English Journal

Estrogen exhibits a biphasic effect on prostate tumor growth through the ERβ-KLF5 pathway.

Nakajima Y1, Osakabe A2, Waku T3, Suzuki T4, Akaogi K2, Fujimura T5, Homma Y5, Inoue S6, Yanagisawa J7.
Molecular and cellular biology.Mol Cell Biol.2015 Oct 19. pii: MCB.00625-15. [Epub ahead of print]
Estrogens are effective in the treatment of prostate cancer; however, the effects of estrogens on prostate cancer are enigmatic. In this study, we demonstrated that estrogen (17β-estradiol, E2) has biphasic effects on prostate tumor growth. A lower dose of E2 increased tumor growth in mouse xenogra
PMID 26483416

Shin WS1, Na HW1, Lee ST2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Oct;1853(10 Pt A):2251-60. doi: 10.1016/j.bbamcr.2015.05.015. Epub 2015 May 16.
Protein tyrosine kinase 7 (PTK7) is a member of the defective receptor protein tyrosine kinase family which lacks catalytic activity. Expression of PTK7 is increased in various cancers but its role in carcinogenesis is not well understood. We previously showed that disruption of PTK7 function suppre
PMID 25986862

Sundstrøm T1, Espedal H1, Harter PN1, Fasmer KE1, Skaftnesmo KO1, Horn S1, Hodneland E1, Mittelbronn M1, Weide B1, Beschorner R1, Bender B1, Rygh CB1, Lund-Johansen M1, Bjerkvig R1, Thorsen F1.
Neuro-oncology.Neuro Oncol.2015 Oct;17(10):1374-85. doi: 10.1093/neuonc/nov040. Epub 2015 Mar 19.
BACKGROUND: The key metabolic enzyme lactate dehydrogenase A (LDHA) is overexpressed in many cancers, and several preclinical studies have shown encouraging results of targeted inhibition. However, the mechanistic importance of LDHA in melanoma is largely unknown and hitherto unexplored in brain met
PMID 25791837