avidity

関

affinity

• the total binding strength of a molecule with more than one binding site is called its avidity (IMM.740)
• 機能的親和力。例えば、5量体IgMと抗原との間の平衡定数が大きいとき、アビディティーが大きいという。

　

WordNet

1. a natural attraction or feeling of kinship; "an affinity for politics"; "the mysterious affinity between them"; "Jamess affinity with Sam"
2. inherent resemblance between persons or things
3. the force attracting atoms to each other and binding them together in a molecule; "basic dyes have an affinity for wool and silk" (同)chemical attraction
4. a close connection marked by community of interests or similarity in nature or character; "found a natural affinity with the immigrants"; "felt a deep kinship with the other students"; "anthropologys kinship with the humanities" (同)kinship
5. (biology) state of relationship between organisms or groups of organisms resulting in resemblance in structure or structural parts; "in anatomical structure prehistoric man shows close affinity with modern humans" (同)phylogenetic relation
6. (anthropology) kinship by marriage or adoption; not a blood relationship
7. (immunology) the attraction between an antigen and an antibody
8. technical terms for pregnancy (同)gravidness, gravidation

PrepTutorEJDIC

1. どん欲;渇望,熱望
2. 〈C〉(人・物に対する)好み,親近感《+『for』(『to, with』)+『名』》 / 〈U〉〈C〉(2者の間の)密接な関係,類似《+『between』+『名』》;(…との)類縁《+『with』+『名』》 / 〈U〉〈C〉親和力(原子が化学反応を起こしやすい力)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/27 15:33:44」(JST)

wiki en

[Wiki en表示]

In proteins, avidity is the combined strength of multiple bond interactions. Avidity is distinct from affinity, which is the strength of a single bond. As such, avidity is the combined synergistic strength of bond affinities rather than the sum of bonds.

It is commonly applied to antibody interactions in which multiple antigen binding sites simultaneously interact with a target. Individually, each binding interaction may be readily broken, however, when many binding interactions are present at the same time, transient unbinding of a single site does not allow the molecule to diffuse away, and binding of that site is likely to be reinstated. The overall effect is synergistic, strong binding of antigen to antibody (e.g. IgM is said to have low affinity but high avidity because it has 10 weak binding sites as opposed to the 2 strong binding sites of IgG, IgE and IgD).

If the clustered proteins form a matrix, such as a clathrin-coat, the interaction is a matricity.

See also

• Amino acid residue
• Epitope
• Fab region
• Hapten

External links

• Antibody+Avidity at the US National Library of Medicine Medical Subject Headings (MeSH)

References

• Roitt, Ivan, et al., Immunology, 6th edn, 2001, Mosby Publishers, page 72.

Micro Class at SIUE

UpToDate Contents

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• 1. 妊娠中のサイトメガロウイルス感染 cytomegalovirus infection in pregnancy
• 2. トキソプラズマ感染に対する診断的評価 diagnostic assays for toxoplasmosis infection
• 3. 造血細胞移植レシピエントにおけるヒトヘルペスウイルス6感染 human herpesvirus 6 infection in hematopoietic cell transplant recipients
• 4. 免疫宿主におけるトキソプラズマ症 toxoplasmosis in immunocompetent hosts
• 5. 免疫グロブリンの機能および臨床応用 function and clinical applications of immunoglobulins

English Journal

• Rapidly Growing Complex Fibroadenoma With Surrounding Ductal Hyperplasia Mimics Breast Malignancy on Serial F-18 FDG PET/CT Imaging.

• Makis W, Ciarallo A, Hickeson M, Derbekyan V.SourceFrom the *Department of Nuclear Medicine, Brandon Regional Health Centre, Brandon, Canada; and †Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
• Clinical nuclear medicine.Clin Nucl Med.2011 Jul;36(7):576-9.
• A 30-year-old woman was referred for an F-18 fluorodeoxyglucose (FDG) PET/CT to rule out lymphoma, and was found to have an incidental FDG-avid right breast nodule that grew significantly in size and FDG uptake on a subsequent scan, raising suspicion of a growing breast malignancy. Histologic evalua
• PMID 21637064

• F-18 FDG PET/CT as a Crucial Guide Toward Optimal Treatment Planning in a Case of Postirradiation Sarcoma 10 Years After Primary Bone Lymphoma of the Pelvis.

• de Rooy JW, Hambrock T, Vriens D, Flucke UE, van der Geest IC, van de Luijtgaarden AC, Schreuder BW, de Geus-Oei LF.SourceFrom the Departments of *Radiology, †Nuclear Medicine, ‡Pathology, §Orthopedic Surgery, and ¶Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
• Clinical nuclear medicine.Clin Nucl Med.2011 Jul;36(7):565-7.
• Ten years after chemoradiation for primary lymphoma of the left pelvic bone, a 38-year-old man presented with a 4-month history of gradually increasing pain in his left upper leg and thigh. Initial radiographs and contrast-enhanced magnetic resonance imaging were consistent with recurrent lymphoma,
• PMID 21637060

Japanese Journal

• Protein-based Open Sandwich Immuno-PCR for Sensitive Detection of Small Biomarkers

• HASAN Sharif,DONG Jinhua,HARA Yuko [他]
• Analytical Sciences 29(9), 871-876, 2013-09
• NAID 40019779868

• The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis

• Kuroki Kimiko,Hirose Kaoru,Okabe Yuki,Fukunaga Yuko,Takahashi Ami,Shiroishi Mitsunori,Kajikawa Mizuho,Tabata Shigekazu,Nakamura Seiko,Takai Toshiyuki,Koyanagi Satoru,Ohdo Shigehiro,Maenaka Katsumi
• HUMAN IMMUNOLOGY 74(4), 433-438, 2013-04
• … In accordance with this result, a binding study revealed that the HLA-G dimer binds PIR-B, the mouse homolog of the LILRBs, with higher affinity and avidity than the monomer. …
• NAID 120005297913

• P3-15-7 母体血サイトメガロウイルスIgG avidity測定による先天性感染の発生予知(Group 120 周産期・感染症,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

• 森上 聡子,蝦名 康彦,平久 進也,谷村 憲司,森岡 一朗,園山 綾子,峰松 俊夫,山田 秀人
• 日本産科婦人科學會雜誌 65(2), 897, 2013-02-01
• NAID 110009639431

Related Links

• Avidity

Avidity develops and sells molecular affinity tools for connecting molecules. Our patented AviTag? technology employs a highly targeted enzymatic conjugation of a single biotin on a unique 15 amino acid peptide tag using the biotin ...

Related Pictures

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★リンクテーブル★

リンク元	「affinity」「結合力」「結合活性」「アビディティー」「associative strength」
拡張検索	「avidity index」「antibody avidity」

「affinity」

　　[★]

同

親和性、アフィニティー

関

avidity

• 固有親和力
• 例えば、抗体の一方の抗原結合部位とB細胞エピトープとの間の平衡定数で表されるような親和性を指す

　 　 　 　 　 　 　 　

「結合力」

　　[★]

英

avidity、associative strength, binding force

関

アビディティー、結合活性、アフィニティー

「結合活性」

　　[★]

英

avidity

関

アビディティー、結合力

「アビディティー」

　　[★]

英

avidity

関

結合活性、結合力

「associative strength」

　　[★]

• 結合力

関

avidity

「avidity index」

　　[★]

• ELISAによる抗体の定量する際に用いられる指標
• 一次抗体(検体)を結合させた後、8M尿素処理により低いavidityの抗体を抗体から離脱させ、二次抗体の反応量を検出
• 8M尿素処理しないものとの反応量の比をとり、avidity indexとする。
• ウイルスの初感染ではavidity indexが低いはずである。
• 鑑別に用いられるウイルス：風疹ウイルス、サイトメガロウイルス、水痘ウイルス、トキソプラズマ

「antibody avidity」

　　[★]

• 抗体結合活性

関

antibody affinity