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a viral disease of sheep and cattle that is transmitted by biting midges

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/10 09:53:37」(JST)

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"Bluetongue" redirects here. For the lizard, see Blue-tongued lizard.

Bluetongue disease or catarrhal fever is a non-contagious, insect-borne, viral disease of ruminants, mainly sheep and less frequently cattle,^[1] goats, buffalo, deer, dromedaries and antelope. It is caused by the Bluetongue virus (BTV). The virus is transmitted by the midge Culicoides imicola, Culicoides variipennis and other culicoids.

Signs and symptoms

Infected sheep

A domestic yak infected with bluetongue virus. Tongue is swollen, cyanotic, and protruding from the mouth.

In sheep, BTV causes an acute disease with high morbidity and mortality. BTV also infects goats, cattle and other domestic animals as well as wild ruminants (for example, blesbuck, white-tailed deer, elk, and pronghorn antelope).^[2]

Major signs are high fever, excessive salivation, swelling of the face and tongue and cyanosis of the tongue. Swelling of the lips and tongue gives the tongue its typical blue appearance, though this sign is confined to a minority of the animals. Nasal symptoms may be prominent, with nasal discharge and stertorous respiration.

Some animals also develop foot lesions, beginning with coronitis, with consequent lameness. In sheep, this can lead to knee-walking. In cattle, constant changing of position of the feet gives bluetongue the nickname The Dancing Disease.^[3] Torsion of the neck (opisthotonos or torticollis) is observed in severely affected animals.

Not all animals develop symptoms, but all those that do lose condition rapidly, and the sickest die within a week. For affected animals which do not die, recovery is very slow, lasting several months.

The incubation period is 5–20 days, and all symptoms usually develop within a month. The mortality rate is normally low, but it is high in susceptible breeds of sheep. In Africa, local breeds of sheep may have no mortality, but in imported breeds it may be up to 90 percent.^[4]

In cattle, goats and wild ruminants infection is usually asymptomatic despite high virus levels in blood. Red deer are an exception, and in them the disease may be as acute as in sheep.^[5]

Microbiology

Bluetongue is caused by the pathogenic virus, Bluetongue virus (BTV),^[2] of the genus Orbivirus, of the Reoviridae family. Twenty-six serotypes are now recognised for this virus.^[6]

The virus particle consists of ten strands of double-stranded RNA surrounded by two protein shells. Unlike other arboviruses, BTV lacks a lipid envelope. The particle has a diameter of 86 nm.^[7] The structure of the 70 nm core was determined in 1998 and was at the time the largest atomic structure to be solved.^[8]

The two outer capsid proteins, VP2 and VP5, mediate attachment and penetration of BTV into the target cell. The virus makes initial contact with the cell with VP2, triggering receptor-mediated endocytosis of the virus. The low pH within the endosome then triggers BTV's membrane penetration protein VP5 to undergo a conformational change that disrupts the endosomal membrane.^[7] Uncoating yields a transcriptionally active 470S core particle which is composed of two major proteins VP7 and VP3, and the three minor proteins VP1, VP4 and VP6 in addition to the dsRNA genome. There is no evidence that any trace of the outer capsid remains associated with these cores, as has been described for reovirus. The cores may be further uncoated to form 390S subcore particles that lack VP7, also in contrast to reovirus. Subviral particles are probably akin to cores derived in vitro from virions by physical or proteolytic treatments that remove the outer capsid and causes activation of the BTV transcriptase. In addition to the seven structural proteins, three non-structural (NS) proteins, NS1, NS2, NS3 (and a related NS3A) are synthesised in BTV-infected cells. Of these, NS3/NS3A is involved in the egress of the progeny virus. The two remaining non-structural proteins, NS1 and NS2, are produced at high levels in the cytoplasm and are believed to be involved in virus replication, assembly and morphogenesis.^[2]

Epidemiology

The molecular epidemiology of bluetongue virus (BTV) in Europe since 1998: routes of introduction of different serotypes and individual virus strains.

Bluetongue has been observed in Australia, the USA, Africa, the Middle East, Asia and Europe. Its occurrence is seasonal in the affected Mediterranean countries, subsiding when temperatures drop and hard frosts kill the adult midge vectors.^[9] which may promote viral survival and vector longevity during milder winters.^[10] A significant contribution to the northward spread of Bluetongue disease has been the ability of Culicoides obsoletus and C.pulicaris to acquire and transmit the disease, both of which are spread widely throughout Europe. This is in contrast to the original C.imicola vector which is limited to North Africa and the Mediterranean. The relatively recent novel vector has facilitated a far more rapid spread than the simple expansion of habitats North through global warming.^{[citation needed]} In August 2006, cases of bluetongue were found in the Netherlands, then Belgium, Germany, and Luxembourg.^[11]^[12] In 2007, the first case of bluetongue in the Czech Republic was detected in one bull near Cheb at the Czech-German border.^[13] In September 2007, the UK reported its first ever suspected case of the disease, in a Highland cow on a rare breeds farm near Ipswich, Suffolk.^[14] Since then the virus has spread from cattle to sheep in Britain.^[15] By October 2007 bluetongue had become a serious threat in Scandinavia and Switzerland^[16] and the first outbreak in Denmark was reported.^[17] In autumn 2008, several cases were reported in the southern Swedish provinces of Småland, Halland, and Skåne,^[18] as well as in areas of the Netherlands bordering Germany, prompting veterinary authorities in Germany to intensify controls.^[19] Norway saw its first finding in February 2009, when cows at two farms in Vest-Agder in the south of Norway showed an immune response to bluetongue.^[20] Norway have since been declared free of the disease in 2011.

Although the disease is not a threat to humans the most vulnerable common domestic ruminants in the UK are cattle, goats and, especially, sheep.

Overwintering

A puzzling aspect of BTV is its survival between midge seasons in temperate regions. Adult Culicoides are killed by cold winter temperatures, and BTV infections typically do not last for more than 60 days, which is not long enough for BTV to last until the next spring. It is believed that the virus somehow survives in overwintering midges or animals. Multiple mechanisms have been proposed. A few adult Culicoides midges infected with BTV may survive the mild winters of the temperate zone. Some midges may even move indoors to avoid the cold temperature of the winter. Additionally, BTV could cause a chronic or latent infection in some animals, providing another means for BTV to survive the winter. BTV can also be transmitted from mother to fetus. The outcome is abortion or stillbirth if fetal infection occurs early in gestation and survival if infection occurs late. However infection at an intermediate stage, before the fetal immune system is fully developed, may result in a chronic infection that lingers until the first months after birth of the lamb. Midges will then spread the disease from the calves to other animals, starting a new season of infection.^[21]

Treatment and prevention

There is no efficient treatment. Prevention is effected via quarantine, inoculation with live modified virus vaccine and control of the midge vector, including inspection of aircraft.

Livestock management and insect control

However, simple husbandry changes and practical midge control measures may help break the livestock infection cycle. Housing livestock during times of maximum midge activity (from dusk to dawn) may lead to significantly reduced biting rates. Similarly, protecting livestock shelters with fine mesh netting or coarser material impregnated with insecticide will reduce contact with the midges. The Culicoides midges that carry the virus usually breed on animal dung and moist soils, either bare or covered in short grass. Identifying breeding grounds and breaking the breeding cycle will significantly reduce the local midge population. Turning off taps, mending leaks and filling in or draining damp areas will also help dry up breeding sites.^[22] Control by trapping midges and removing their breeding grounds may reduce vector numbers. Dung heaps or slurry pits should be covered or removed, and their perimeters (where most larvae are found) regularly scraped.^[23]

Vaccines

Outbreaks in southern Europe have been caused by serotypes 2 and 4, and vaccines are available against these serotypes (ATCvet codes: QI04AA02 for sheep, QI02AA08 for cattle). However, the disease found in northern Europe (including the UK) in 2006 and 2007 has been caused by serotype 8. Vaccine companies Fort Dodge Animal Health (Wyeth), Merial and Intervet were developing vaccines against serotype 8 (Fort Dodge Animal Health has serotype 4 for sheep, serotype 1 for sheep and cattle and serotype 8 for sheep and cattle) and the associated production facilities. A vaccine for this is now available in the UK, produced by Intervet. Fort Dodge Animal Health has their vaccines available for multiple European Countries (vaccination will start in 2008 in Germany, Belgium, Switzerland, Spain and Italy). However, immunization with any of the available vaccines preclude later serological monitoring of affected cattle populations, a problem which could be resolved using next-generation subunit vaccines currently in development. ^[24]

History

Although bluetongue disease was already recognized in South Africa in the early 19th century, a comprehensive description of the disease was not published until the first decade of the 20th century.^[25] In 1906 Arnold Theiler showed that bluetongue was caused by a filterable agent. He also created the first bluetongue vaccine, which was developed from an attenuated BTV strain.^[26] For many decades bluetongue was thought to be confined to Africa. The first confirmed outbreak outside of Africa occurred in Cyprus in 1943.^[25]

Related diseases

African horse sickness is related to Bluetongue and is spread by the same midges (Culicoides species). It can kill the horses it infects and mortality may go as high as 90% of the infected horses during an epidemic.^[27]

The Epizootic Hemorrhagic Disease (EHD) virus is closely related and crossreacts with Bluetongue virus on many blood tests.

References

^ "Q&A: Bluetongue disease". BBC. 2008-09-17. Retrieved 2010-01-01.
^ ^a ^b ^c Roy P (2008). "Molecular Dissection of Bluetongue Virus". Animal Viruses: Molecular Biology. Caister Academic Press. pp. 305–354. ISBN 978-1-904455-22-6.
^ McGrath, Matt (Last Updated:). "'Dancing' disease set for long run". BBC News. Retrieved 2008-10-24. Check date values in: |date= (help)
^ Handbook of Animal Diseases in the Tropics, 1976. ISBN 0-901028-10-X
^ Jensen, R. and Swift, B.L. Diseases of Sheep, Lea and Febiger, Philadelphia, 1982. ISBN 0-8121-0836-1
^ Maan S, Maan NS, Nomikou K, Veronesi E, Bachanek-Bankowska K, Belaganahalli MN, Attoui H, Mertens PP (2011) Complete genome characterisation of a novel 26th bluetongue virus serotype from Kuwait. PLoS One. 2011;6(10):e26147.
^ ^a ^b Roy P (2008). "Functional mapping of bluetongue virus proteins and their interactions with host proteins during virus replication". Cell Biochemistry and Biophysics 50 (3): 143–57. doi:10.1007/s12013-008-9009-4. PMID 18299997.
^ Rossmann MG, Tao Y (March 1999). "Courageous science: structural studies of bluetongue virus core". Structure (London, England : 1993) 7 (3): R43–6. PMID 10368304.
^ Purse, Bethan V.; Mellor, Philip S.; Rogers, David J.; Samuel, Alan R.; Mertens, Peter P. C.; and Baylis, Matthew (February 2005). "Climate change and the recent emergence of bluetongue in Europe". Nature Reviews Microbiology 3 (2): 171–181. doi:10.1038/nrmicro1090. PMID 15685226. Cite uses deprecated parameters (help)
^ "Bluetongue – Europe (51)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.
^ "Blue Tongue confirmed in Belgium and Germany" (Press release). European Commission. 2006-08-21. Retrieved 2006-08-21.
^ "Lethal horse disease knocking on Europe's door" (Press release). Horsetalk.co.nz. 2007-03-28. Retrieved 2007-03-27.
^ "Bluetongue dobývá Evropskou unii". Agroweb. 2008-02-19. Retrieved 2008-05-29.
^ "Bluetongue disease detected in UK". BBC News Online. 2007-09-22. Retrieved 2007-09-22.
^ Gray, Richard (2007-10-14). "Bluetongue spreads from cattle to sheep". London: Telegraph.co.uk. Retrieved 2007-10-15.
^ "Bluetongue – Europe (50)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.
^ "Bluetongue outbreak detected in Denmark – EU", Reuters, 13 October 2007.
^ "Blue tongue outbreak spreads south". Thelocal.se. 2008-09-24. Retrieved 2008-09-24.
^ "Blauzungenkrankheit in Niederlanden wieder ausgebrochen". Westdeutscher Rundfunk. 2008-09-26. Retrieved 2008-09-27.
^ Veterinærinstituttet informs about the outbreak in Vest-Agder, Norway National Veterinary Institute, 20 February 2009.
^ Wilson A, Darpel K, Mellor PS (August 2008). "Where does bluetongue virus sleep in the winter?". Plos Biology 6 (8): e210. doi:10.1371/journal.pbio.0060210. PMC 2525685. PMID 18752350.
^ Gairdner, Julie. "Bluetongue (blue tongue) outbreak in the UK – FWi's special report", Farmers Weekly, 24 September 2007. Offers practical advice for preventing Bluetongue in livestock.
^ Abel, Charles. "Bluetongue vaccine BTV8 questions answered", Farmers Weekly, 2 April 2008.
^ Anderson J, Hägglund S, Bréard E, Comtet L, Lövgren Bengtsson K, Pringle J, Zientara S, Valarcher JF (2013). "Evaluation of the immunogenicity of an experimental DIVA subunit vaccine against Bluetongue virus serotype 8 in cattle". Clinical and vaccine immunology. doi:10.1128/CVI.00229-13. PMID 23720365.
^ ^a ^b Mertens, Peter (2009). Bluetongue (Biology of Animal Infections) (1 ed.). Academic Press. pp. 7–21. ISBN 978-0123693686.
^ Maclachlan NJ (November 2011). "Bluetongue: history, global epidemiology, and pathogenesis". Preventive Veterinary Medicine 102 (2): 107–11. doi:10.1016/j.prevetmed.2011.04.005. PMID 21570141.
^ African Horse Sickness – Clinical Findings and Lesions, The Merck Veterinary Manual.

External links

Wikimedia Commons has media related to Bluetongue disease.

Introduction to disease in The Merck Veterinary Manual
Bluetongue page from OIE
Bluetongue UK government page from Defra
Bluetongue page on warmwell.com
Canadian Food Inspection Agency (CFIA) Animal Disease Information
- Bluetongue disease fact sheet
- Biosecurity training video
- Farm-level biosecurity practices
Takamatsu, H., Mellor, P. S., and others. (2003). "A possible overwintering mechanism for bluetongue virus in the absence of the insect vector". Journal of General Virology 84: 227–235.
News and announcements on the Bluetongue outbreak in the UK, Farmers Guardian

English Journal

Bluetongue serotype 2 and 9 modified live vaccine viruses as causative agents of abortion in livestock: a retrospective analysis in Italy.

Savini G, Lorusso A, Paladini C, Migliaccio P, Di Gennaro A, Di Provvido A, Scacchia M, Monaco F.Author information Department of Virology, OIE Reference Laboratory for Bluetongue, Istituto G. Caporale, Teramo, Italy.AbstractThe recent outbreak caused by Schmallenberg virus, which affected sheep, goats and cattle in Europe, highlighted the importance of having a robust surveillance plan capable of monitoring abortions and malformations in the livestock offspring. In this context, bluetongue viruses (BTVs) represented and represent one of the major threats to the European livestock industry. Aiming to improve the understanding on BTV cross placental transmission and serotype involvement, in this retrospective study foetal spleens and/or brains of 663 ovines, 429 bovines, 155 goats and 17 buffaloes were tested for the presence of BTV by virus isolation. BTV vaccine strains were isolated from 31 foetuses (2.4%; 95% CI: 1.7-3.4%): 24 (3.6%; 95% CI: 2.4-5.3%) from ovine foetal tissues; 6 (1.4%; 95% CI: 0.6-3.0%) from bovine foetal tissues and 1 (0.6%; 95% CI: 0.2-3.5%) from the spleen of a caprine foetus. All foetuses were from animals vaccinated with either BTV-2 or BTV-2, and BTV-9 modified live vaccines (MLVs) produced by Onderstepoort Biological Products (OBP), South Africa. Among the 31 isolated vaccine strains, serotype 9 (n = 28) was more frequently isolated (P < 0.05) than serotype 2 (n = 3). In two cases infectious vaccine strains were found in the foetal tissues 2 months after the vaccine administration. Other pathogens known to be causative agents of abortion in ruminants were not detected nor isolated. This study demonstrates, for the first time, that BTV-2 and BTV-9 vaccine strains are able to cross the placental barrier of sheep, cattle and goats. BTV-2 and BTV-9 vaccine strains are able to infect foetuses and cause abortions or malformations depending on the period of pregnancy at the time of vaccination.
Transboundary and emerging diseases.Transbound Emerg Dis.2014 Feb;61(1):69-74. doi: 10.1111/tbed.12004. Epub 2012 Sep 3.
The recent outbreak caused by Schmallenberg virus, which affected sheep, goats and cattle in Europe, highlighted the importance of having a robust surveillance plan capable of monitoring abortions and malformations in the livestock offspring. In this context, bluetongue viruses (BTVs) represented an
PMID 22937914

Detrimental effect of cypermethrin treated nets on Culicoides populations (Diptera; Ceratopogonidae) and non-targeted fauna in livestock farms.

Del Río R1, Barceló C2, Lucientes J3, Miranda MA2.Author information 1Laboratory of Zoology, University of the Balearic Islands (UIB), Cra. Valldemossa Km. 7.5, Palma de Mallorca, Spain. Electronic address: ricardo.delrio@uib.es.2Laboratory of Zoology, University of the Balearic Islands (UIB), Cra. Valldemossa Km. 7.5, Palma de Mallorca, Spain.3Department of Animal Pathology, Faculty of Veterinary Science, University of Zaragoza, Zaragoza, Spain.AbstractBluetongue (BT) is an important disease of ruminants which exhibits its most severe clinical signs on cattle and especially on certain breeds of sheep. The known vectors of BT are small insects of the genus Culicoides (Diptera; Ceratopogonidae). Two species from this genus - Culicoides imicola and Culicoides obsoletus - play the major role in the transmission of the disease in Europe. Several prophylactic methods are used to avoid transmission; however, an easy and cost-effective preventive technique would be very useful for the control of the Culicoides populations near the animals. In the present study, the insecticide effect of cypermethrin treated nets on a Culicoides population was evaluated. A polyethylene net sprayed with 1L cypermethrin solution (1%) surrounding a UV light suction trap was placed at a cattle farm in Majorca (Balearic Islands). Collections of Culicoides and other fauna from the trap and floor around the net were compared with a control. Results showed no significant differences in the collection of Culicoides midges between the insecticide-treated net and the control. However, significant differences were observed in the collection of the non-target fauna between the treated net and the control, indicating that the dose used in the present trial was enough to kill most of the arthropods that contacted the net. The reasons for these equivocal findings and means to improve this technique for the control of Culicoides midges are discussed.
Veterinary parasitology.Vet Parasitol.2014 Jan 31;199(3-4):230-4. doi: 10.1016/j.vetpar.2013.10.014. Epub 2013 Oct 26.
Bluetongue (BT) is an important disease of ruminants which exhibits its most severe clinical signs on cattle and especially on certain breeds of sheep. The known vectors of BT are small insects of the genus Culicoides (Diptera; Ceratopogonidae). Two species from this genus - Culicoides imicola and C
PMID 24238622

A SYBR Green I based real time RT-PCR assay for specific detection and quantitation of Peste des petits ruminants virus.

Abera T, Thangavelu A, Joy Chandran ND, Raja A.AbstractBACKGROUND: Peste des petits ruminants (PPR) is an economically important disease of small ruminants such as sheep and goats. The disease is characterized by severe pyrexia, oculo-nasal discharge, pneumonia, necrosis and ulceration of the mucous membrane and inflammation of the gastro-intestinal tract leading to severe diarrhea. A SYBR Green I based real time RT-PCR targeting the N gene of PPRV has not been established for PPRV detection. Thus, the objective of present study was to develop highly sensitive N gene target SYBR Green I real time RT-PCR for specific detection and quantification of PPRV in clinical samples. A set of primers was designed to detect the nucleocapsid (N) gene of PPRV.
BMC veterinary research.BMC Vet Res.2014 Jan 14;10(1):22. [Epub ahead of print]
BACKGROUND: Peste des petits ruminants (PPR) is an economically important disease of small ruminants such as sheep and goats. The disease is characterized by severe pyrexia, oculo-nasal discharge, pneumonia, necrosis and ulceration of the mucous membrane and inflammation of the gastro-intestinal tra
PMID 24423231

Japanese Journal

Virology: Expression and characterization of bluetongue virus serotype 21 VP7 antigen: C-terminal truncated protein has significantly reduced antigenicity

Hosamani Madhusudan,Shimizu Shinya,Hirota Jiro [他]
日本獣醫學会会誌 73(5), 609-613, 2011-05
NAID 40018864923

Detection of Culicoides brevitarsis Activity in Kyushu

YANASE Tohru,HIRATA Miki,MATSUMORI Yoichi,MATSUMURA Masaya,KATO Tomoko,SHIRAFUJI Hiroaki,YAMAKAWA Makoto,HAYAMA Yoko,TSUTSUI Toshiyuki
Journal of Veterinary Medical Science 73(12), 1649-1652, 2011
… transmits important ruminant arboviruses, such as Akabane, Aino and bluetongue viruses. …
NAID 130001032754

Expression and Characterization of Bluetongue Virus Serotype 21 VP7 Antigen: C-Terminal Truncated Protein has Significantly Reduced Antigenicity

HOSAMANI Madhusudan,SHIMIZU Shinya,HIROTA Jiro,KOKUHO Takehiro,KUBOTA Takayuki,WATANABE Satoko,OHTA Masato,MUNETA Yoshihiro,INUMARU Shigeki
Journal of Veterinary Medical Science 73(5), 609-613, 2011
… In the present study, group-specific antigen VP7 of bluetongue virus (BTV) serotype 21 isolated from cattle in Tochigi prefecture in Japan in 1994 was characterized by sequencing and expression. …
NAID 130000444746

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リンク元	「ブルータング」
拡張検索	「bluetongue virus」

「ブルータング」

Bluetongue virus
	Electron micrograph of Bluetongue virus. Scale bar = 50 nm.
Virus classification
Group:	Group III (dsRNA)
Order:	Unassigned
Family:	Reoviridae
Genus:	Orbivirus
Species:	Bluetongue virus

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「bluetongue virus」

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関: blue tongue virus

[1] "Q&A: Bluetongue disease". BBC. 2008-09-17. Retrieved 2010-01-01.

[roy-2] Roy P (2008). "Molecular Dissection of Bluetongue Virus". Animal Viruses: Molecular Biology. Caister Academic Press. pp. 305–354. ISBN 978-1-904455-22-6.

[3] McGrath, Matt (Last Updated:). "'Dancing' disease set for long run". BBC News. Retrieved 2008-10-24. Check date values in: |date= (help)

[4] Handbook of Animal Diseases in the Tropics, 1976. ISBN 0-901028-10-X

[5] Jensen, R. and Swift, B.L. Diseases of Sheep, Lea and Febiger, Philadelphia, 1982. ISBN 0-8121-0836-1

[Maan2011-6] Maan S, Maan NS, Nomikou K, Veronesi E, Bachanek-Bankowska K, Belaganahalli MN, Attoui H, Mertens PP (2011) Complete genome characterisation of a novel 26th bluetongue virus serotype from Kuwait. PLoS One. 2011;6(10):e26147.

[Roy2008-7] Roy P (2008). "Functional mapping of bluetongue virus proteins and their interactions with host proteins during virus replication". Cell Biochemistry and Biophysics 50 (3): 143–57. doi:10.1007/s12013-008-9009-4. PMID 18299997.

[Rossmann1999-8] Rossmann MG, Tao Y (March 1999). "Courageous science: structural studies of bluetongue virus core". Structure (London, England : 1993) 7 (3): R43–6. PMID 10368304.

[9] Purse, Bethan V.; Mellor, Philip S.; Rogers, David J.; Samuel, Alan R.; Mertens, Peter P. C.; and Baylis, Matthew (February 2005). "Climate change and the recent emergence of bluetongue in Europe". Nature Reviews Microbiology 3 (2): 171–181. doi:10.1038/nrmicro1090. PMID 15685226. Cite uses deprecated parameters (help)

[10] "Bluetongue – Europe (51)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.

[11] "Blue Tongue confirmed in Belgium and Germany" (Press release). European Commission. 2006-08-21. Retrieved 2006-08-21.

[jdfxyd-12] "Lethal horse disease knocking on Europe's door" (Press release). Horsetalk.co.nz. 2007-03-28. Retrieved 2007-03-27.

[13] "Bluetongue dobývá Evropskou unii". Agroweb. 2008-02-19. Retrieved 2008-05-29.

[14] "Bluetongue disease detected in UK". BBC News Online. 2007-09-22. Retrieved 2007-09-22.

[15] Gray, Richard (2007-10-14). "Bluetongue spreads from cattle to sheep". London: Telegraph.co.uk. Retrieved 2007-10-15.

[16] "Bluetongue – Europe (50)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.

[17] "Bluetongue outbreak detected in Denmark – EU", Reuters, 13 October 2007.

[18] "Blue tongue outbreak spreads south". Thelocal.se. 2008-09-24. Retrieved 2008-09-24.

[19] "Blauzungenkrankheit in Niederlanden wieder ausgebrochen". Westdeutscher Rundfunk. 2008-09-26. Retrieved 2008-09-27.

[20] Veterinærinstituttet informs about the outbreak in Vest-Agder, Norway National Veterinary Institute, 20 February 2009.

[Wilson2008-21] Wilson A, Darpel K, Mellor PS (August 2008). "Where does bluetongue virus sleep in the winter?". Plos Biology 6 (8): e210. doi:10.1371/journal.pbio.0060210. PMC 2525685. PMID 18752350.

[22] Gairdner, Julie. "Bluetongue (blue tongue) outbreak in the UK – FWi's special report", Farmers Weekly, 24 September 2007. Offers practical advice for preventing Bluetongue in livestock.

[23] Abel, Charles. "Bluetongue vaccine BTV8 questions answered", Farmers Weekly, 2 April 2008.

[ANDERSON_2013-24] Anderson J, Hägglund S, Bréard E, Comtet L, Lövgren Bengtsson K, Pringle J, Zientara S, Valarcher JF (2013). "Evaluation of the immunogenicity of an experimental DIVA subunit vaccine against Bluetongue virus serotype 8 in cattle". Clinical and vaccine immunology. doi:10.1128/CVI.00229-13. PMID 23720365.

[Mertens2009history-25] Mertens, Peter (2009). Bluetongue (Biology of Animal Infections) (1 ed.). Academic Press. pp. 7–21. ISBN 978-0123693686.

[Maclachlan2011-26] Maclachlan NJ (November 2011). "Bluetongue: history, global epidemiology, and pathogenesis". Preventive Veterinary Medicine 102 (2): 107–11. doi:10.1016/j.prevetmed.2011.04.005. PMID 21570141.

[Merck-27] African Horse Sickness – Clinical Findings and Lesions, The Merck Veterinary Manual.

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