- 関
- bleomycin、bleomycin sulfate
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
UpToDate Contents
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English Journal
- Pingyangmycin-regulated expressions of adhesion molecules in human venous malformation endothelial cells.
- Jia Y, Jia J, Zhao Y.SourceDepartment of Oral and Maxillofacial Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, Jiayulin163@163.com.
- Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.J Huazhong Univ Sci Technolog Med Sci.2012 Oct;32(5):760-6. doi: 10.1007/s11596-012-1031-5. Epub 2012 Oct 18.
- Pingyangmycin (bleomycin A5 hydrochloride, PYM) is one of the anti-neoplastic agents which have been commonly used to treat venous malformations. However, the underlying mechanism by which PYM treats venous malformations remains poorly understood. It was reported that venous endothelial cells could
- PMID 23073810
- Ghrelin Suppression and Fat Loss after Left Gastric Artery Embolization in Canine Model.
- Bawudun D, Xing Y, Liu WY, Huang YJ, Ren WX, Ma M, Xu XD, Teng GJ.SourceDepartment of Interventional Radiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
- Cardiovascular and interventional radiology.Cardiovasc Intervent Radiol.2012 Feb 25. [Epub ahead of print]
- PURPOSE: To evaluate the effects of left gastric artery embolization (LGAE) on plasma ghrelin levels, abdominal fat, and body weight in beagles.METHODS: The institutional animal care and use committee approved this study. Fifteen healthy adult beagles (12 male and three female animals) were randomly
- PMID 22367009
Japanese Journal
- 田中 英一郎,高塚 純子,竹之内 辰也
- Skin Cancer 19(3), 336-339, 2004
- 放射線を扱う医療従事者に生じた有棘細胞癌の1例を経験した。87歳男。砒素暴露歴なし。元内科医師。現役時代X線を用いた検査の際, 無防備に両手を放射線に暴露していた。初診の10年前より両手指に角化性病変と潰瘍を形成し, その後右中指の潰瘍が急速に隆起して腫瘤を形成。慢性放射線皮膚炎から発生した有棘細胞癌と診断し, 局麻下にPIP関節離断術を施行した。角化を伴う異型性の強い腫瘍細胞の骨まで達する浸潤性 …
- NAID 130001078612
- 伴野 富美子,斉藤 昭二,土屋 敏行,萩原 雄二
- 環境変異原研究 20(1), 19-27, 1998-04-10
- … The standard mutagens used were 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, benzo(a)pyrene, 2-aminoanthracene, 9-aminoacridine hydrochloride monohydrate, sodium azide and bleomycin hydrochloride. …
- NAID 110001710386
Related Links
- chemBlink provides information about CAS # 67763-87-5, Bleomycin hydrochloride.
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★リンクテーブル★
[★]
- 英
- bleomycin, BLM
- ラ
- bleomycinum
- 化
- 塩酸ブレオマイシン bleomycin hydrochloride、硫酸ブレオマイシン bleomycin sulfate
- 商
- Blenoxane、ブレオ Bleo
- 関
- 抗腫瘍性抗生物質製剤
- first aid step1 2006 p.207,307,308,309
特徴
構造
作用機序
- induces formation of free radicals, which cause breaks in DNA strands
- Fe2+を結合し、O2に電子を与えてhydrogen radicalを作り、1本鎖DNA、2本鎖DNAを切断
- G2期特異的。細胞周期非特異的?
薬理作用
- 扁平上皮癌に強い作用
- ブレオマイシンはhydrolaseにより分解されるが、この酵素は皮膚と肺で少ない → 作用スペクトルや副作用に関係
動態
適応
注意
禁忌
副作用
- 骨髄抑制がほとんど無い!
- 肝、骨髄などで速やかに不活性化される → 造血器官、肝、腎障害:少 急性毒性:極低
[★]
- 関
- bleomycin、bleomycin hydrochloride、phleomycin
[★]
- 英
- bleomycin hydrochloride
- 関
- ブレオマイシン
[★]
塩酸塩、ハイドロクロライド
[★]
ブレオマイシン
- 同
- Blenoxane