出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/12 21:07:57」(JST)
Systematic (IUPAC) name | |
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10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
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Clinical data | |
Trade names | Contaren, Luvion, Phanurane, Spiroletan |
AHFS/Drugs.com | International Drug Names |
Pharmacokinetic data | |
Protein binding | 95% |
Biological half-life | 10–35 hours |
Identifiers | |
CAS Number | 976-71-6 N |
ATC code | C03DA03 (WHO) |
PubChem | CID 13789 |
ChemSpider | 13192 Y |
UNII | 78O20X9J0U Y |
ChEMBL | CHEMBL1463345 N |
Synonyms | RP-11614, SC-9376 |
Chemical data | |
Formula | C22H28O3 |
Molar mass | 340.456 g/mol |
3D model (Jmol) | Interactive image |
SMILES
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InChI
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Canrenone (INN, USAN) (brand names Contaren, Luvion, Phanurane, Spiroletan), also known as aldadiene,[1] is a steroidal antimineralocorticoid and weak antiandrogen and progestogen[2][3] of the spirolactone group related to spironolactone which is or has been used as a diuretic in Europe, including in Italy and Belgium.[4][5][6]
Canrenone is an active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is believed to be partially or largely responsible for their effects (depending on the drug in question).[7]
Canrenone is more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and effective as an antiandrogen.[8][9] Similarly to spironolactone, canrenone inhibits steroidogenic enzymes such as 11β-hydroxylase, cholesterol side-chain cleavage enzyme, 17α-hydroxylase, and 21-hydroxylase, but once again, is comparatively less potent in doing so.[10]
Canrenone has been found to be effective in the treatment of hirsutism in women.[11]
Antihypertensives: diuretics (C03)
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Sulfonamides (and etacrynic acid) |
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Potassium-sparing (at CD) |
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Osmotic diuretics (PT, DL) |
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Vasopressin receptor inhibitors (DCT and CD) |
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Other |
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Mineralocorticoids and antimineralocorticoids (H02)
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Mineralocorticoids |
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Antimineralocorticoids |
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Synthesis modifiers |
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Androgens and antiandrogens
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Androgens (incl. AAS) |
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Antiandrogens |
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Androgen receptor modulators
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AR |
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GPRC6A |
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See also: Estrogenics • Glucocorticoidics • Mineralocorticoidics • Progestogenics • Steroid hormone metabolism modulators
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Mineralocorticoid receptor modulators
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MR |
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See also: Androgenics • Estrogenics • Glucocorticoidics • Progestogenics • Steroid hormone metabolism modulators
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Progesterone receptor modulators
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PR |
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mPRs (PAQRs) |
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See also: Androgenics • Estrogenics • Glucocorticoidics • Mineralocorticoidics • Steroid hormone metabolism modulators
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Steroid hormone metabolism modulators
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HMGCR |
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FPS |
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24-DHCR24 |
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20,22-Desmolase (P450scc) |
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17α-Hydroxylase, 17,20-Lyase |
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3α-HSD |
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3β-HSD |
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11β-HSD |
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21-Hydroxylase |
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11β-Hydroxylase |
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18-Hydroxylase |
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17β-HSD |
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5α-Reductase |
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Aromatase |
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SST/EST |
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STS |
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27-Hydroxylase |
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Others |
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See also: Androgenics • Estrogenics • Glucocorticoidics • Mineralocorticoidics • Progestogenics
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