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English Journal

Squarate-based carbocyclic nucleosides: Syntheses, computational analyses and anticancer/antiviral evaluation.

Lu M1, Lu QB2, Honek JF3.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2017 Jan 15;27(2):282-287. doi: 10.1016/j.bmcl.2016.11.058. Epub 2016 Nov 23.
Squaric acid and its derivatives are versatile synthons and have demonstrated applications in medicinal chemistry, notably as non-classical bioisosteric replacements for functional groups such as carboxylic acids, alpha-amino acids, urea, guanidine, peptide bonds and phosphate/pyrophosphate linkages
PMID 27913181

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

Hercík K1, Kozak J1, Šála M1, Dejmek M1, Hřebabecký H1, Zborníková E1, Smola M1, Ruzek D2, Nencka R3, Boura E4.
Antiviral research.Antiviral Res.2017 Jan;137:131-133. doi: 10.1016/j.antiviral.2016.11.020. Epub 2016 Nov 27.
We describe the expression and purification of an active recombinant Zika virus RNA-dependent RNA polymerase (RdRp). Next, we present the development and optimization of an in vitro assay to measure its activity. We then applied the assay to selected triphosphate analogs and discovered that 2'-C-me
PMID 27902932
PMID 27815125