of Medicine; Scott and White; Central Texas Veterans Health Care System, Temple, TX 76504, U.S.A.
Hyperglycaemia up-regulates intracellular AngII (angiotensin II) production in cardiac myocytes, effects of which are blocked more effectively by renin inhibition than ARBs (angiotensin receptor blockers) or ACEis (angiotensin-converting enzyme inhibitors). In the present study, we determined whethe
The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provide
A-type (atrial) natriuretic peptide (ANP) levels in heart and plasma were examined by immunohistochemistry, electron microscopy, and radioimmunoassay (RIA) in hypertensive transgenic mice (Tsukuba hyp …