関: apazone

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/11 18:04:59」(JST)

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Azapropazone is a non-steroidal anti-inflammatory drug. It is manufactured by Goldshield under the tradename Rheumox.^[1]

It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects.^[2] Azopropazone has now been discontinued in the British National Formulary.

Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized.^[3]

References

^ http://home.intekom.com/pharm/cont_eth/rheumox.html
^ http://www.patient.co.uk/showdoc/30002267/
^ Jones CJ (1976). "The pharmacology and pharmacokinetics of azapropazone - a review". Curr Med Res Opin 4 (1): 3–16. doi:10.1185/03007997609109361. PMID 770078.

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Japanese Journal

難治性ネフローゼ症候群(ネ症)の尿蛋白減少目的のため Azapropazone を試みた Alport 症候群の1男児例

笠原多加幸,山崎恒,大久保総一郎,早川広史,内山聖
日本小児腎不全学会雑誌 : 小児腎不全研究会記事 20, 225-227, 2000-08-31
NAID 10013032275

ループス腎炎に対するアザプロパゾンの抗蛋白尿効果

山辺英彰,小沢一浩,福士一彦,大沢弘,千葉実行,小野寺庚午
弘前醫學 39(4), 546-550, 1987-12
NAID 110004770818

Effect of azapropazone and allopurinol on myocardial infarct size in rats

MONTOR SG
Eur J Pharmacol 140, 203-207, 1987
NAID 30002504586

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リンク元	「apazone」「アザプロパゾン」

「apazone」

Azapropazone
Systematic (IUPAC) name
	(RS)-5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
Clinical data
Trade names	Rheumox
AHFS/Drugs.com	International Drug Names
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Biological half-life	20 hours
Identifiers
CAS Number	13539-59-8
ATC code	M01AX04 (WHO)
PubChem	CID 26098
ChemSpider	24310
UNII	K2VOT966ZI
KEGG	D02966
ChEBI	CHEBI:38010
ChEMBL	CHEMBL1231131
Chemical data
Formula	C16H20N4O2
Molar mass	300.36 g/mol
Chirality	Racemic mixture
	SMILES O=C3N/1N(c2c(\N=C\1N(C)C)ccc(c2)C)C(=O)C3CCC ;
	InChI InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3 ; Key:MPHPHYZQRGLTBO-UHFFFAOYSA-N ;
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