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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/08 06:38:21」(JST)
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Bifemelane
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Systematic (IUPAC) name |
N-methyl-4-[2-(phenylmethyl)phenoxy]butan-1-amine |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
?
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Identifiers |
CAS number |
90293-01-9 Y |
ATC code |
N06AX08 |
PubChem |
CID 2377 |
ChemSpider |
2286 Y |
UNII |
Z4501GN13G Y |
ChEMBL |
CHEMBL1192517 N |
Chemical data |
Formula |
C18H23NO |
Molecular mass |
269.381 g/mol |
SMILES
- O(c1ccccc1Cc2ccccc2)CCCCNC
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InChI
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InChI=1S/C18H23NO/c1-19-13-7-8-14-20-18-12-6-5-11-17(18)15-16-9-3-2-4-10-16/h2-6,9-12,19H,7-8,13-15H2,1H3 Y
Key:QSQQPMHPCBLLGX-UHFFFAOYSA-N Y
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N (what is this?) (verify) |
Bifemelane (Alnert, Celeport) is a pharmaceutical drug used in the treatment of senile dementia in Japan.[1] It has nootropic, neuroprotective, and antidepressant effects, and acts through the cholinergic system in the brain.[2][3][4] Bifemelane is also useful for the treatment of glaucoma.[5]
See also
- Indeloxazine
- Teniloxazine
References
- ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 265. ISBN 0-412-46630-9.
- ^ Kondo, Y; Ogawa, N; Asanuma, M; Matsuura, K; Nishibayashi, K; Iwata, E (1996). "Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion". Neuroscience research 24 (4): 409–14. doi:10.1016/0168-0102(95)01017-3. PMID 8861111.
- ^ Egashira, T; Takayama, F; Yamanaka, Y (1996). "Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries". Japanese journal of pharmacology 72 (1): 57–65. doi:10.1254/jjp.72.57. PMID 8902600.
- ^ Moryl E, Danysz W, Quack G (June 1993). "Potential antidepressive properties of amantadine, memantine and bifemelane". Pharmacology & Toxicology 72 (6): 394–7. doi:10.1111/j.1600-0773.1993.tb01351.x. PMID 8361950.
- ^ Shigemitsu, T; Majima, Y (1996). "Use of bifemelane hydrochloride in improving and maintaining the visual field of patients with glaucoma". Clinical therapeutics 18 (1): 106–13. doi:10.1016/S0149-2918(96)80183-4. PMID 8851457.
Psychoanaleptics: Antidementia agents (N06D)
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Anticholinesterases |
- Cymserine
- Donepezil
- Galantamine
- Huperzine A (Huperzia serrata)
- Ladostigil
- Rivastigmine
- Stemazole
- Tacrine
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Others |
- Bifemelane
- Bilobalide (Ginkgo biloba)
- Cerlapirdine
- Ensaculin
- Latrepirdine
- Lecozotan
- Leteprinim
- Memantine
- Semagacestat
- Ergoloid
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Index of psychology and psychiatry
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Description |
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Disorders |
- Mental and behavioral
- Symptoms and signs
- Evaluation and testing
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Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
- psychostimulants, ADHD drugs and nootropics
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English Journal
- Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell.
- Yoshida Y1, Kumagai H, Ohkubo Y, Tsuchiya R, Morita M, Miyakawa H, Kudo Y.
- Journal of pharmacological sciences.J Pharmacol Sci.2006 Sep;102(1):121-8. Epub 2006 Sep 15.
- The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). Bifemelane (125 - 1,000 microM) induced a dose-dependent increase in the intracellular calcium concentration ([Ca(2+)](i)). In the highest concentration (1,000 microM), the drug caused
- PMID 16974067
- A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes.
- Yoshida Y1, Nakane A, Morita M, Kudo Y.
- Journal of pharmacological sciences.J Pharmacol Sci.2006 Feb;100(2):126-32. Epub 2006 Feb 11.
- We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. At concentrations of 10 - 30 microM, bifemelane induced a slow onset and small increase in the [Ca2+]i, while at higher concentrat
- PMID 16474207
- Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.
- Ogasawara T1, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K.
- Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.1999 Sep;64(1):41-52.
- The effects of (+)-5-oxo-D-prolinepiperidinamide monohydrate (NS-105) on the scopolamine-, electrolytic lesion of the nucleus basalis magnocellularis (NBM)-, AF64A-, baclofen-, cerebral ischemia- and electroconvulsive shock (ECS)-induced memory disruption in the passive avoidance response or radial
- PMID 10494996
Japanese Journal
- Effects of Bifemelane on the Calcium Level and ATP Release of the Human Origin Astrocyte Clonal Cell
- YOSHIDA Yoshitoku,KUMAGAI Haruno,OHKUBO Yoshiumi,TSUCHIYA Remi,MORITA Mitsuhiro,MIYAKAWA Hiroyoshi,KUDO Yoshihisa
- Journal of pharmacological sciences 102(1), 121-128, 2006-09-20
- … The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). … Bifemelane (125 – … Bifemelane caused a dose-dependent ATP release, but histamine and carbachol, which induced a large increase in [Ca2+]i, had no effects on the ATP release. …
- NAID 10020346475
- A Novel Effect of Bifemelane, a Nootropic Drug, on Intracellular Ca^<2+> Levels in Rat Cerebral Astrocytes
- YOSHIDA Yoshitoku,NAKANE Akira,MORITA Mitsuhiro,KUDO Yoshihisa
- Journal of pharmacological sciences 100(2), 126-132, 2006-02-20
- … We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. … 30 μM, bifemelane induced a slow onset and small increase in the [Ca2+]i, while at higher concentrations (100 – … When thapsigargin-treated astrocytes were returned to normal medium containing Ca2+ (1.8 mM), the [Ca2+]i increased significantly, and this effect was reversely inhibited by bifemelane. …
- NAID 10018240701
Related Links
- View and buy high purity Bifemelane hydrochloride from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... The technical data provided above is for guidance only. For batch specific data ...
- Nootropic Supplement & Smart Drug Reviews Home Popular Racetams Choline Natural Dopaminergics Nootropic Drugs Ampakines Branded Products Research Chemicals Russian Nootropics Review of Bifemelane November 14 ...
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