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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/07 09:46:36」(JST)
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Bephenium
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| Systematic (IUPAC) name |
|
N-benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxynaphthalene-2-carboxylate
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| Clinical data |
Pregnancy
category |
|
Routes of
administration |
Oral |
| Pharmacokinetic data |
| Bioavailability |
<1% |
| Excretion |
Renal (negligible) |
| Identifiers |
| CAS Registry Number |
7181-73-9 N
3818-50-6 (hydroxynaphtoate) |
| ATC code |
P02CX02 |
| PubChem |
CID: 19667 |
| ChemSpider |
18524 Y |
| UNII |
47RU9546DX N |
| ChEMBL |
CHEMBL1673148 N |
| Chemical data |
| Formula |
C17H22NO+ |
| Molecular mass |
256.36 g/mol |
SMILES
-
O(c1ccccc1)CC[N+](Cc2ccccc2)(C)C
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InChI
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InChI=1S/C17H22NO/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17/h3-12H,13-15H2,1-2H3/q+1 N
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Key:AVWWVJUMXRXPNF-UHFFFAOYSA-N N
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| N (what is this?) (verify) |
Bephenium hydroxynaphthoate (INN, trade names Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex) is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.[1][2]
Bephenium is not FDA-approved and is not available in the United States.[3]
References
- ^ Sweetman S (ed.) (2009). Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press. p. 143. ISBN 978-0-85369-840-1.
- ^ Jayewardene G, Ismail MM, Wijayaratnam Y (July 1960). "Bephenium hydroxynaphthoate in treatment of ascariasis". Br Med J 2 (5194): 268–71. doi:10.1136/bmj.2.5194.268. PMC 2097409. PMID 14406934.
- ^ Pham PA (March 19, 2009). "Bephenium hydroxynaphthoate". Point-of-Care Information Technology ABX Guide. Johns Hopkins University. Retrieved on March 25, 2011. Freely available with registration.
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Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)
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| Antiplatyhelmintic agents |
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Antitrematodals
(schistosomicides)
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Binds tubulin
|
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AI
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Other/unknown
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- quinoline
- Praziquantel#
- Oxamniquine#
- phenol
- thiazole
- arylsulfonate
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|
|
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Anticestodals
(taeniacides)
|
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Binds tubulin
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Other/unknown
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- quinoline
- salicylanilide
- aminoacridine
- butyrophenone
- chlorophenol
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Antinematodal agents
(including
macrofilaricides) |
|
Binds tubulin
|
- benzimidazole
- Mebendazole#
- Albendazole#
- Tiabendazole
- Fenbendazole
- Ciclobendazole
- Flubendazole
|
|
|
Glutamate-gated chloride channel, GABA receptor
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- avermectins
- Abamectin
- Doramectin
- Emamectin
- Ivermectin#
- Selamectin
- milbemycins
- Moxidectin
- Milbemycin oxime
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|
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NMDA
|
|
|
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Other/unknown
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- piperazine
- Piperazine
- Diethylcarbamazine#
- thiazole
- quinolinium
- benzylammonium
- naphthalenesulfonate
- Tribendimidine
|
|
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of parasites and pests
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| Description |
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| Disease |
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| Treatment |
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English Journal
- [Morphological changes in the mucosa of the stomach and the small intestine of rats under the action of mebendazole].
- Blagov NA, Miagkova MA, Firsov VN, Zhuravleva TB, Petrova IV.AbstractThe effect of mebendazole on the gastric and intestinal mucosa was studied in 52 intact white rats. It was shown that the drug caused a significant damage to the mucosa, especially of goblet cells of villi and crypts and interfere with the mucoid secretion. The alterations after mebendazole administration were more severe than those caused by naphthamon. On the 13-15th day after the treatment the complete restoration of the damage was not seen.
- Meditsinskaia parazitologiia i parazitarnye bolezni.Med Parazitol (Mosk).1991 Sep-Oct;(5):41-4.
- The effect of mebendazole on the gastric and intestinal mucosa was studied in 52 intact white rats. It was shown that the drug caused a significant damage to the mucosa, especially of goblet cells of villi and crypts and interfere with the mucoid secretion. The alterations after mebendazole administ
- PMID 1758363
- Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis.
- Nahmias J, Kennet R, Goldsmith R, Greenberg Z.SourceZevulun Clinic, Kupal Holim, Haifa, Israel.
- Annals of tropical medicine and parasitology.Ann Trop Med Parasitol.1989 Dec;83(6):625-9.
- An effective drug for single-dose mass treatment of necatoriasis was sought by testing three drugs and two drug combinations in Ethiopian immigrants to Israel found to have light infections. The drugs tested sequentially in single-doses were pyrantel pamoate (20 mg kg-1, 81 subjects); bephenium hydr
- PMID 2619378
Japanese Journal
- 十二指腸ファイバースコープ検査で診断された鉤虫症の一例
- Bephenium hydroxynaphthoate(Alcopar)の鉤虫集団駆虫効果について-3-
- 1-Bromo-2-naphthol(オーミン顆粒)とBephenium hydroxynaphthoate(Alcopar)の鉤虫駆除効果比較試験
Related Links
- Bephenium hydroxynaphthoate (INN, trade names Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex) is an anthelmintic agent formerly used in the ... Bephenium is not FDA-approved and is not available in the United States.
- Clinical trials with bephenium hydroxynaphthoate against hookworm in Ceylon. Br Med J. 1958 Dec 27 ... The treatment of hookworm, Ascaris and Trichuris infections with bephenium hydroxynaphthoate. Am J Trop Med Hyg. 1960 Sep ...
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