English Journal

Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.

Zwick V1, Nurisso A1, Simões-Pires C1, Bouchet S2, Martinet N3, Lehotzky A4, Ovadi J4, Cuendet M1, Blanquart C5, Bertrand P6.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Nov 11. pii: S0960-894X(15)30220-1. doi: 10.1016/j.bmcl.2015.11.011. [Epub ahead of print]
Conditions for the metathesis of alkenes in the convergent synthesis of HDAC inhibitors have been improved by continuous catalyst flow injection in the reaction media. Intermediate and target compounds obtained were tested for their ability to induce HDAC inhibition and tubulin acetylation, revealin
PMID 26611919

Comparative plasma disposition kinetics of albendazole and its new benzimidazol prodrug in dog.

Khalil Z1, El Karbane M2, Faouzi ME3, Ansar M4, Azougagh M2, El Harti J4, Taoufik J4.
Annales pharmaceutiques francaises.Ann Pharm Fr.2015 Oct 31. pii: S0003-4509(15)00112-1. doi: 10.1016/j.pharma.2015.09.003. [Epub ahead of print]
The comparative pharmacokinetic behavior of albendazole (ABZ) and its new benzimidazol prodrug [1-tert-butyloxycarbonyl-5-propylthio-1-H-benzimidazol-2ylcarbamate of methyl] (ABZBoc), following their oral administration (10mg/kg) to healthy dogs was explored. Blood samples were obtained serially ove
PMID 26530448

Stereocontrolled Annulations of Indolo[2,3-a]quinolizidine-Derived Lactams with a Silylated Nazarov Reagent: Access to Allo and Epiallo Yohimbine-Type Derivatives.

Arioli F1, Pérez M1, Are C1, Estarellas C2, Luque FJ2, Bosch J1, Amat M3.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Sep 14;21(38):13382-9. doi: 10.1002/chem.201501912.
The facial selectivity of double Michael addition reactions of the silylated Nazarov reagent 4 to unsaturated indolo[2,3-a]quinolizidine lactams 3 has been studied. Pentacyclic 3-H/15-H trans adducts 5 are generated from Nind -unsubstituted lactams, but the corresponding cis isomers 6 are formed whe
PMID 26332232

Japanese Journal

Nakamura Mayumi,Iketani Aya,Shioi Yuzo
Mycoscience 52(4), 234-241, 2011-07-25
… Purification and characterization of protease were also carried out to identify a protease from Grifola frondosa using t-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumaryl-7-amide (Boc-LRR-MCA) as the substrate. …
NAID 10029296404

Atlantic Cod Trypsin-Catalyzed Peptide Synthesis with Inverse Substrates as Acyl Donor Components

Fuchise Tomoyoshi,Kishimura Hideki,Yang Zhi-Hong [他],Kojoma Mareshige,Toyota Eiko,Sekizaki Haruo
Chemical and Pharmaceutical Bulletin 58(4), 484-487, 2010
… Atlantic cod trypsin-catalyzed peptide synthesis has been studied by using p-amidino- and p-guanidinophenyl esters of N-(tert-butyloxycarbonyl)amino acid as acyl donor components. …
NAID 130000255943

Trypsin-Catalyzed Synthesis of Dipeptide Containing α-Aminoisobutylic Acid Using p- and m-(Amidinomethyl)phenyl Esters as Acyl Donor

Sekizaki Haruo,Itoh Kunihiko,Shibuya Akiyoshi [他],TOYOTA Eiko,KOJOMA Mareshige,TANIZAWA Kazutaka
Chemical & pharmaceutical bulletin 56(5), 688-691, 2008-05-01
… Two series of inverse substrates, p- and m-(amidinomethyl)phenyl esters derived from N-(tert-butyloxycarbonyl)amino acid, were prepared as acyl donor components for enzymatic peptide synthesis. …
NAID 110006663993