English Journal

Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats.

Yang SJ1, Yu HY1, Kang DY1, Ma ZQ1, Qu R2, Fu Q3, Ma SP4.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2014 Aug 4. pii: S0091-3057(14)00219-6. doi: 10.1016/j.pbb.2014.07.015. [Epub ahead of print]
Salidroside (SA) is the primary bioactive marker compound in the standardized extracts from Rhodiola rosea. Although it has potential antidepressant activity in a rat behavioral despair model, the mechanisms of antidepressant effect for SA remain unclear. The objective of this study was to evaluate
PMID 25101546

Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice.

Islam MR1, Moriguchi S1, Tagashira H1, Fukunaga K2.
Neuroscience.Neuroscience.2014 Jul 11;272:116-30. doi: 10.1016/j.neuroscience.2014.04.046. Epub 2014 May 4.
Rivastigmine is a non-competitive inhibitor of both acetylcholinesterase (AChE) and butylcholinesterase (BuChE) used to treat mild to moderate dementia in Alzheimer's disease (AD) patients. Although rivastigmine reportedly ameliorates cognitive dysfunction in these patients, its ability to improve B
PMID 24797332

An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression.

Rodríguez-Gaztelumendi A1, Rojo ML, Pazos A, Díaz A.
Experimental brain research.Exp Brain Res.2014 Jun;232(6):1793-803. doi: 10.1007/s00221-014-3871-7. Epub 2014 Mar 1.
The olfactory bulbectomized (OB) rat, an animal model of chronic depression with comorbid anxiety, exhibits a profound dysregulation of the brain serotonergic signalling, a neurotransmission system involved in pain transmission and modulation. We here report an increased nociceptive response of OB r
PMID 24584836

Japanese Journal

The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

Yamamoto Yui,Shioda Norifumi,Han Feng [他],Moriguchi Shigeki,Fukunaga Kohji
Journal of Pharmacological Sciences 121(3), 212-226, 2013
… Acute intraperitoneal administration of ST101 (1 mg/kg, i.p.) improved memory-related behaviors in both olfactory bulbectomized (OBX) and scopolamine-treated mice. …
NAID 130003362685

塩田倫史,山本由似,韓峰 [他],森口茂樹,福永浩司
YAKUGAKU ZASSHI 131(4), 505-511, 2011
… We have recently found that olfactory bulbectomized (OBX) mice reveal memory impairment and depressive behaviors. …
NAID 130000678830

山本由似,塩田倫史,韓峰 [他],森口茂樹,福永浩司
YAKUGAKU ZASSHI 130(5), 717-721, 2010
… After olfactory bulbectomized (OBX), donepezil (1 or 3 mg/kg/day) was administered for 15 days and mouse brain was fixed with paraformaldehyde perfusion at day 18. …
NAID 130000259461