caramiphen

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/07 04:32:33」(JST)

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Caramiphen

Clinical data
Trade names	Carafen
ATC code	None
Identifiers
IUPAC name 2-(Diethylamino)ethyl 1-phenylcyclopentanecarboxylate
CAS Number	77-22-5
PubChem (CID)	6472
ChemSpider	6228
ChEMBL	CHEMBL61946
ECHA InfoCard	100.000.922
Chemical and physical data
Formula	C18H27NO2
Molar mass	289.413 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCCN(CC)CC)C2(c1ccccc1)CCCC2
InChI InChI=1S/C18H27NO2/c1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16/h5-7,10-11H,3-4,8-9,12-15H2,1-2H3 Key:OFAIGZWCDGNZGT-UHFFFAOYSA-N

Caramiphen is an anticholinergic drug used in the treatment of Parkinson's disease. In combination with phenylpropanolamine it is used as a cough suppressant and nasal decongestant to treat symptoms associated with respiratory illnesses such as cold, allergies, hay fever, and sinusitis.

See also

• Metcaraphen

References

English Journal

• Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats.

• Schultz MK1, Wright LK1, de Araujo Furtado M2, Stone MF1, Moffett MC1, Kelley NR1, Bourne AR1, Lumeh WZ1, Schultz CR1, Schwartz JE1, Lumley LA3.
• Neurotoxicology and teratology.Neurotoxicol Teratol.2014 Jul-Aug;44:89-104. doi: 10.1016/j.ntt.2014.06.002. Epub 2014 Jun 16.
• The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate
• PMID 24946037

• Magnesium sulfate treatment against sarin poisoning: dissociation between overt convulsions and recorded cortical seizure activity.

• Katalan S1, Lazar S, Brandeis R, Rabinovitz I, Egoz I, Grauer E, Bloch-Shilderman E, Raveh L.
• Archives of toxicology.Arch Toxicol.2013 Feb;87(2):347-60. doi: 10.1007/s00204-012-0916-1. Epub 2012 Sep 28.
• Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain anticonvulsants to block seizure activity and the ensuing brain damage. Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant wome
• PMID 23052190

Japanese Journal

• Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test

• Neuroscience Letters 481(3), 188-190, 2010-09
• NAID 120003020800

• ＧＩＲＫチャネル阻害作用を持つ薬物の新規抗うつ様作用

• 薬学雑誌. 乙号 130(5), 699-705, 2010
• NAID 130000259458

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