関: BADH

WordNet

any of a class of highly reactive chemical compounds; used in making resins and dyes and organic acids
a sweet tasting alkaloid that occurs in sugar beets

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アルデヒド(アルコールから抽出する有機化合物)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/01 20:27:26」(JST)

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In enzymology, a betaine-aldehyde dehydrogenase (EC 1.2.1.8) is an enzyme that catalyzes the chemical reaction

betaine aldehyde + NAD⁺ + H₂O betaine + NADH + 2 H⁺

The 3 substrates of this enzyme are betaine aldehyde, NAD⁺, and H₂O, whereas its 3 products are betaine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007^[update], 4 structures have been solved for this class of enzymes, with PDB accession codes 1A4S, 1BPW, 1WNB, and 1WND.

References

ROTHSCHILD HA, BARRON ES (1954). "The oxidation of betaine aldehyde by betaine aldehyde dehydrogenase". J. Biol. Chem. 209 (2): 511–23. PMID 13192104.
Tsutui N, Hirasawa E (2003). "Purification and properties of betaine aldehyde dehydrogenase from Avena sativa". J. Plant. Res. 116 (2): 133–40. doi:10.1007/s10265-003-0077-7. PMID 12736784.
L; González-Segura, L; Mújica-Jiménez, C; Contreras-Díaz, L (2003). "Ligand-induced conformational changes of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves affecting the reactivity of the catalytic thiol". Chem. Biol. Interact. 143-144: 129–37. doi:10.1016/S0009-2797(02)00197-7. PMID 12604197.
Eklund H; El-Ahmad, M; Ramaswamy, S; Hjelmqvist, L; Jörnvall, H; Eklund, H (1998). "Structure of betaine aldehyde dehydrogenase at 2.1 A resolution". Protein. Sci. 7 (10): 2106–17. doi:10.1002/pro.5560071007. PMC 2143847. PMID 9792097.
Takabe T; Tanaka, Y; Aoki, K; Hibino, T; Jikuya, H; Takano, J; Takabe, T; Takabe, T (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278 (7): 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265.

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English Journal

Aroma volatile analyses and 2AP characterization at various developmental stages in Basmati and Non-Basmati scented rice (Oryza sativa L.) cultivars.

Hinge VR1,2, Patil HB2, Nadaf AB3.
Rice (New York, N.Y.).Rice (N Y).2016 Dec;9(1):38. doi: 10.1186/s12284-016-0113-6. Epub 2016 Aug 5.
BACKGROUND: Rice plant growth is comprised of distinct phases, such as vegetative, reproductive, grain filling and maturity phases. In these phases synthesis and availability of primary and secondary metabolites including volatile organic compounds (VOC's) is highly variable. In scented rice, aroma
PMID 27495313

Dataset of liver proteins of eu- and hypothyroid rats affected in abundance by any of three factors: in vivo exposure to hexabromocyclododecane (HBCD), thyroid status, gender differences.

Miller I1, Renaut J2, Cambier S2, Murk AJ3, Gutleb AC2, Serchi T2.
Data in brief.Data Brief.2016 Aug 5;8:1344-7. doi: 10.1016/j.dib.2016.07.063. eCollection 2016.
Male Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days and obtained data compared with a previous study in females, "Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyr
PMID 27579339

Thirty-three years of 2-acetyl-1-pyrroline, a principal basmati aroma compound in scented rice (Oryza sativa L.): a status review.

Wakte K1, Zanan R1, Hinge V1, Khandagale K1, Nadaf A1, Henry R2.
Journal of the science of food and agriculture.J Sci Food Agric.2016 Jul 4. doi: 10.1002/jsfa.7875. [Epub ahead of print]
Rice is the staple food of around 3 billion people, most of them in Asia which accounts for 90% of global rice consumption. Aromatic rices have been preferred over non-aromatic rice for hundreds of years. They have a premium value in national as well as international market owing to their unique aro
PMID 27376959

Japanese Journal

Tissue Localization of the Glycine Betaine Biosynthetic Enzymes in Barley Leaves

Mitsuya Shiro,Kozaki Katsutoshi,Takabe Tetsuko
Plant Production Science 16(2), 117-122, 2013
… Barley (Hordeum vulgare L.) plants accumulate glycine betaine (GB), a major compatible solute, in response to salt stress. … In this study, we investigated the localization of two GB biosynthetic enzymes, choline monooxygenase (CMO) and betaine aldehyde dehydrogenase (BADH), in the tissues of barley plants (cv. …
NAID 130004850071

Production of transgenic Italian ryegrass expressing the betaine aldehyde dehydrogenase gene of zoysiagrass

Takahashi Wataru,Oishi Hideki,Ebina Masumi [他],KOMATSU Toshinori,TAKAMIZO Tadashi
Breeding science 60(3), 279-285, 2010-09-01
NAID 10030691272

イネのペルオキシソームにおけるベタインアルデヒド脱水素酵素の機能解析

三屋史朗,横田由香,藤原崇志,高倍鉄子
日本作物學會紀事 79, 298-299, 2010-03-30
NAID 10030133793

「ベタインアルデヒド脱水素酵素」

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PMC	articles
PubMed	articles
NCBI	proteins

betaine-aldehyde dehydrogenase
Identifiers
EC number	1.2.1.8
CAS number	9028-90-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins

　　[★]

英: betaine-aldehyde dehydrogenase、BADH
関: ベタインアルデヒドデヒドロゲナーゼ

「ベタインアルデヒドデヒドロゲナーゼ」

　　[★]

英: betaine-aldehyde dehydrogenase
関: ベタインアルデヒド脱水素酵素

「BADH」

　　[★]

ベタインアルデヒド脱水素酵素

関: betaine-aldehyde dehydrogenase

「aldehyde dehydrogenase」

　　[★] アルデヒドデヒドロゲナーゼ

同: ALDH

同: ALDH

同: ALDH

同: ACDH

「dehydrogenase」

　　[★] 脱水素酵素デヒドロゲナーゼ

「dehydrogenases」