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Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics.

Fong DH, Berghuis AM.SourceDepartment of Biochemistry, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2009 Jul;53(7):3049-55. Epub 2009 May 11.
Butirosin is unique among the naturally occurring aminoglycosides, having a substituted amino group at position 1 (N1) of the 2-deoxystreptamine ring with an (S)-4-amino-2-hydroxybutyrate (AHB) group. While bacterial resistance to aminoglycosides can be ascribed chiefly to drug inactivation by plasm
PMID 19433564

Kudo F, Eguchi T.SourceDepartment of Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
Methods in enzymology.Methods Enzymol.2009;459:493-519.
Butirosin and neomycin belong to a family of clinically valuable 2-deoxystreptamine (2DOS)-containing aminoglycoside antibiotics. The biosynthetic gene clusters for butirosin and neomycin were identified in 2000 and in 2005, respectively. In recent years, most of the enzymes encoded in the gene clus
PMID 19362652

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Agricultural and Biological Chemistry 44(7), 1561-1566, 1980
… Properties of butirosin A resistant mutants derived from N. … A nonionic detergent, sodium dodecyl sulfate was found to be very effective on 3'-phosphorylation of xylostasin and butirosin A by intact cells. …
NAID 130003526894

Butirosin 3'-phosphotransferase from Bacillus vitellinus, a butirosin-producing organism.

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Agricultural and Biological Chemistry 41(12), 2437-2445, 1977
… Bacillus vitellinus, a butirosin-producing organism, was shown to possess butirosin 3'-phosphotransferase catalyzing the phosphorylation of butirosin A into butirosin A 3'-phosphate. … The enzyme was purified about 1200-fold from the cell-free extract of the organism by ammonium sulfate fractionation, affinity chromatography on butirosin A-Sepharose 4 B and two gel filtrations on Sephadex G-100. …
NAID 130003525585