生物工学的な、生物工学の、バイオテクノロジーの

関: bioengineering、biotech、biotechnology

WordNet

the branch of engineering science in which biological science is used to study the relation between workers and their environments (同)bioengineering, ergonomics
the branch of molecular biology that studies the use of microorganisms to perform specific industrial processes; "biotechnology produced genetically altered bacteria that solved the problem" (同)biotech

PrepTutorEJDIC

《米》生物工学,人間工学)人が機械で最も能率的に仕事をするための研究)(《英》ergonomics)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/12/06 23:43:06」(JST)

wiki en

[Wiki en表示]

Insulin crystals

Biotechnology is the broad area of biology involving living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2).^[1] Depending on the tools and applications, it often overlaps with the (related) fields of molecular biology, bio-engineering, biomedical engineering, biomanufacturing, molecular engineering, etc.

For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine.^[2] The term is largely believed to have been coined in 1919 by Hungarian engineer Károly Ereky. In the late 20th and early 21st centuries, biotechnology has expanded to include new and diverse sciences such as genomics, recombinant gene techniques, applied immunology, and development of pharmaceutical therapies and diagnostic tests.^[2]

Definitions

The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock.^[3] Per the European Federation of Biotechnology, biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services.^[4] Biotechnology is based on the basic biological sciences (e.g. molecular biology, biochemistry, cell biology, embryology, genetics, microbiology) and conversely provides methods to support and perform basic research in biology.

Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis, for example), forecasted, formulated, developed, manufactured, and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).^[5]^[6]^[7] The utilization of biological processes, organisms or systems to produce products that are anticipated to improve human lives is termed biotechnology.^[8]

By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly) for interfacing with and utilizing living things. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals.^[9] Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical or chemical engineering such as tissue engineering, biopharmaceutical engineering, and genetic engineering.

History

Brewing was an early application of biotechnology

Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit the broad definition of "'utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise.

Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best suited crops, having the highest yields, to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize, restore nitrogen, and control pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants — one of the first forms of biotechnology.

These processes also were included in early fermentation of beer.^[10] These processes were introduced in early Mesopotamia, Egypt, China and India, and still use the same basic biological methods. In brewing, malted grains (containing enzymes) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in the grains broke down into alcohols, such as ethanol. Later, other cultures produced the process of lactic acid fermentation, which produced other preserved foods, such as soy sauce. Fermentation was also used in this time period to produce leavened bread. Although the process of fermentation was not fully understood until Louis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.

Before the time of Charles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.^[11]

For thousands of years, humans have used selective breeding to improve production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.^[12]

In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used a pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum, to produce acetone, which the United Kingdom desperately needed to manufacture explosives during World War I.^[13]

Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium. His work led to the purification of the antibiotic compound formed by the mold by Howard Florey, Ernst Boris Chain and Norman Heatley – to form what we today know as penicillin. In 1940, penicillin became available for medicinal use to treat bacterial infections in humans.^[12]

The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced the new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty.^[14] Indian-born Ananda Chakrabarty, working for General Electric, had modified a bacterium (of the genus Pseudomonas) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium.

Revenue in the industry is expected to grow by 12.9% in 2008.

Another factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products to cope with an ageing, and ailing, U.S. population.^[15]

Rising demand for biofuels is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production.^[16]

Examples

A rose plant that began as cells grown in a tissue culture

Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g. biodegradable plastics, vegetable oil, biofuels), and environmental uses.

For example, one application of biotechnology is the directed use of organisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching. Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities (bioremediation), and also to produce biological weapons.

A series of derived terms have been coined to identify several branches of biotechnology, for example:

Bioinformatics (also called "gold biotechnology) is an interdisciplinary field that addresses biological problems using computational techniques, and makes the rapid organization as well as analysis of biological data possible. The field may also be referred to as computational biology, and can be defined as, "conceptualizing biology in terms of molecules and then applying informatics techniques to understand and organize the information associated with these molecules, on a large scale."^[17] Bioinformatics plays a key role in various areas, such as functional genomics, structural genomics, and proteomics, and forms a key component in the biotechnology and pharmaceutical sector.^[18]
Blue biotechnology is based on the exploitation of sea resources to create products and industrial applications.^[19] This branch of biotechnology is the most used for the industries of refining and combustion principally on the production of bio-oils with photosynthetic micro-algae.^[19]^[20]
Green biotechnology is biotechnology applied to agricultural processes. An example would be the selection and domestication of plants via micropropagation. Another example is the designing of transgenic plants to grow under specific environments in the presence (or absence) of chemicals. One hope is that green biotechnology might produce more environmentally friendly solutions than traditional industrial agriculture. An example of this is the engineering of a plant to express a pesticide, thereby ending the need of external application of pesticides. An example of this would be Bt corn. Whether or not green biotechnology products such as this are ultimately more environmentally friendly is a topic of considerable debate.^[19] It is commonly considered as the next phase of green revolution, which can be seen as a platform to eradicate world hunger by using technologies which enable the production of more fertile and resistant, towards biotic and abiotic stress, plants and ensures application of environmentally friendly fertilizers and the use of biopesticides, it is mainly focused on the development of agriculture.^[19] On the other hand, some of the uses of green biotechnology involve microorganisms to clean and reduce waste.^[21]^[19]
Red biotechnology is the use of biotechnology in the medical and pharmaceutical industries, and health preservation.^[19] This branch involves the production of vaccines and antibiotics, regenerative therapies, creation of artificial organs and new diagnostics of diseases.^[19] As well as the development of hormones, stem cells, antibodies, siRNA and diagnostic tests.^[19]
White biotechnology, also known as industrial biotechnology, is biotechnology applied to industrial processes. An example is the designing of an organism to produce a useful chemical. Another example is the using of enzymes as industrial catalysts to either produce valuable chemicals or destroy hazardous/polluting chemicals. White biotechnology tends to consume less in resources than traditional processes used to produce industrial goods.^[22]^[23]
"Yellow biotechnology" refers to the use of biotechnology in food production, for example in making wine, cheese, and beer by fermentation.^[19] It has also been used to refer to biotechnology applied to insects. This includes biotechnology-based approaches for the control of harmful insects, the characterisation and utilisation of active ingredients or genes of insects for research, or application in agriculture and medicine and various other approaches.^[24]
Gray biotechnology is dedicated to environmental applications, and focused on the maintenance of biodiversity and the remotion of pollutants.^[19]
Brown biotechnology is related to the management of arid lands and deserts. One application is the creation of enhanced seeds that resist extreme environmental conditions of arid regions, which is related to the innovation, creation of agriculture techniques and management of resources.^[19]
Violet biotechnology is related to law, ethical and philosophical issues around biotechnology.^[19]
Dark biotechnology is the color associated with bioterrorism or biological weapons and biowarfare which uses microorganisms, and toxins to cause diseases and death in humans, livestock and crops.^[25]^[19]

Medicine

In medicine, modern biotechnology has many applications in areas such as pharmaceutical drug discoveries and production, pharmacogenomics, and genetic testing (or genetic screening).

DNA microarray chip – some can do as many as a million blood tests at once

Pharmacogenomics (a combination of pharmacology and genomics) is the technology that analyses how genetic makeup affects an individual's response to drugs.^[26] It deals with the influence of genetic variation on drug responses in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity.^[27] By doing so, pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects.^[28] Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.^[29]^[30]

Computer-generated image of insulin hexamers highlighting the threefold symmetry, the zinc ions holding it together, and the histidine residues involved in zinc binding.

Biotechnology has contributed to the discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology – biopharmaceutics. Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with a plasmid vector inserted into the bacterium Escherichia coli. Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle or pigs). The resulting genetically engineered bacterium enabled the production of vast quantities of synthetic human insulin at relatively low cost.^[31]^[32] Biotechnology has also enabled emerging therapeutics like gene therapy. The application of biotechnology to basic science (for example through the Human Genome Project) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well.^[32]

Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases, and can also be used to determine a child's parentage (genetic mother and father) or in general a person's ancestry. In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes, genes, or proteins.^[33] Most of the time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder. As of 2011 several hundred genetic tests were in use.^[34]^[35] Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling.

Agriculture

Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture, the DNA of which has been modified with genetic engineering techniques. In most cases, the main aim is to introduce a new trait that does not occur naturally in the species.

Examples in food crops include resistance to certain pests,^[36] diseases,^[37] stressful environmental conditions,^[38] resistance to chemical treatments (e.g. resistance to a herbicide^[39]), reduction of spoilage,^[40] or improving the nutrient profile of the crop.^[41] Examples in non-food crops include production of pharmaceutical agents,^[42] biofuels,^[43] and other industrially useful goods,^[44] as well as for bioremediation.^[45]^[46]

Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 square kilometers (4,200,000 acres) to 1,600,000 km² (395 million acres).^[47] 10% of the world's crop lands were planted with GM crops in 2010.^[47] As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the USA, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.^[47]

Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with the methods of genetic engineering. These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding.^[48] Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato.^[49] To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean, corn, canola, and cotton seed oil. These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on the market,^[50] but in 2015 the FDA approved the first GM salmon for commercial production and consumption.^[51]

There is a scientific consensus^[52]^[53]^[54]^[55]^[56]^[57]^[58] that currently available food derived from GM crops poses no greater risk to human health than conventional food,^[59]^[60]^[61]^[62]^[63]^[64]^[65] but that each GM food must be tested on a case-by-case basis before introduction.^[66]^[67]^[68] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.^[69]^[70]^[71]^[72] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.^[73]^[74]^[75]^[76]

GM crops also provide a number of ecological benefits, if not used in excess.^[77] However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by the fact these organisms are subject to intellectual property law.

Industrial

Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation. It includes the practice of using cells such as micro-organisms, or components of cells like enzymes, to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels.^[78] In the current decades, significant progress has been done in creating genetically modified organisms (GMOs) that enhance the diversity of applications and economical viability of industrial biotechnology. By using renewable raw materials to produce a variety of chemicals and fuels, industrial biotechnology is actively advancing towards lowering greenhouse gas emissions and moving away from a petrochemical-based economy.^[79]

Environmental

The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that the difference between beneficial biotechnology (e.g.bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g. flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively.^[80] Cleaning up environmental wastes is an example of an application of environmental biotechnology; whereas loss of biodiversity or loss of containment of a harmful microbe are examples of environmental implications of biotechnology.

Regulation

The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish. There are differences in the regulation of GMOs between countries, with some of the most marked differences occurring between the USA and Europe.^[81] Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.^[82] The European Union differentiates between approval for cultivation within the EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing.^[83] The cultivation of GMOs has triggered a debate about coexistence of GM and non GM crops. Depending on the coexistence regulations, incentives for cultivation of GM crops differ.^[84]

Learning

In 1988, after prompting from the United States Congress, the National Institute of General Medical Sciences (National Institutes of Health) (NIGMS) instituted a funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support is provided for two or three years during the course of their Ph.D. thesis work. Nineteen institutions offer NIGMS supported BTPs.^[85] Biotechnology training is also offered at the undergraduate level and in community colleges.

References and notes

^ Text of the CBD. CBD.int. Retrieved on March 20, 2013.
^ ^a ^b "Incorporating Biotechnology into the Classroom What is Biotechnology?", from the curricula of the 'Incorporating Biotechnology into the High School Classroom through Arizona State University's BioREACH program', accessed on October 16, 2012). Public.asu.edu. Retrieved on March 20, 2013.
^ Biotechnology Archived November 7, 2012, at the Wayback Machine.. Portal.acs.org. Retrieved on March 20, 2013.
^ "Archived copy" (PDF). Archived from the original (PDF) on August 7, 2015. Retrieved December 29, 2014.
^ What is biotechnology?. Europabio. Retrieved on March 20, 2013.
^ KEY BIOTECHNOLOGY INDICATORS (December 2011). oecd.org
^ Biotechnology policies – Organization for Economic Co-operation and Development. Oecd.org. Retrieved on March 20, 2013.
^ "History, scope and development of biotechnology - Book chapter - IOPscience". iopscience.iop.org. Retrieved 2018-10-30.
^ What Is Bioengineering? Archived January 23, 2013, at the Wayback Machine.. Bionewsonline.com. Retrieved on March 20, 2013.
^ See Arnold JP (2005). Origin and History of Beer and Brewing: From Prehistoric Times to the Beginning of Brewing Science and Technology. Cleveland, Ohio: BeerBooks. p. 34. ISBN 978-0-9662084-1-2. OCLC 71834130..
^ Cole-Turner R (2003). "Biotechnology". Encyclopedia of Science and Religion. Retrieved December 7, 2014.
^ ^a ^b Thieman WJ, Palladino MA (2008). Introduction to Biotechnology. Pearson/Benjamin Cummings. ISBN 978-0-321-49145-9.
^ Springham D, Springham G, Moses V, Cape RE (August 24, 1999). Biotechnology: The Science and the Business. CRC Press. p. 1. ISBN 978-90-5702-407-8.
^ "Diamond v. Chakrabarty, 447 U.S. 303 (1980). No. 79-139." United States Supreme Court. June 16, 1980. Retrieved on May 4, 2007.
^ VoIP Providers And Corn Farmers Can Expect To Have Bumper Years In 2008 And Beyond, According To The Latest Research Released By Business Information Analysts At IBISWorld. Los Angeles (March 19, 2008)
^ The Recession List — Top 10 Industries to Fly and Fl... (ith anincreasing share accounted for by ...), bio-medicine.org
^ Gerstein, M. "Bioinformatics Introduction Archived 2007-06-16 at the Wayback Machine.." Yale University. Retrieved on May 8, 2007.
^ Siam, R. (2009). Biotechnology Research and Development in Academia: providing the foundation for Egypt's Biotechnology spectrum of colors. Sixteenth Annual American University in Cairo Research Conference, American University in Cairo, Cairo, Egypt. BMC Proceedings, 31-5.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Kafarski, P. (2012). Rainbow Code of Biotechnology. CHEMIK. Wroclaw University
^ Biotech: true colours. (2009). TCE: The Chemical Engineer, (816), 26-31.
^ Aldridge, S. (2009). The four colours of biotechnology: the biotechnology sector is occasionally described as a rainbow, with each sub sector having its own colour. But what do the different colours of biotechnology have to offer the pharmaceutical industry?. Pharmaceutical Technology Europe, (1). 12.
^ Frazzetto G (September 2003). "White biotechnology". EMBO Reports. 4 (9): 835–7. doi:10.1038/sj.embor.embor928. PMC 1326365. PMID 12949582.
^ Frazzetto, G. (2003). White biotechnology. 21/03/2017, de EMBOpress Sitio
^ Advances in Biochemical Engineering/Biotechnology, Volume 135 2013, Yellow Biotechnology I
^ Edgar J, D. (2004). The Colours of Biotechnology: Science, Development and Humankind. Electronic Journal of Biotechnology, (3), 01
^ Ermak G. (2013) Modern Science & Future Medicine (second edition)
^ Wang L (2010). "Pharmacogenomics: a systems approach". Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2 (1): 3–22. doi:10.1002/wsbm.42. PMC 3894835. PMID 20836007.
^ Becquemont L (June 2009). "Pharmacogenomics of adverse drug reactions: practical applications and perspectives". Pharmacogenomics. 10 (6): 961–9. doi:10.2217/pgs.09.37. PMID 19530963.
^ "Guidance for Industry Pharmacogenomic Data Submissions" (PDF). U.S. Food and Drug Administration. March 2005. Retrieved August 27, 2008.
^ Squassina A, Manchia M, Manolopoulos VG, Artac M, Lappa-Manakou C, Karkabouna S, Mitropoulos K, Del Zompo M, Patrinos GP (August 2010). "Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice". Pharmacogenomics. 11 (8): 1149–67. doi:10.2217/pgs.10.97. PMID 20712531.
^ Bains W (1987). Genetic Engineering For Almost Everybody: What Does It Do? What Will It Do?. Penguin. p. 99. ISBN 978-0-14-013501-5.
^ ^a ^b U.S. Department of State International Information Programs, "Frequently Asked Questions About Biotechnology", USIS Online; available from USinfo.state.gov Archived September 12, 2007, at the Wayback Machine., accessed September 13, 2007. Cf. Feldbaum C (February 2002). "Biotechnology. Some history should be repeated". Science. 295 (5557): 975. doi:10.1126/science.1069614. PMID 11834802.
^ "What is genetic testing? – Genetics Home Reference". Ghr.nlm.nih.gov. May 30, 2011. Retrieved June 7, 2011.
^ "Genetic Testing: MedlinePlus". Nlm.nih.gov. Retrieved June 7, 2011.
^ "Definitions of Genetic Testing". Definitions of Genetic Testing (Jorge Sequeiros and Bárbara Guimarães). EuroGentest Network of Excellence Project. September 11, 2008. Archived from the original on February 4, 2009. Retrieved August 10, 2008.
^ Genetically Altered Potato Ok'd For Crops Lawrence Journal-World – May 6, 1995
^ National Academy of Sciences (2001). Transgenic Plants and World Agriculture. Washington: National Academy Press.
^ Paarlburg R (January 2011). "Drought Tolerant GMO Maize in Africa, Anticipating Regulatory Hurdles" (PDF). International Life Sciences Institute. Archived from the original (PDF) on December 22, 2014. Retrieved April 25, 2011.
^ Carpenter J. & Gianessi L. (1999). Herbicide tolerant soybeans: Why growers are adopting Roundup Ready varieties. AgBioForum, 2(2), 65–72.
^ Haroldsen VM, Paulino G, Chi-ham C, Bennett AB (2012). "Research and adoption of biotechnology strategies could improve California fruit and nut crops" (PDF). California Agriculture. 66 (2): 62–69. doi:10.3733/ca.v066n02p62. Archived from the original (PDF) on May 11, 2013.
^ About Golden Rice Archived November 2, 2012, at the Wayback Machine.. Irri.org. Retrieved on March 20, 2013.
^ Gali Weinreb and Koby Yeshayahou for Globes May 2, 2012. FDA approves Protalix Gaucher treatment Archived May 29, 2013, at the Wayback Machine.
^ Carrington, Damien (January 19, 2012) GM microbe breakthrough paves way for large-scale seaweed farming for biofuels The Guardian. Retrieved March 12, 2012
^ van Beilen JB, Poirier Y (May 2008). "Production of renewable polymers from crop plants". The Plant Journal. 54 (4): 684–701. doi:10.1111/j.1365-313X.2008.03431.x. PMID 18476872.
^ Strange, Amy (September 20, 2011) Scientists engineer plants to eat toxic pollution The Irish Times. Retrieved September 20, 2011
^ Diaz E (editor). (2008). Microbial Biodegradation: Genomics and Molecular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-17-2.
^ ^a ^b ^c James C (2011). "ISAAA Brief 43, Global Status of Commercialized Biotech/GM Crops: 2011". ISAAA Briefs. Ithaca, New York: International Service for the Acquisition of Agri-biotech Applications (ISAAA). Retrieved June 2, 2012.
^ GM Science Review First Report Archived October 16, 2013, at the Wayback Machine., Prepared by the UK GM Science Review panel (July 2003). Chairman Professor Sir David King, Chief Scientific Advisor to the UK Government, P 9
^ James C (1996). "Global Review of the Field Testing and Commercialization of Transgenic Plants: 1986 to 1995" (PDF). The International Service for the Acquisition of Agri-biotech Applications. Retrieved July 17, 2010.
^ "Consumer Q&A". Fda.gov. March 6, 2009. Retrieved December 29, 2012.
^ "AquAdvantage Salmon". FDA. Retrieved July 20, 2018.
^ Nicolia A, Manzo A, Veronesi F, Rosellini D (March 2014). "An overview of the last 10 years of genetically engineered crop safety research" (PDF). Critical Reviews in Biotechnology. 34 (1): 77–88. doi:10.3109/07388551.2013.823595. PMID 24041244.
^ "State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops". Food and Agriculture Organization of the United Nations. Retrieved February 8, 2016.
^ Ronald P (May 2011). "Plant genetics, sustainable agriculture and global food security". Genetics. 188 (1): 11–20. doi:10.1534/genetics.111.128553. PMC 3120150. PMID 21546547.
^ Domingo JL, Giné Bordonaba J (May 2011). "A literature review on the safety assessment of genetically modified plants". Environment International. 37 (4): 734–42. doi:10.1016/j.envint.2011.01.003. PMID 21296423.
^ Krimsky S (2015). "An Illusory Consensus behind GMO Health Assessment" (PDF). Science, Technology, & Human Values. 40 (6): 1–32. doi:10.1177/0162243915598381. I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.
^ Panchin AY, Tuzhikov AI (March 2017). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology. 37 (2): 213–217. doi:10.3109/07388551.2015.1130684. PMID 26767435.
^ Yang YT, Chen B (April 2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96 (6): 1851–5. doi:10.1002/jsfa.7523. PMID 26536836.
^ "Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods" (PDF). American Association for the Advancement of Science. October 20, 2012. Retrieved February 8, 2016.
^ Pinholster G (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. Retrieved February 8, 2016.
^ A decade of EU-funded GMO research (2001–2010) (PDF). Directorate-General for Research and Innovation. Biotechnologies, Agriculture, Food. European Commission, European Union. 2010. doi:10.2777/97784. ISBN 978-92-79-16344-9. Retrieved February 8, 2016.
^ "AMA Report on Genetically Modified Crops and Foods (online summary)". American Medical Association. January 2001. Retrieved March 19, 2016.
^ "REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods" (PDF). American Medical Association. 2012. Archived from the original on September 7, 2012. Retrieved March 19, 2016.
^ "Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion". Library of Congress. June 9, 2015. Retrieved February 8, 2016.
^ "Genetically Engineered Crops: Experiences and Prospects". The National Academies of Sciences, Engineering, and Medicine (US). 2016. p. 149. Retrieved May 19, 2016.
^ "Frequently asked questions on genetically modified foods". World Health Organization. Retrieved February 8, 2016.
^ Haslberger AG (July 2003). "Codex guidelines for GM foods include the analysis of unintended effects". Nature Biotechnology. 21 (7): 739–41. doi:10.1038/nbt0703-739. PMID 12833088.
^ Some medical organizations, including the British Medical Association, advocate further caution based upon the precautionary principle:
"Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved March 21, 2016.
^ Funk C, Rainie L (January 29, 2015). "Public and Scientists' Views on Science and Society". Pew Research Center. Retrieved February 24, 2016. The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods. Nearly nine-in-ten (88%) scientists say it is generally safe to eat GM foods compared with 37% of the general public, a difference of 51 percentage points.
^ Marris C (July 2001). "Public views on GMOs: deconstructing the myths. Stakeholders in the GMO debate often describe public opinion as irrational. But do they really understand the public?". EMBO Reports. 2 (7): 545–8. doi:10.1093/embo-reports/kve142. PMC 1083956. PMID 11463731.
^ Final Report of the PABE research project (December 2001). "Public Perceptions of Agricultural Biotechnologies in Europe". Commission of European Communities. Retrieved February 24, 2016.
^ Scott SE, Inbar Y, Rozin P (May 2016). "Evidence for Absolute Moral Opposition to Genetically Modified Food in the United States" (PDF). Perspectives on Psychological Science. 11 (3): 315–24. doi:10.1177/1745691615621275. PMID 27217243.
^ "Restrictions on Genetically Modified Organisms". Library of Congress. June 9, 2015. Retrieved February 24, 2016.
^ Bashshur R (February 2013). "FDA and Regulation of GMOs". American Bar Association. Retrieved February 24, 2016.
^ Sifferlin A (October 3, 2015). "Over Half of E.U. Countries Are Opting Out of GMOs". Time.
^ Lynch D, Vogel D (April 5, 2001). "The Regulation of GMOs in Europe and the United States: A Case-Study of Contemporary European Regulatory Politics". Council on Foreign Relations. Retrieved February 24, 2016.
^ Pollack A (April 13, 2010). "Study Says Overuse Threatens Gains From Modified Crops". New York Times.
^ Industrial Biotechnology and Biomass Utilisation Archived April 5, 2013, at the Wayback Machine.
^ Industrial biotechnology, A powerful, innovative technology to mitigate climate change
^ Daniel A. Vallero, Environmental Biotechnology: A Biosystems Approach, Academic Press, Amsterdam, NV; ISBN 978-0-12-375089-1; 2010.
^ Gaskell G, Bauer MW, Durant J, Allum NC (July 1999). "Worlds apart? The reception of genetically modified foods in Europe and the U.S". Science. 285 (5426): 384–7. doi:10.1126/science.285.5426.384. PMID 10411496.
^ "The History and Future of GM Potatoes". Potato Pro. March 10, 2010.
^ Wesseler J, Kalaitzandonakes N (2011). "Present and Future EU GMO policy". In Oskam A, Meesters G, Silvis H. EU Policy for Agriculture, Food and Rural Areas (2nd ed.). Wageningen: Wageningen Academic Publishers. pp. 23–332.
^ Beckmann VC, Soregaroli J, Wesseler J (2011). "Coexistence of genetically modified (GM) and non-modified (non GM) crops: Are the two main property rights regimes equivalent with respect to the coexistence value?". In Carter C, Moschini G, Sheldon I. Genetically modified food and global welfare. Frontiers of Economics and Globalization Series. 10. Bingley, UK: Emerald Group Publishing. pp. 201–224.
^ "Biotechnology Predoctoral Training Program". National Institute of General Medical Sciences. December 18, 2013. Retrieved October 28, 2014.

External links

Media related to Biotechnology at Wikimedia Commons
Foundation for Biotechnology Awareness and Education,
A report on Agricultural Biotechnology focusing on the impacts of "Green" Biotechnology with a special emphasis on economic aspects. fao.org.
US Economic Benefits of Biotechnology to Business and Society NOAA Economics, economics.noaa.gov
Database of the Safety and Benefits of Biotechnology – a database of peer-reviewed scientific papers and the safety and benefits of biotechnology.
What is Biotechnology? – A curated collection of resources about the people, places and technologies that have enabled biotechnology to transform the world we live in today

English Journal

Stress Responses in Probiotic Lactobacillus casei.

Hosseini Nezhad M1, Hussain MA, Britz ML.
Critical reviews in food science and nutrition.Crit Rev Food Sci Nutr.2015 May 12;55(6):740-9. doi: 10.1080/10408398.2012.675601.
Survival in harsh environments is critical to both the industrial performance of lactic acid bacteria (LAB) and their competitiveness in complex microbial ecologies. Among the LAB, members of the Lactobacillus casei group have industrial applications as acid-producing starter cultures for milk ferme
PMID 24915363

Determination of free diferulic, disinapic and dicoumaric acids in plants and foods.

Grúz J1, Pospíšil J2, Kozubíková H3, Pospíšil T3, Doležal K2, Bunzel M4, Strnad M2.
Food chemistry.Food Chem.2015 Mar 15;171:280-6. doi: 10.1016/j.foodchem.2014.08.131. Epub 2014 Sep 8.
Hydroxycinnamates are common phenolic compounds of plants and plant foods, often found in substantial quantities. Due to their high in vitro antioxidant activity they can easily be oxidized under oxidative conditions. In this study, we found that in vitro oxidation of coumaric, ferulic and sinapic a
PMID 25308670

Effect of commercial cellulases and refining on kraft pulp properties: Correlations between treatment impacts and enzymatic activity components.

Cui L1, Meddeb-Mouelhi F2, Laframboise F1, Beauregard M3.
Carbohydrate polymers.Carbohydr Polym.2015 Jan 22;115:193-9. doi: 10.1016/j.carbpol.2014.08.076. Epub 2014 Sep 2.
The importance of enzymes as biotechnological catalysts for paper industry is now recognized. In this study, five cellulase formulations were used for fibre modification. The number of PFI revolutions decreased by about 50% while achieving the same freeness value (decrease in CSF by 200mL) with the
PMID 25439885

Japanese Journal

Lignin polymerization: how do plants manage the chemistry so well?

Tobimatsu Yuki,Schuetz Mathias
Current Opinion in Biotechnology (56), 75-81, 2019-04
… Further advancement in this research area will continue to increase our capacity to manipulate lignin content/structure in biomass to meet our own biotechnological purposes. …
NAID 120006534615

Comparative transcriptome analysis revealed the improved β-carotene production in Sporidiobolus pararoseus yellow mutant MuY9

Li Chunji,Li Bingxue,Zhang Ning,Wang Qifan,Wang Wenjing,Zou Hongtao
The Journal of General and Applied Microbiology 65(3), 121-128, 2019
… These structurally diverse pigments have received considerable attention due to their biotechnological applications and potential beneficial effects on human health. …
NAID 130007680242

Isolation, purification and characterization of an extracellular L-asparaginase produced by a newly isolated Bacillus megaterium strain MG1 from the water bodies of Moraghat forest, Jalpaiguri, India

Pal Roy Moushree,Das Vaskar,Patra Amal
The Journal of General and Applied Microbiology 65(3), 137-144, 2019
… Its marked stability and activity in organic solvents and reducing agents suggest that this asparaginase is highly suitable as a biotechnological tool with industrial applications. …
NAID 130007680239

「biotech」

　　[★]

生物工学、生命工学、バイオテクノロジー

関: bioengineering、biotechnological、biotechnology

「生物工学的」

　　[★]

英: biotechnological
関: 生物工学、バイオテクノロジー

「bioengineering」

　　[★]

生物工学

関: biotech、biotechnological、biotechnology

[1] Text of the CBD. CBD.int. Retrieved on March 20, 2013.

[BioREACH-2] "Incorporating Biotechnology into the Classroom What is Biotechnology?", from the curricula of the 'Incorporating Biotechnology into the High School Classroom through Arizona State University's BioREACH program', accessed on October 16, 2012). Public.asu.edu. Retrieved on March 20, 2013.

[3] Biotechnology Archived November 7, 2012, at the Wayback Machine.. Portal.acs.org. Retrieved on March 20, 2013.

[4] "Archived copy" (PDF). Archived from the original (PDF) on August 7, 2015. Retrieved December 29, 2014.

[5] What is biotechnology?. Europabio. Retrieved on March 20, 2013.

[6] KEY BIOTECHNOLOGY INDICATORS (December 2011). oecd.org

[7] Biotechnology policies – Organization for Economic Co-operation and Development. Oecd.org. Retrieved on March 20, 2013.

[8] "History, scope and development of biotechnology - Book chapter - IOPscience". iopscience.iop.org. Retrieved 2018-10-30.

[9] What Is Bioengineering? Archived January 23, 2013, at the Wayback Machine.. Bionewsonline.com. Retrieved on March 20, 2013.

[10] See Arnold JP (2005). Origin and History of Beer and Brewing: From Prehistoric Times to the Beginning of Brewing Science and Technology. Cleveland, Ohio: BeerBooks. p. 34. ISBN 978-0-9662084-1-2. OCLC 71834130..

[11] Cole-Turner R (2003). "Biotechnology". Encyclopedia of Science and Religion. Retrieved December 7, 2014.

[Thieman-12] Thieman WJ, Palladino MA (2008). Introduction to Biotechnology. Pearson/Benjamin Cummings. ISBN 978-0-321-49145-9.

[Springham_biotechnology-13] Springham D, Springham G, Moses V, Cape RE (August 24, 1999). Biotechnology: The Science and the Business. CRC Press. p. 1. ISBN 978-90-5702-407-8.

[DiamondvChakrabarty-14] "Diamond v. Chakrabarty, 447 U.S. 303 (1980). No. 79-139." United States Supreme Court. June 16, 1980. Retrieved on May 4, 2007.

[15] VoIP Providers And Corn Farmers Can Expect To Have Bumper Years In 2008 And Beyond, According To The Latest Research Released By Business Information Analysts At IBISWorld. Los Angeles (March 19, 2008)

[16] The Recession List — Top 10 Industries to Fly and Fl... (ith anincreasing share accounted for by ...), bio-medicine.org

[gerstein-17] Gerstein, M. "Bioinformatics Introduction Archived 2007-06-16 at the Wayback Machine.." Yale University. Retrieved on May 8, 2007.

[:2-18] Siam, R. (2009). Biotechnology Research and Development in Academia: providing the foundation for Egypt's Biotechnology spectrum of colors. Sixteenth Annual American University in Cairo Research Conference, American University in Cairo, Cairo, Egypt. BMC Proceedings, 31-5.

[:0-19] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Kafarski, P. (2012). Rainbow Code of Biotechnology. CHEMIK. Wroclaw University

[:1-20] Biotech: true colours. (2009). TCE: The Chemical Engineer, (816), 26-31.

[21] Aldridge, S. (2009). The four colours of biotechnology: the biotechnology sector is occasionally described as a rainbow, with each sub sector having its own colour. But what do the different colours of biotechnology have to offer the pharmaceutical industry?. Pharmaceutical Technology Europe, (1). 12.

[22] Frazzetto G (September 2003). "White biotechnology". EMBO Reports. 4 (9): 835–7. doi:10.1038/sj.embor.embor928. PMC 1326365. PMID 12949582.

[:4-23] Frazzetto, G. (2003). White biotechnology. 21/03/2017, de EMBOpress Sitio

[:6-24] Advances in Biochemical Engineering/Biotechnology, Volume 135 2013, Yellow Biotechnology I

[25] Edgar J, D. (2004). The Colours of Biotechnology: Science, Development and Humankind. Electronic Journal of Biotechnology, (3), 01

[26] Ermak G. (2013) Modern Science & Future Medicine (second edition)

[pmid20836007-27] Wang L (2010). "Pharmacogenomics: a systems approach". Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2 (1): 3–22. doi:10.1002/wsbm.42. PMC 3894835. PMID 20836007.

[pmid19530963-28] Becquemont L (June 2009). "Pharmacogenomics of adverse drug reactions: practical applications and perspectives". Pharmacogenomics. 10 (6): 961–9. doi:10.2217/pgs.09.37. PMID 19530963.

[29] "Guidance for Industry Pharmacogenomic Data Submissions" (PDF). U.S. Food and Drug Administration. March 2005. Retrieved August 27, 2008.

[pmid20712531-30] Squassina A, Manchia M, Manolopoulos VG, Artac M, Lappa-Manakou C, Karkabouna S, Mitropoulos K, Del Zompo M, Patrinos GP (August 2010). "Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice". Pharmacogenomics. 11 (8): 1149–67. doi:10.2217/pgs.10.97. PMID 20712531.

[31] Bains W (1987). Genetic Engineering For Almost Everybody: What Does It Do? What Will It Do?. Penguin. p. 99. ISBN 978-0-14-013501-5.

[USIS-32] U.S. Department of State International Information Programs, "Frequently Asked Questions About Biotechnology", USIS Online; available from USinfo.state.gov Archived September 12, 2007, at the Wayback Machine., accessed September 13, 2007. Cf. Feldbaum C (February 2002). "Biotechnology. Some history should be repeated". Science. 295 (5557): 975. doi:10.1126/science.1069614. PMID 11834802.

[33] "What is genetic testing? – Genetics Home Reference". Ghr.nlm.nih.gov. May 30, 2011. Retrieved June 7, 2011.

[34] "Genetic Testing: MedlinePlus". Nlm.nih.gov. Retrieved June 7, 2011.

[35] "Definitions of Genetic Testing". Definitions of Genetic Testing (Jorge Sequeiros and Bárbara Guimarães). EuroGentest Network of Excellence Project. September 11, 2008. Archived from the original on February 4, 2009. Retrieved August 10, 2008.

[news.google.co.uk-36] Genetically Altered Potato Ok'd For Crops Lawrence Journal-World – May 6, 1995

[37] National Academy of Sciences (2001). Transgenic Plants and World Agriculture. Washington: National Academy Press.

[38] Paarlburg R (January 2011). "Drought Tolerant GMO Maize in Africa, Anticipating Regulatory Hurdles" (PDF). International Life Sciences Institute. Archived from the original (PDF) on December 22, 2014. Retrieved April 25, 2011.

[39] Carpenter J. & Gianessi L. (1999). Herbicide tolerant soybeans: Why growers are adopting Roundup Ready varieties. AgBioForum, 2(2), 65–72.

[Haroldsen1-40] Haroldsen VM, Paulino G, Chi-ham C, Bennett AB (2012). "Research and adoption of biotechnology strategies could improve California fruit and nut crops" (PDF). California Agriculture. 66 (2): 62–69. doi:10.3733/ca.v066n02p62. Archived from the original (PDF) on May 11, 2013.

[41] About Golden Rice Archived November 2, 2012, at the Wayback Machine.. Irri.org. Retrieved on March 20, 2013.

[42] Gali Weinreb and Koby Yeshayahou for Globes May 2, 2012. FDA approves Protalix Gaucher treatment Archived May 29, 2013, at the Wayback Machine.

[43] Carrington, Damien (January 19, 2012) GM microbe breakthrough paves way for large-scale seaweed farming for biofuels The Guardian. Retrieved March 12, 2012

[44] van Beilen JB, Poirier Y (May 2008). "Production of renewable polymers from crop plants". The Plant Journal. 54 (4): 684–701. doi:10.1111/j.1365-313X.2008.03431.x. PMID 18476872.

[45] Strange, Amy (September 20, 2011) Scientists engineer plants to eat toxic pollution The Irish Times. Retrieved September 20, 2011

[Diaz-46] Diaz E (editor). (2008). Microbial Biodegradation: Genomics and Molecular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-17-2.

[James2011-47] James C (2011). "ISAAA Brief 43, Global Status of Commercialized Biotech/GM Crops: 2011". ISAAA Briefs. Ithaca, New York: International Service for the Acquisition of Agri-biotech Applications (ISAAA). Retrieved June 2, 2012.

[48] GM Science Review First Report Archived October 16, 2013, at the Wayback Machine., Prepared by the UK GM Science Review panel (July 2003). Chairman Professor Sir David King, Chief Scientific Advisor to the UK Government, P 9

[James_1996-49] James C (1996). "Global Review of the Field Testing and Commercialization of Transgenic Plants: 1986 to 1995" (PDF). The International Service for the Acquisition of Agri-biotech Applications. Retrieved July 17, 2010.

[50] "Consumer Q&A". Fda.gov. March 6, 2009. Retrieved December 29, 2012.

[51] "AquAdvantage Salmon". FDA. Retrieved July 20, 2018.

[52] Nicolia A, Manzo A, Veronesi F, Rosellini D (March 2014). "An overview of the last 10 years of genetically engineered crop safety research" (PDF). Critical Reviews in Biotechnology. 34 (1): 77–88. doi:10.3109/07388551.2013.823595. PMID 24041244.

[53] "State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops". Food and Agriculture Organization of the United Nations. Retrieved February 8, 2016.

[54] Ronald P (May 2011). "Plant genetics, sustainable agriculture and global food security". Genetics. 188 (1): 11–20. doi:10.1534/genetics.111.128553. PMC 3120150. PMID 21546547.

[55] Domingo JL, Giné Bordonaba J (May 2011). "A literature review on the safety assessment of genetically modified plants". Environment International. 37 (4): 734–42. doi:10.1016/j.envint.2011.01.003. PMID 21296423.

[56] Krimsky S (2015). "An Illusory Consensus behind GMO Health Assessment" (PDF). Science, Technology, & Human Values. 40 (6): 1–32. doi:10.1177/0162243915598381. I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.

[57] Panchin AY, Tuzhikov AI (March 2017). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology. 37 (2): 213–217. doi:10.3109/07388551.2015.1130684. PMID 26767435.

[58] Yang YT, Chen B (April 2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture. 96 (6): 1851–5. doi:10.1002/jsfa.7523. PMID 26536836.

[59] "Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods" (PDF). American Association for the Advancement of Science. October 20, 2012. Retrieved February 8, 2016.

[60] Pinholster G (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. Retrieved February 8, 2016.

[61] A decade of EU-funded GMO research (2001–2010) (PDF). Directorate-General for Research and Innovation. Biotechnologies, Agriculture, Food. European Commission, European Union. 2010. doi:10.2777/97784. ISBN 978-92-79-16344-9. Retrieved February 8, 2016.

[62] "AMA Report on Genetically Modified Crops and Foods (online summary)". American Medical Association. January 2001. Retrieved March 19, 2016.

[63] "REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods" (PDF). American Medical Association. 2012. Archived from the original on September 7, 2012. Retrieved March 19, 2016.

[64] "Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion". Library of Congress. June 9, 2015. Retrieved February 8, 2016.

[65] "Genetically Engineered Crops: Experiences and Prospects". The National Academies of Sciences, Engineering, and Medicine (US). 2016. p. 149. Retrieved May 19, 2016.

[66] "Frequently asked questions on genetically modified foods". World Health Organization. Retrieved February 8, 2016.

[67] Haslberger AG (July 2003). "Codex guidelines for GM foods include the analysis of unintended effects". Nature Biotechnology. 21 (7): 739–41. doi:10.1038/nbt0703-739. PMID 12833088.

[68] Some medical organizations, including the British Medical Association, advocate further caution based upon the precautionary principle:
"Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved March 21, 2016.

[69] Funk C, Rainie L (January 29, 2015). "Public and Scientists' Views on Science and Society". Pew Research Center. Retrieved February 24, 2016. The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods. Nearly nine-in-ten (88%) scientists say it is generally safe to eat GM foods compared with 37% of the general public, a difference of 51 percentage points.

[70] Marris C (July 2001). "Public views on GMOs: deconstructing the myths. Stakeholders in the GMO debate often describe public opinion as irrational. But do they really understand the public?". EMBO Reports. 2 (7): 545–8. doi:10.1093/embo-reports/kve142. PMC 1083956. PMID 11463731.

[71] Final Report of the PABE research project (December 2001). "Public Perceptions of Agricultural Biotechnologies in Europe". Commission of European Communities. Retrieved February 24, 2016.

[72] Scott SE, Inbar Y, Rozin P (May 2016). "Evidence for Absolute Moral Opposition to Genetically Modified Food in the United States" (PDF). Perspectives on Psychological Science. 11 (3): 315–24. doi:10.1177/1745691615621275. PMID 27217243.

[73] "Restrictions on Genetically Modified Organisms". Library of Congress. June 9, 2015. Retrieved February 24, 2016.

[74] Bashshur R (February 2013). "FDA and Regulation of GMOs". American Bar Association. Retrieved February 24, 2016.

[75] Sifferlin A (October 3, 2015). "Over Half of E.U. Countries Are Opting Out of GMOs". Time.

[76] Lynch D, Vogel D (April 5, 2001). "The Regulation of GMOs in Europe and the United States: A Case-Study of Contemporary European Regulatory Politics". Council on Foreign Relations. Retrieved February 24, 2016.

[nytimes.com-77] Pollack A (April 13, 2010). "Study Says Overuse Threatens Gains From Modified Crops". New York Times.

[78] Industrial Biotechnology and Biomass Utilisation Archived April 5, 2013, at the Wayback Machine.

[79] Industrial biotechnology, A powerful, innovative technology to mitigate climate change

[80] Daniel A. Vallero, Environmental Biotechnology: A Biosystems Approach, Academic Press, Amsterdam, NV; ISBN 978-0-12-375089-1; 2010.

[81] Gaskell G, Bauer MW, Durant J, Allum NC (July 1999). "Worlds apart? The reception of genetically modified foods in Europe and the U.S". Science. 285 (5426): 384–7. doi:10.1126/science.285.5426.384. PMID 10411496.

[PotatoPro-82] "The History and Future of GM Potatoes". Potato Pro. March 10, 2010.

[Wesseler-2011-83] Wesseler J, Kalaitzandonakes N (2011). "Present and Future EU GMO policy". In Oskam A, Meesters G, Silvis H. EU Policy for Agriculture, Food and Rural Areas (2nd ed.). Wageningen: Wageningen Academic Publishers. pp. 23–332.

[Beckman-2011-84] Beckmann VC, Soregaroli J, Wesseler J (2011). "Coexistence of genetically modified (GM) and non-modified (non GM) crops: Are the two main property rights regimes equivalent with respect to the coexistence value?". In Carter C, Moschini G, Sheldon I. Genetically modified food and global welfare. Frontiers of Economics and Globalization Series. 10. Bingley, UK: Emerald Group Publishing. pp. 201–224.

[85] "Biotechnology Predoctoral Training Program". National Institute of General Medical Sciences. December 18, 2013. Retrieved October 28, 2014.

v t e Topics related to biology
People and history	Biologist Notable biologists History of biology Nobel Prize in Physiology or Medicine Timeline of biology and organic chemistry List of geneticists and biochemists
Institutions, publications	Bachelor of Science Publications
Terms and phrases	Omne vivum ex ovo In vivo In vitro In utero In silico
Related disciplines	Medicine (Physician) Physical anthropology Environmental science Life Sciences Biotechnology
Other	List of conservation topics Altricial and Precocial development strategies

匿名

検索

案内

案内

biotechnological