benzophenanthridine

English Journal

Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways.

Lin J, Shen A, Chen H, Liao J, Xu T, Liu L, Lin J, Peng J1.
BMC cancer.BMC Cancer.2014 Sep 30;14:729. doi: 10.1186/1471-2407-14-729.
BACKGROUND: The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might not always be therapeutically effective. Additionally, long-term use of these
PMID 25266147

Chelidonine, a natural benzophenathridine alkaloid, suppresses breast cancer cells by hTERT down regulation, senescence acceleration and induction of apoptosis and autophagy.

Noureini SK1, Esmaili H2.
Chemico-biological interactions.Chem Biol Interact.2014 Sep 29. pii: S0009-2797(14)00262-2. doi: 10.1016/j.cbi.2014.09.013. [Epub ahead of print]
In a preliminary study screening anti-proliferative natural alkaloids, a very potent benzophenanthridine, chelidonine showed strong cytotoxicity in cancer cells. While several modes of death have been identified, most of anti-cancer attempts have focused on stimulation of cells to undergo apoptosis.
PMID 25265580

Elucidation of the DNA binding specificity of the natural plant alkaloid chelerythrine: a biophysical approach.

Basu P1, Suresh Kumar G2.
Journal of photochemistry and photobiology. B, Biology.J Photochem Photobiol B.2014 Sep 5;138:282-94. doi: 10.1016/j.jphotobiol.2014.06.005. Epub 2014 Jun 18.
Interaction of the anticancer plant alkaloid chelerythrine with four sequence specific synthetic polynucleotides was studied by spectroscopy and calorimetry experiments. The binding resulted in strong hypochromic and bathochromic effects in the absorption spectrum of the alkaloid, enhancement in the
PMID 25010289

The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus

OBIANG-OBOUNOU Brice W,KANG Ok-Hwa,CHOI Jang-Gi,KEUM Joon-Ho,KIM Sung-Bae,MUN Su-Hyun,SHIN Dong-Won,KIM Ki Woo,PARK Chung-Berm,KIM Young-Guk,HAN Sin-Hee,KWON Dong-Yeul
Journal of toxicological sciences 36(3), 277-283, 2011-06-01
… Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. …
NAID 10029135742

Ishikawa Tsutomu,Saito Tatsuru,Kurosawa Ayako,Watanabe Toshiko,Maruyama Sakiko,Ichikawa Yuh-ichiro,Yamada Ryota,Okuzawa Hiroko,Sato Hiromi,Ueno Koichi
CHEMICAL & PHARMACEUTICAL BULLETIN 59(4), 472-475, 2011
Preliminary examination for the structure–activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggeste …
NAID 130000648966