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The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents.

Leung YM1, Tzeng JI, Kuo CS, Chen YW, Chu CC, Wang JJ.
European journal of pharmacology.Eur J Pharmacol.2013 Aug 15;714(1-3):366-72. doi: 10.1016/j.ejphar.2013.07.013. Epub 2013 Jul 16.
Although carbetapentane produces skin (peripheral) infiltrative analgesia, the underlying mechanism of carbetapentane in local anesthesia is not well understood. The purpose of the study was to examine the effect of carbetapentane on voltage-gated Na(+) channels and its efficacy on spinal (central)
PMID 23872380

Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons.

White SH1, Brisson CD, Andrew RD.
Journal of neurophysiology.J Neurophysiol.2012 Apr;107(8):2083-95. doi: 10.1152/jn.00701.2011. Epub 2012 Jan 25.
As an immediate consequence of stroke onset, failure of the Na(+)-K(+)-ATPase pump evokes a propagating anoxic depolarization (AD) across gray matter. Acute neuronal swelling and dendritic beading arise within seconds in the future ischemic core, imaged as changes in light transmittance (ΔLT). AD i
PMID 22279188

Characterization of pentoxyverine metabolites in urine using GC/MS after intoxication with Silomat cough drops.

Westphal F1, Junge T, Radünz L, Stegk J, Rochholz G.
Forensic science international.Forensic Sci Int.2012 Feb 10;215(1-3):124-35. doi: 10.1016/j.forsciint.2011.03.002. Epub 2011 Mar 30.
A nearly two and a half year old boy was hospitalized after showing symptoms of disorientation and hallucination. The parents remembered the child playing with a bottle of Silomat cough drops, so that an intoxication was taken into consideration. After liquid/liquid extraction of a urine sample coll
PMID 21450423