bendrofluazide

Bendroflumethiazide
Systematic (IUPAC) name
	3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy; category	Risk neonatal thrombocytopenia in 3rd trimester;
Legal status	UK: Prescription-only (POM);
Routes of; administration	Oral
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Metabolism	extensive
Biological half-life	3-4 hours
Identifiers
CAS Registry Number	73-48-3
ATC code	C03AA01
PubChem	CID: 2315
IUPHAR/BPS	7122
DrugBank	DB00436
ChemSpider	2225
UNII	5Q52X6ICJI
KEGG	D00650
ChEBI	CHEBI:3013
ChEMBL	CHEMBL1684
Chemical data
Formula	C15H14F3N3O4S2
Molecular mass	421.415 g/mol
	SMILES FC(F)(F)c3c(cc1c(NC(NS1(=O)=O)Cc2ccccc2)c3)S(=O)(=O)N ;
	InChI InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23) ; Key:HDWIHXWEUNVBIY-UHFFFAOYSA-N ;
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関: bendroflumethiazide

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/17 23:15:15」(JST)

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[Wiki en表示]

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Adverse effects

Common adverse effects:^[3]

postural hypotension
hyponatraemia, hypokalaemia, hypercalcaemia
gout
impaired glucose tolerance
impotence
fatigue
pulmonary oedema
pneumonitis

Rare adverse effects:^[4]

thrombocytopenia
agranulocytosis
photosensitivity rash
pancreatitis
renal insufficiency

Alcohol

Bendroflumethiazide is known to have an adverse interaction with alcohol. It is advised that those using this diuretic should abstain from alcohol consumption during use, as it is possible to experience a sudden drop in blood pressure, especially if standing up.

Other considerations

Bendroflumethiazide should not be used by pregnant women, or women who have just given birth. Due to the nature of the medication, it is possible for it to pass into the breast milk and consequently to the child. It is also known that bendroflumethiazide suppresses the production of breast milk. Pregnant or lactating women with hypertension may need to discuss with their prescriber as to which alternative treatment may be more suitable. Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving.^[5]

References

^ BNF 45 March 2003
^ Ed. Sean C. Sweetman (ed.). Martindale: The complete drug reference (33 ed.). Pharmaceutical Press.
^ Bendroflumethiazide Side Effects - Common euroClinix.co.uk
^ Bendroflumethiazide Side Effects Drugs.com
^ Bendroflumethiazide (Bendroflumethiazide 2.5mg tablets) NHS.uk

English Journal

Quantification of 21 antihypertensive drugs in serum using UHPLC-MS/MS.

Gundersen POM1, Helland A2, Spigset O3, Hegstad S4.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2018 Jul 1;1089:84-93. doi: 10.1016/j.jchromb.2018.04.038. Epub 2018 Apr 28.
PMID 29783197

Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method.

Fornells E1, Fuguet E2, Mañé M1, Ruiz R3, Box K4, Bosch E5, Ràfols C6.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2018 May 30;117:227-235. doi: 10.1016/j.ejps.2018.02.025. Epub 2018 Feb 23.
PMID 29481859

Spontaneous and α-adrenoceptor-induced contractility in human collecting lymphatic vessels require chloride.

Mohanakumar S1,2,3, Majgaard J1,3, Telinius N1,3, Katballe N2,3, Pahle E4, Hjortdal V2,3, Boedtkjer D1,2,3.
American journal of physiology. Heart and circulatory physiology.Am J Physiol Heart Circ Physiol.2018 Aug 1;315(2):H389-H401. doi: 10.1152/ajpheart.00551.2017. Epub 2018 Apr 6.
PMID 29631375