English Journal

Analysis of 21-hydroxy deflazacort in human plasma by UPLC-MS/MS: application to a bioequivalence study in healthy volunteers.

Patel DP, Sharma P, Patel BM, Sanyal M, Singhal P, Shrivastav PS.SourceDepartment of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, India.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Nov;85:213-7. doi: 10.1016/j.jpba.2013.07.035. Epub 2013 Aug 6.
A sensitive and rapid ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method has been developed for the determination of 21-hydroxy deflazacort in human plasma using betamethasone as the internal standard (IS). After solid-phase extraction from 100 μL human plasma, th
PMID 23973630

LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.

Xu Y, Yuan Y, Smith L, Edom R, Weng N, Mamidi R, Silva J, Evans DC, Lim HK.SourceDrug Safety Sciences, Janssen Research & Development, 1400 McKean Road, Spring House, PA 19477, USA.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Nov;85:145-54. doi: 10.1016/j.jpba.2013.07.016. Epub 2013 Jul 25.
A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) assay was developed and qualified for analyzing 4β-hydroxycholesterol and cholesterol in 5 μl of human and mouse plasma. Stable isotope-labeled d7-analogs of both analytes were used as internal standards and 4.
PMID 23948760

Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.

Ahn G, Park DM, Park JW, Cho JY, Rhee SJ, Kim HY, Lee DS, Jang IJ, Kim HK.SourceBiomolecular Function Research Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2013 Oct 15. [Epub ahead of print]
There is an increasing need for more sensitive analytical methods in pharmacokinetic studies, for example, for phase 0 clinical trials. A novel HPLC Chip-triple quadrupole mass spectrometer method (HPLC Chip-MS/MS method) for the quantification of 7-ethyl-10-hydroxycamptothecin (SN38) was developed,
PMID 24126840