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1. インスリン受容体の構造および機能 structure and function of the insulin receptor

English Journal

EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR.

Furcht CM1, Buonato JM1, Lazzara MJ2.
Science signaling.Sci Signal.2015 May 12;8(376):ra46. doi: 10.1126/scisignal.2005697.
Complexes of signaling proteins that are nucleated upon activation of receptor tyrosine kinases are dynamic macromolecular assemblies held together by interactions, such as the recognition of phosphotyrosines by Src homology 2 (SH2) domains. We predicted that reversible binding and phosphatase activ
PMID 25969544

A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity.

Rocker A1, Meinhart A.
Molecular microbiology.Mol Microbiol.2015 May 6. doi: 10.1111/mmi.13051. [Epub ahead of print]
Toxin-antitoxin (TA) systems are widespread genetic modules in the genomes of bacteria and archaea emerging as key players that modulate bacterial physiology. They consist of two parts, a toxic component that blocks an essential cellular process and an antitoxin that inhibits this toxic activity dur
PMID 25943309

Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions.

Aponte-Santamaría C1, Huck V2, Posch S3, Bronowska AK1, Grässle S2, Brehm MA4, Obser T4, Schneppenheim R4, Hinterdorfer P3, Schneider SW2, Baldauf C5, Gräter F6.
Biophysical journal.Biophys J.2015 May 5;108(9):2312-21. doi: 10.1016/j.bpj.2015.03.041.
Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to the shielding of its adhesion sites and proteolytic cleavage. However, the molecular nature of this shielding and
PMID 25954888

Japanese Journal

Escherichia coli acid resistance : pH-sensing, activation by chloride and autoinhibition in GadB

GUT H.
EMBO J. 25, 2643-2651, 2006
NAID 80019095056

Structural analysis of autoinhibition in the Ras activator Son of sevenless

SONDERMANN H
Cell 119, 393-405, 2004
NAID 80017005535

Related Links

Enzyme induction and inhibition - Wikipedia, the free encyclopedia

If the molecule induces enzymes that are responsible for its own metabolism, this is called auto-induction (or auto-inhibition if there is inhibition). These processes are particular forms of gene expression regulation. These terms are of particular ...

autoinhibited - Wiktionary

[edit] Adjective. autoinhibited (comparative more autoinhibited, superlative most autoinhibited). Subject to, or produced by autoinhibition. Retrieved from "http://en. wiktionary.org/w/index.php?title=autoinhibited&oldid=17152574". Categories: ...