butyrate response factor 1

酪酸反応因子1

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. a result; "this situation developed in response to events in Africa"
12. a phrase recited or sung by the congregation following a versicle by the priest or minister
13. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/17 03:17:23」(JST)

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[Wiki en表示]

ZFP36 ring finger protein-like 1
PDB rendering based on 1rgo.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1W0V, 1W0W
Identifiers
Symbols	ZFP36L1 ; BRF1; Berg36; ERF-1; ERF1; RNF162B; TIS11B; cMG1
External IDs	OMIM: 601064 MGI: 107946 HomoloGene: 31276 GeneCards: ZFP36L1 Gene
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • mRNA binding • protein binding • AU-rich element binding • poly(A) RNA binding • metal ion binding Cellular component • nucleus • cytosol Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • vasculogenesis • proepicardium development • regulation of transcription, DNA-templated • regulation of translation • apoptotic process • heart development • cell proliferation • gene expression • neural tube development • T cell differentiation in thymus • multicellular organism growth • regulation of mRNA stability • chorio-allantoic fusion • spongiotrophoblast layer development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	677	12192
Ensembl	ENSG00000185650	ENSMUSG00000021127
UniProt	Q07352	P23950
RefSeq (mRNA)	NM_001244698	NM_007564
RefSeq (protein)	NP_001231627	NP_031590
Location (UCSC)	Chr 14: 68.79 – 68.8 Mb	Chr 12: 80.11 – 80.11 Mb
PubMed search	[1]	[2]

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.

Function

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.

Interactions

ZFP36L1 has been shown to interact with MAPK14.

References

Further reading

• Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M (August 2010). "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia". Nat. Immunol. 11 (8): 717–24. doi:10.1038/ni.1901. PMC 2953641. PMID 20622884. 
• Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, Burton GJ, Murphy JJ, Norton JD, Clark AR, Turner M (November 2006). "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression". Dev. Dyn. 235 (11): 3144–55. doi:10.1002/dvdy.20949. PMID 17013884. 
• Barnard RC, Pascall JC, Brown KD, McKay IA, Williams NS, Bustin SA (July 1993). "Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes". Nucleic Acids Res. 21 (15): 3580. doi:10.1093/nar/21.15.3580. PMC 331466. PMID 8346037. 
• Maclean KN, See CG, McKay IA, Bustin SA (November 1995). "The human immediate early gene BRF1 maps to chromosome 14q22-q24". Genomics 30 (1): 89–90. doi:10.1006/geno.1995.0014. PMID 8595910. 
• Ning ZQ, Norton JD, Li J, Murphy JJ (October 1996). "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36". Eur. J. Immunol. 26 (10): 2356–63. doi:10.1002/eji.1830261013. PMID 8898945. 
• Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H (2003). "Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins". Prog. Nucleic Acid Res. Mol. Biol. 75: 43–68. doi:10.1016/S0079-6603(03)75002-8. PMID 14604009. 
• Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R (November 2004). "Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells". Biochem. Biophys. Res. Commun. 324 (1): 218–23. doi:10.1016/j.bbrc.2004.09.030. PMID 15465005. 
• Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, Lamarre J, Feige JJ (November 2004). "Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b". Oncogene 23 (53): 8673–80. doi:10.1038/sj.onc.1207939. PMID 15467755. 

UpToDate Contents

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English Journal

• The roles of TTP and BRF proteins in regulated mRNA decay.

• Sanduja S, Blanco FF, Dixon DA.SourceDepartment of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC, USA.
• Wiley interdisciplinary reviews. RNA.Wiley Interdiscip Rev RNA.2011 Jan-Feb;2(1):42-57. doi: 10.1002/wrna.28.
• Adenylate- and uridylate-rich element (ARE) motifs are cis-acting elements present in the 3′ untranslated region of mRNA transcripts that encode many inflammation- and cancer-associated genes. The TIS11 family of RNA-binding proteins, composed of tristetraprolin (TTP) and butyrate response factors
• PMID 21278925

• A novel concept in antiangiogenic and antitumoral therapy: multitarget destabilization of short-lived mRNAs by the zinc finger protein ZFP36L1.

• Planel S, Salomon A, Jalinot P, Feige JJ, Cherradi N.SourceInstitut National de la Santé et de la Recherche Médicale, Grenoble, Rhône-Alpes, France.
• Oncogene.Oncogene.2010 Nov 11;29(45):5989-6003. doi: 10.1038/onc.2010.341. Epub 2010 Aug 30.
• Angiogenesis inhibitors have shown clinical benefits in patients with advanced cancer, but further therapeutic improvement is needed. We have previously shown that the zinc finger protein 36, C3H type-like 1 (ZFP36L1) enhances vascular endothelial growth factor (VEGF) mRNA decay through its interact
• PMID 20802528

• ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

• Vignudelli T, Selmi T, Martello A, Parenti S, Grande A, Gemelli C, Zanocco-Marani T, Ferrari S.SourceUniversità di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, 41100, Modena, Italy.
• Molecular biology of the cell.Mol Biol Cell.2010 Oct 1;21(19):3340-51. doi: 10.1091/mbc.E10-01-0040. Epub 2010 Aug 11.
• ZFP36L1 is a member of a family of CCCH tandem zinc finger proteins (TTP family) able to bind to AU-rich elements in the 3'-untranslated region of mRNAs, thereby triggering their degradation. The present study suggests that such mechanism is used during hematopoiesis to regulate differentiation by p
• PMID 20702587

Japanese Journal

• Butyric acid stimulates bone sialoprotein gene transcription

• Yang Li,Li Zhengyang,Li Xinyue,Wang Zhitao,Wang Shuang,Sasaki Yoko,Takai Hideki,Ogata Yorimasa
• Journal of Oral Science 52(2), 231-237, 2010
• … Butyric acid (sodium butyrate; … Transcriptional stimulation by BA was abrogated in the pLUC3 construct which containing a 2-bp mutation in the fibroblast growth factor 2 response element (FRE). …
• NAID 130000301259

• 低用量のAraC,VP-16とG-CSFの併用療法中に著名な皮膚浸潤を呈した急性骨髄性白血病(M5a)

• 河内 康憲,桑島 靖子,西原 利男,内田 立身,瀬津 弘順,森 将晏,池田 和眞,池田 宇次,佐々木 一乗,高原 二郎
• 臨床血液 38(9), 763-769, 1998-09-30
• … 芽球はMPO陰性，CD11a, b, c, CD33陽性，α-naphthyl butyrate esterase陽性で，t(9;11)(p22;q23)とこれを含む-7と+19の3種類の核型異常を認めた。 …
• NAID 10005233901

• Inhibition of GH Releasing Factor (GRF)-lnduced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep.

• MATSUNAGA NOBUYOSHI,GOKA TAISEI,NAM KI TAEG,ODA SHINICHI,OHNEDA AKIRA,SASAKI YASUYUKI
• Endocrine Journal 44(1), 133-140, 1997
• … A VFA mixture solution containing acetate, propionate and butyrate (the molar ratio of acetate, propionate and n-butyrate =61.7:24.3:14.0) was infused into the rumen at various rates (53.5, 107 and 214μmol kg-1 min-1) over 6h to examine the effects on basal and growth hormone-releasing factor (GRF, 0.25μg kg-1)-induced increase in secretion of GH, insulin, glucagon and somatostatin (SRIF) in five castrated male sheep. …
• NAID 130003549716

Related Links

• Butyrate Response Factor 1 | Profiles RNS

"Butyrate Response Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... A ZINC FINGER MOTIF containing immediate early protein that is closely ...

• 【類似比較できる横断的カタログ】butyrate response factor 1 ...

仕様 ※ 以下はバイオの買物.comがメーカーウェブサイトから自動抽出したスペックです。 Product Name : butyrate response factor 1 (phospho S92) antibody Product type : Primary antibodies Description : Rabbit polyclonal to ...

Related Pictures

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★リンクテーブル★

リンク元	「酪酸反応因子1」
関連記事	「fact」「factor」「response」「butyrate」

「酪酸反応因子1」

　　[★]

英

butyrate response factor 1

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応

　 　 　 　

「butyrate」

　　[★]

酪酸、酪酸エステル、酪酸塩

関

butanoic acid、butyric acid

• butyric acid