carbadox

カルバドクス、カルバドックス

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/19 17:32:33」(JST)

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Carbadox
IUPAC name methyl (2E)-2-[(1,4-dioxidoquinoxalin-2-yl) methylene]hydrazinecarboxylate
Identifiers
CAS number	6804-07-5 N
PubChem	5353472
ChemSpider	10606106 Y
EC number	229-879-0
ChEMBL	CHEMBL13779 Y
RTECS number	FE2779000
Jmol-3D images	Image 1
SMILES COC(=O)N\N=C\c2c[n+]([O-])c1ccccc1[n+]2[O-]
InChI InChI=1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+ Y Key: OVGGLBAWFMIPPY-WUXMJOGZSA-N Y InChI=1/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+ Key: OVGGLBAWFMIPPY-WUXMJOGZBN
Properties
Molecular formula	C11H10N4O4
Molar mass	262.22 g/mol
Appearance	Yellow crystals
Density	1.44 g/cm3
Melting point	239.5 °C
Solubility in water	Insoluble
Hazards
EU classification	F, T
R/S statement	R: R45, R11, R22 S: S53, S45
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carbadox is a drug that combats bacterial infection in swine, particularly swine dysentery. In early 2004 it was banned by the Canadian government as a livestock feed additive and for human consumption. The European Union also forbids the use of Carbadox at any level.^{[citation needed]} It is approved in the United States for use in swine for up to 42 days before slaughter.^{[citation needed]} Australia also forbids the use of Carbadox for Food Producing Animals.

References

English Journal

• Dual-label quantum dot-based immunoassay for simultaneous determination of Carbadox and Olaquindox metabolites in animal tissues.

• Le T1, Zhu L2, Yu H3.
• Food chemistry.Food Chem.2016 May 15;199:70-4. doi: 10.1016/j.foodchem.2015.11.116. Epub 2015 Nov 26.
• A novel and reliable dual-label direct competitive fluorescence-linked immunosorbent assay (dc-FLISA) based on quantum dots (QDs) was developed for the simultaneous determination of the major metabolites of Carbadox and Olaquindox residues in animal tissues, using anti-QCA monoclonal antibodies and
• PMID 26775945

• Simultaneous determination of five quinoxaline-1,4-dioxides in animal feeds using an immunochromatographic strip.

• Le T1, Zhu L2, Shu L1, Zhang L1.
• Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2016 Feb;33(2):244-51. doi: 10.1080/19440049.2015.1124461. Epub 2015 Dec 23.
• An immunochromatographic (ICG) strip was developed for the simultaneous quantitative determination of five quinoxaline-1,4-dioxides in animal feed. For this purpose, polyclonal antibodies (PcAb) with group-specific quinoxaline-1,4-dioxides were conjugated to colloidal gold particles as the detection
• PMID 26666867

• In vivo studies to highlight possible illegal treatments of rabbits with carbadox and olaquindox.

• Segato G1, Biancotto G1, Agnoletti F2, Berto G2, Montesissa C3, Benetti C1.
• Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2015 Dec;32(12):1976-91. doi: 10.1080/19440049.2015.1086822. Epub 2015 Oct 21.
• For the treatment of rabbit dysentery and bacterial enteritis, veterinary practitioners often adopt veterinary medicinal products authorised for other food-producing species, but in some cases non-authorised drugs frequently used in the past, such as carbadox and olaquindox, might be illegally adopt
• PMID 26400201

Japanese Journal

• Drug-susceptibility of isolates of Brachyspira hyodysenteriae isolated from colonic mucosal specimens of pigs collected from slaughter houses in Japan in 2009

• Journal of Veterinary Medical Science 78(3), 517-519, 2016
• NAID 130005140884

• Drug-susceptibility of isolates of <i>Brachyspira hyodysenteriae</i> isolated from colonic mucosal specimens of pigs collected from slaughter houses in Japan in 2009

• Journal of Veterinary Medical Science advpub(0), 2015
• NAID 130005109967

• Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogens in rats

• The Journal of Toxicological Sciences 40(6), 855-871, 2015
• NAID 130005108874

Related Links

• carbadox - definition of carbadox by Medical dictionary

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• Carbadox, Carbadox Suppliers and Manufacturers at Alibaba.com

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