WordNet

a virus that is parasitic (reproduces itself) in bacteria; "phage uses the bacteriums machinery and energy to produce more phage until the bacterium is destroyed and phage is released to invade surrounding bacteria" (同)phage

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1. ゲノミクスおよびモデルシステム genomics and model systems
2. メチシリン耐性黄色ブドウ球菌の迅速な検出 rapid detection of methicillin resistant staphylococcus aureus
3. 結核の微生物学および病因 microbiology and pathogenesis of tuberculosis
4. コレラ菌感染の病因 pathogenesis of vibrio cholerae infection
5. ジフテリアの疫学、病態生理および臨床症状 epidemiology pathophysiology and clinical manifestations of diphtheria

Cancer-specific binary expression system activated in mice by bacteriophage HK022 Integrase.

Elias A1, Spector I1, Sogolovsky-Bard I1, Gritsenko N1, Rask L2,3, Mainbakh Y1, Zilberstein Y1, Yagil E1, Kolot M1.
Scientific reports.Sci Rep.2016 Apr 27;6:24971. doi: 10.1038/srep24971.
Binary systems based on site-specific recombination have been used for tumor specific transcription targeting of suicide genes in animal models. In these binary systems a site specific recombinase or integrase that is expressed from a tumor specific promoter drives tumor specific expression of a cyt
PMID 27117628

Tawk CS1, Ghattas IR1, Smith CA2.
Journal of bacteriology.J Bacteriol.2015 Nov;197(22):3573-82. doi: 10.1128/JB.00466-15. Epub 2015 Sep 8.
Bacteriophage λ N protein binds boxB RNA hairpins in the nut (N utilization) sites of immediate early λ transcripts and interacts with host factors to suppress transcriptional termination at downstream terminators. In opposition to λ N, the Nun protein of HK022 binds the boxBs of coinfecting λ t
PMID 26350130

Vitiello CL1, Kireeva ML2, Lubkowska L2, Kashlev M3, Gottesman M4.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Jun 10;111(23):E2368-75. doi: 10.1073/pnas.1319740111. Epub 2014 May 22.
The Nun protein of coliphage HK022 arrests RNA polymerase (RNAP) in vivo and in vitro at pause sites distal to phage λ N-Utilization (nut) site RNA sequences. We tested the activity of Nun on ternary elongation complexes (TECs) assembled with templates lacking the λ nut sequence. We report that Nu
PMID 24853501