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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/09 06:53:35」(JST)

English Journal

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug.

Lee HS1, Bae T, Lee JH, Kim DG, Oh YS, Jang Y, Kim JT, Lee JJ, Innocenti A, Supuran CT, Chen L, Rho K, Kim S.
BMC systems biology.BMC Syst Biol.2012 Jul 2;6:80. doi: 10.1186/1752-0509-6-80.
BACKGROUND: The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical indications. When successful, this process reduces the risk of failure and costs associat
PMID 22748168

Sirén H1, Shimmo R, Sipola P, Abenet S, Riekkola ML.
Journal of chromatography. A.J Chromatogr A.2008 Jul 11;1198-1199:215-9. doi: 10.1016/j.chroma.2008.05.026. Epub 2008 May 21.
Actual mobilities and dissociation constants of six diuretics (benzthiazide, bumetanide, ethacrynic acid, furosemide, hydrochlorothiazide and chlorothiazide) and probenecid were investigated in methanol by capillary zone electrophoresis (CZE). The actual mobilities were derived from the dependence o
PMID 18534604

Combined effect of solvent content, temperature and pH on the chromatographic behaviour of ionisable compounds.

Pous-Torres S1, Torres-Lapasió JR, Baeza-Baeza JJ, García-Alvarez-Coque MC.
Journal of chromatography. A.J Chromatogr A.2007 Sep 7;1163(1-2):49-62. Epub 2007 Jun 7.
The organic solvent content and the pH in the mobile phase are the usual main factors in reversed-phase liquid chromatographic separations, owing to their strong effects on retention and/or selectivity. Temperature is often neglected. However, even in cases where the impact of this factor on selecti
PMID 17585924

折田義正,高光義博,安東明夫,白井大禄,杉田実,浦壁重治,阿部裕
医化学シンポジウム 10(0), 164-168, 1971
… similarity to the electronic state of the phosphate part of ATP.<BR>This study attempted to demonstrate experimentally the metal chelation of thiazide diuretics and to investigate the effects of this metal chelating action on the activity of Na, K-dependent ATPase which had been prepared from 0.1% DOC treated microsome fragments of the rat kidney cortex.<BR>Reduction potential of a mixed solution of 2mM thiazide diuretics (hydrochlorothiazide, acetothiazide, trichlormethiazide, polythiazide and benzthiazide) with 1mM CuCl<SUB>2</SUB> …
NAID 130003358498

リンク元	「ベンズチアジド」「ベンツチアジド」「ベンズサイアザイド」
拡張検索	「hydrobenzthiazide」

Benzthiazide
Systematic (IUPAC) name
	6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	Oral
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Half-life	5 to 15 hours
Excretion	Renal
Identifiers
CAS number	91-33-8
ATC code	None
PubChem	CID 2343
DrugBank	DB00562
ChemSpider	2253
UNII	1TD8J48L61
KEGG	D00651
ChEBI	CHEBI:3047
ChEMBL	CHEMBL1201039
Chemical data
Formula	C15H14ClN3O4S3
Molecular mass	431.94 g/mol
	SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N;
	InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21) ; Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N ;
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