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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/15 21:49:06」(JST)

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Binaltorphimine (BNI) is a selective antagonist of the κ-opioid receptor (KOR).^[1] BNI and norbinaltorphimine (nor-BNI) were the first highly selective KOR antagonists to be discovered.^[1]

References

^ ^a ^b Portoghese PS, Lipkowski AW, Takemori AE (March 1987). "Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists". Life Sci. 40 (13): 1287–92. doi:10.1016/0024-3205(87)90585-6. PMID 2882399.

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English Journal

Antihyperalgesic effect of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO/cGMP/KATP pathway and κ-opioid receptor.

Gonçalves GM1, Capim SL, Vasconcellos ML, Marinho BG.
Behavioural pharmacology.Behav Pharmacol.2016 Mar 31. [Epub ahead of print]
The present study used behavioral analyses to investigate the involvement of the NO/cGMP/KATP pathway, serotoninergic, and opioid systems in the antinociceptive action of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol (CTHP) in mice. Oral administration of CTHP (1,
PMID 27035064

Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance.

Wang ZL1, Li N1, Wang P1, Tang HH1, Han ZL1, Song JJ1, Li XH1, Yu HP1, Zhang T1, Zhang R1, Xu B1, Zhang MN1, Fang Q2, Wang R3.
Neuropharmacology.Neuropharmacology.2016 Mar 9. pii: S0028-3908(16)30089-2. doi: 10.1016/j.neuropharm.2016.03.017. [Epub ahead of print]
Mounting evidences indicate the functional interactions between neuropeptide FF (NPFF) and opioids, including the endogenous opioids. In the present work, EN-9, a chimeric peptide containing the functional domains of the endogenous opioid endomorphin-2 (EM-2) and NPFF, was synthesized and pharmacolo
PMID 26970017

Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys.

Hutsell BA1, Cheng K2, Rice KC2, Negus SS1,3, Banks ML1,3.
Addiction biology.Addict Biol.2016 Mar;21(2):360-73. doi: 10.1111/adb.12206. Epub 2015 Jan 8.
The dynorphin/kappa opioid receptor (KOR) system has been implicated as one potential neurobiological modulator of the abuse-related effects of cocaine and as a potential target for medications development. This study determined effects of the KOR antagonist nor-binaltorphimine (nor-BNI) on cocaine
PMID 25581305

Japanese Journal

生体内在性オピオイドの性質と機能的役割

YAKUGAKU ZASSHI 136(4), 591-605, 2016
NAID 130005140772

Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice

Biological and Pharmaceutical Bulletin 37(8), 1269-1273, 2014
NAID 130004677531

Dynorphin-Kappa Opioid Receptor Signaling Partly Mediates Estrogen Negative Feedback Effect on LH Pulses in Female Rats

The Journal of reproduction and development 59(3), 266-272, 2013-06-01
NAID 10031184756

★リンクテーブル★

拡張検索	「norbinaltorphimine」「nor-binaltorphimine」

「norbinaltorphimine」

Binaltorphimine
Systematic (IUPAC) name
	(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-22-methyl-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.018,37.030,36]heptatriaconta-4(23),5(21),14(37),15,17,26(36),27,29-octaene-2,7,17,27-tetrol
Identifiers
CAS Number	105618-27-7
ATC code	None
PubChem	CID 5484197
ChemSpider	4588407
Chemical data
Formula	C41H45N3O6
Molar mass	675.813 g/mol
	SMILES O[C@@]57Cc1c%11c(n(c1[C@@H]6Oc2c4c(ccc2O)C[C@H]7N(CC3CC3)CC[C@@]456)C)[C@@H]%12Oc8c9c(ccc8O)C[C@H]%10N(CC[C@]9%12[C@@]%10(O)C%11)CC%13CC%13 ;
	InChI InChI=1S/C41H45N3O6/c1-42-32-24(16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,36(32)49-34)10-12-43(28)18-20-2-3-20)25-17-41(48)29-15-23-7-9-27(46)35-31(23)39(41,37(50-35)33(25)42)11-13-44(29)19-21-4-5-21/h6-9,20-21,28-29,36-37,45-48H,2-5,10-19H2,1H3/t28-,29+,36-,37-,38-,39-,40+,41+/m0/s1 ; Key:DKIVQMBUHVYDFC-KMALJSJFSA-N ;