benzylthiouracil

Benzylthiouracil
Systematic (IUPAC) name
	1-(1-cyclohexa-2,4-dienylmethyl)-7-thia-; 3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Pharmacokinetic data
Excretion	Renal
Identifiers
CAS Registry Number	6336-50-1
ATC code	H03BA03
PubChem	CID 685814
ChemSpider	597542
UNII	PZ35LUM333
ChEMBL	CHEMBL1491306
Chemical data
Formula	C11H10N2OS
Molecular mass	218.276 g/mol
	SMILES S=C1N/C(=C\C(=O)N1)Cc2ccccc2;
	InChI InChI=1S/C11H10N2OS/c14-10-7-9(12-11(15)13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13,14,15) ; Key:PNXBXCRWXNESOV-UHFFFAOYSA-N ;
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/17 20:35:26」(JST)

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Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

Adverse effects

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.^[1]^[2]^[3]^[4]

References

^ Tieulie N, Huong DL, Andreu M et al. (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]". Rev Med Interne (in French) 23 (10): 853–6. doi:10.1016/S0248-8663(02)00694-X. PMID 12428489.
^ Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]". Rev Med Interne (in French) 23 (10): 857–61. doi:10.1016/S0248-8663(02)00704-X. PMID 12428490.
^ Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]". Presse Médicale (in French) 33 (19 Pt 1): 1331–3. doi:10.1016/S0755-4982(04)98919-1. PMID 15615240.
^ Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr 165 (7): 435–6. doi:10.1007/s00431-005-0053-4. PMID 16622664.

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English Journal

[Benzylthiouracil induced ANCA-positive vasculitis].

Baili L, Aydi Z, Daoud F, Ben Dhaou B, Boussema E, Kochbati S, Boussema F.
La Tunisie médicale.Tunis Med.2014 Jun;92(6):428-30.
PMID 25741853

[Benzylthiouracil-induced antineutrophil cytoplasmic antibody-associated cutaneous vasculitis: a case report and literature review].

Chebbi W1, Zantour B, Alaya W, Belhadjali H, Sfar MH.
La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne.Rev Med Interne.2013 Sep;34(9):561-4. doi: 10.1016/j.revmed.2013.05.012. Epub 2013 Jul 1.
INTRODUCTION: Vasculitis associated to antineutrophil cytoplasmic antibodies is a rare complication of therapy with antithyroid medication. They were mainly reported in patients treated with propylthiouracil and rarely with benzylthiouracil.CASE REPORT: We report a 22-year-old woman treated with ben
PMID 23827012

Prevalence of antineutrophil cytoplasmic antibodies during treatment with benzylthiouracil.

Sghiri R1, Ouertani M, Ben Hsine H, Slim I, Chaieb L, Ghedira I.
Pathologie-biologie.Pathol Biol (Paris).2009 Jul;57(5):410-4. doi: 10.1016/j.patbio.2008.11.006. Epub 2009 Feb 6.
BACKGROUND: Drug induced antineutrophil cytoplasmic antibodies (ANCA) associated vasculitis is a rare complication associated especially with propylthiouracil (PTU). Prevalence of ANCA in patients receiving PTU is well established. Few cases of vasculitis were also reported with benzylthiouracil (BT
PMID 19201108

Related Pictures

[1] Tieulie N, Huong DL, Andreu M et al. (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]". Rev Med Interne (in French) 23 (10): 853–6. doi:10.1016/S0248-8663(02)00694-X. PMID 12428489.

[2] Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]". Rev Med Interne (in French) 23 (10): 857–61. doi:10.1016/S0248-8663(02)00704-X. PMID 12428490.

[3] Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]". Presse Médicale (in French) 33 (19 Pt 1): 1331–3. doi:10.1016/S0755-4982(04)98919-1. PMID 15615240.

[4] Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr 165 (7): 435–6. doi:10.1007/s00431-005-0053-4. PMID 16622664.

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