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English Journal

The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells.

Jeon JY1, Lee H2, Park J2, Lee M1, Park SW1, Kim JS1, Lee M1, Cho B3, Kim K4, Choi AM5, Kim CK6, Yun M7.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jul 31;463(3):440-6. doi: 10.1016/j.bbrc.2015.05.103. Epub 2015 May 30.
The glycolytic phenotype is a dominant metabolic phenomenon in cancer and is reflected in becoming aggressive. Certain hepatocellular carcinoma lack increased glycolysis and prefer to uptake acetate than glucose for metabolism. Autophagy plays a role in preserving energies and nutrients when there i
PMID 26036577

PCBP2 regulates hepatic insulin sensitivity via HIF-1α and STAT3 pathway in HepG2 cells.

Xia N1, Tang Z2, Wang C1, Xu G3, Nie X3, Zhang W1, Zhao Y1, Wang S1, Zhu X4, Cui S5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jul 17;463(1-2):116-22. doi: 10.1016/j.bbrc.2015.04.150. Epub 2015 May 19.
Elevated free fatty acids (FFAs) are fundamental to the pathogenesis of hepatic insulin resistance. However, the molecular mechanisms of insulin resistance remain not completely understood. Transcriptional dysregulation, post-transcriptional modifications and protein degradation contribute to the pa
PMID 26002461

Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae.

Wang H1, Semenova S1, Kuusela S1, Panula P1, Lehtonen S2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2015 Jul 13. pii: fj.15-271817. [Epub ahead of print]
The central melanocortin system is a key regulator of energy homeostasis. Recent studies indicate that tankyrases (TNKSs), which poly(ADP-ribosyl)ate target proteins and direct them toward proteasomal degradation, affect overall metabolism, but the exact molecular mechanisms remain unclear. We used
PMID 26169937

Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice

An Active Part of Artemisia sacrorum Ledeb. Suppresses Gluconeogenesis through AMPK Mediated GSK3β and CREB Phosphorylation in Human HepG2 Cells

YUAN Hai-Dan,PIAO Guang-Chun
Bioscience, biotechnology, and biochemistry 75(6), 1079-1084, 2011-06-23
… PEASL downregulated the gluconeogenesis gene expression of peroxisome proliferation activated receptor-γ coactivator-1α (PGC-1α), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) in a concentration-dependent manner. …
NAID 10029327928

拡張検索	「GTP-dependent phosphoenolpyruvate carboxykinase」「ATP-dependent phosphoenolpyruvate carboxykinase」「phosphoenolpyruvate carboxykinase」