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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/11 18:04:59」(JST)
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Azapropazone
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Systematic (IUPAC) name |
(RS)-5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
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Clinical data |
Trade names |
Rheumox |
AHFS/Drugs.com |
International Drug Names |
Legal status |
Legal status |
- UK: POM (Prescription only)
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Pharmacokinetic data |
Biological half-life |
20 hours |
Identifiers |
CAS Number |
13539-59-8 N |
ATC code |
M01AX04 (WHO) |
PubChem |
CID 26098 |
ChemSpider |
24310 Y |
UNII |
K2VOT966ZI Y |
KEGG |
D02966 Y |
ChEBI |
CHEBI:38010 Y |
ChEMBL |
CHEMBL1231131 N |
Chemical data |
Formula |
C16H20N4O2 |
Molar mass |
300.36 g/mol |
Chirality |
Racemic mixture |
SMILES
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O=C3N/1N(c2c(\N=C\1N(C)C)ccc(c2)C)C(=O)C3CCC
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InChI
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InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3 Y
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Key:MPHPHYZQRGLTBO-UHFFFAOYSA-N Y
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NY (what is this?) (verify) |
Azapropazone is a non-steroidal anti-inflammatory drug. It is manufactured by Goldshield under the tradename Rheumox.[1]
It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects.[2] Azopropazone has now been discontinued in the British National Formulary.
Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized.[3]
References
- ^ http://home.intekom.com/pharm/cont_eth/rheumox.html
- ^ http://www.patient.co.uk/showdoc/30002267/
- ^ Jones CJ (1976). "The pharmacology and pharmacokinetics of azapropazone - a review". Curr Med Res Opin 4 (1): 3–16. doi:10.1185/03007997609109361. PMID 770078.
Prostanoid signaling
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Receptor
(ligands) |
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Enzyme
(inhibitors) |
COX (PTGS) |
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PGD2 synthase |
- Retinoids
- Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
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PGE synthase |
HQL-79
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PGF synthase |
Bimatoprost
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PGI2 synthase |
Tranylcypromine
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TXA synthase |
- Camonagrel
- Dazmegrel
- Dazoxiben
- Furegrelate
- Isbogrel
- Midazogrel
- Nafagrel
- Nicogrelate
- Ozagrel
- Picotamide
- Pirmagrel
- Ridogrel
- Rolafagrel
- Samixogrel
- Terbogrel
- U63557A
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Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
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See also: Leukotrienergics
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UpToDate Contents
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English Journal
- Evaluation of the biointeraction of colorant flavazin with human serum albumin: insights from multiple spectroscopic studies, in silico docking and molecular dynamics simulation.
- Peng W1, Ding F, Jiang YT, Sun Y, Peng YK.
- Food & function.Food Funct.2014 Jun;5(6):1203-17. doi: 10.1039/c3fo60712g. Epub 2014 Apr 7.
- Azo compounds are the largest chemical class of agents frequently used as colorants in a variety of consumer goods and farm produce; therefore, they may become a hazard to public health, because numerous azo compounds and their metabolites are proven to be carcinogens and mutagens. Herein several qu
- PMID 24705828
- Bioavailability and activity of natural food additive triterpenoids as influenced by protein.
- Peng W1, Ding F, Jiang YT, Peng YK.
- Journal of agricultural and food chemistry.J Agric Food Chem.2014 Mar 12;62(10):2271-83. doi: 10.1021/jf4049512. Epub 2014 Feb 26.
- Triterpenoids were thought to be biologically ineffective for a very long time, but aggregating proof on their widely ranging pharmacological activities paired with a dubious toxicity portrait has motivated regenerated attraction for human health and disease. In the current contribution, our central
- PMID 24548018
- Characteristics and essences upon conjugation of imidacloprid with two model proteins.
- Ding F1, Peng W, Diao JX, Zhang L, Sun Y.
- Journal of agricultural and food chemistry.J Agric Food Chem.2013 May 15;61(19):4497-505. doi: 10.1021/jf3048065. Epub 2013 Apr 30.
- Since the introduction of imidacloprid in the early 1990s, it has become one of the most widely applied insecticides, and currently represents about 20% of the global pesticide market (Tomizawa, M.; Casida, J. E. J. Agric. Food Chem 2011, 59, 2883-2886). In the context of this study, our major aim w
- PMID 23530963
Japanese Journal
- 難治性ネフローゼ症候群(ネ症)の尿蛋白減少目的のため Azapropazone を試みた Alport 症候群の1男児例
- 笠原 多加幸,山崎 恒,大久保 総一郎,早川 広史,内山 聖
- 日本小児腎不全学会雑誌 : 小児腎不全研究会記事 20, 225-227, 2000-08-31
- NAID 10013032275
- Effect of azapropazone and allopurinol on myocardial infarct size in rats
Related Links
- Azapropazoneとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Azapropazoneとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
- Azapropazone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Azapropazone is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on ...
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