calcimimetic

• adj.

• カルシウム模倣の

• n.

• カルシウム擬態薬

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/24 11:18:47」(JST)

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A calcimimetic is a drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Calcimimetics are used to treat hyperparathyroidism.

Cinacalcet is a calcimimetic. Cinacalcet (brand name Sensipar) is the only drug of this class. Cinacalcet mimics calcium at the parathyroid hormone receptor. This binding will increase the sensitivity of calcium-sensing receptors on the parathyroid gland. As a result of the receptor "thinking" there is sufficient calcium, PTH secretion will be reduced. Lower calcium levels will be seen as well.

Calcimimetics can be used concomitantly with vitamin D therapy.

Calcimimetic use can have side effects. Common side effects include: Nausea and vomiting, hypocalcemia, and adynamic bone disease if iPTH levels drop below 100pg/mL.

References

UpToDate Contents

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• 1. 慢性腎疾患を有する透析前の成人患者における二次性副甲状腺機能亢進症およびミネラル代謝異常のマネージメント management of secondary hyperparathyroidism and mineral metabolism abnormalities in adult predialysis patients with chronic kidney disease
• 2. 透析患者における二次性副甲状腺機能亢進症およびミネラル代謝異常のマネージメント management of secondary hyperparathyroidism and mineral metabolism abnormalities in dialysis patients
• 3. 高カルシウム血症の治療 treatment of hypercalcemia
• 4. カルシウム感知性受容体障害：家族性低カルシウム尿性高カルシウム血症および常染色体優性低カルシウム血症 disorders of the calcium sensing receptor familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
• 5. Primary hyperparathyroidism: Management

English Journal

• Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis.

• Wu CL1, Wu QY1, Du JJ1, Zeng JY1, Li TT2, Xu CQ3, Sun YH4.
• Molecular immunology.Mol Immunol.2015 Feb;63(2):337-42. doi: 10.1016/j.molimm.2014.08.007. Epub 2014 Sep 23.
• Calcium-sensing receptor (CaSR) is a member of the G protein-coupled receptor superfamily that existed in lymphocytes and promoted cytokine secretion. Lymphocytes are also involved in sepsis. However, the role of CaSR in lymphocytes in sepsis is unclear. In this study, we want to examine whether the
• PMID 25256599

• Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization.

• Brennan SC1, Mun HC, Leach K, Kuchel PW, Christopoulos A, Conigrave AD.
• Endocrinology.Endocrinology.2015 Jan 21:en20141771. [Epub ahead of print]
• Calcium-sensing receptors (CaSRs) are class C G-protein-coupled receptors (GPCRs) that respond to physiological activators, including extracellular Ca2+ (Ca2+o) and L-amino acids, as well as the pharmaceutical calcimimetic, cinacalcet. Unlike Ca2+o, which is an orthosteric agonist, L-amino acids and
• PMID 25607893

• Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells.

• Hernández-Bedolla MA1, Carretero-Ortega J2, Valadez-Sánchez M1, Vázquez-Prado J3, Reyes-Cruz G4.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jan;1853(1):166-82. doi: 10.1016/j.bbamcr.2014.10.011. Epub 2014 Oct 22.
• Breast cancer metastasis to the bone, potentially facilitated by chemotactic and angiogenic cytokines, contributes to a dramatic osteolytic effect associated with this invasive behavior. Based on the intrinsic ability of calcium sensing receptor (CaSR) to control hormonal secretion and considering i
• PMID 25409930

Japanese Journal

• Calcium Overload Accelerates Phosphate-Induced Vascular Calcification Via Pit-1, but not the Calcium-Sensing Receptor

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ, 2016
• NAID 130005277948

• 3. 副甲状腺の外科(<特集>内分泌外科の現状と将来)

• 日本外科学会雑誌 113(6), 490-495, 2012-11-01
• NAID 110009554101

• 残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg, K代謝に及ぼす影響

• 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 44(10), 1007-1013, 2011-10-28
• NAID 10029861706

Related Links

• Calcimimetic, AMG 073, induces relaxation on isolated rat aorta

Calcimimetics are a class of compounds that positively modulate the calcium-sensing receptor (CaR) by allosterically increasing the affinity of the receptor for ... 3.2. Effect of AMG 073 on Phenylephrine-precontracted aortic rings ...

• Calcimimetic agents and secondary hyperparathyroidism ...

Summary Calcimimetic agents represent a novel therapeutic approach to secondary hyperparathyroidism. They directly target the molecular mechanism that regulates PTH secretion from the parathyroid glands. In ...

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リンク元	「カルシウム模倣」「カルシウム擬態薬」

「カルシウム模倣」

　　[★]

英

calcimimetic

関

カルシウム擬態薬

「カルシウム擬態薬」

　　[★]

英

calcimimetic

関

カルシウム模倣