関: astromicin sulfate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/05 08:23:32」(JST)

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Astromicin (INN)(also frequently referenced in scientific journal articles as compounds Fortimicin A/B ) is an aminoglycoside antibiotic. Synthesized from Micromonospora olivasterospora(also named with additional o in olivoasterospora).

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English Journal

[Cloning and sequence characterization of replication region in plasmid pJTU112 from Micoromonospora sp. 40027].

Geng X1, Chen X, Yang X, Guo J, Zhai G, Li X.
Wei sheng wu xue bao = Acta microbiologica Sinica.Wei Sheng Wu Xue Bao.2013 Jun 4;53(6):623-7.
Micoromonospora sp. 40027, the producer of fortimicin A, harbors two plasmids pJTU101 and pJTU112.OBJECTIVE: Cloning and sequencing of replication region of pJTU12, analyzing replication region sequence of pJTU112.METHODS: Different fragments of pJTU112 were cloned and introduced by conjugation into
PMID 24028065

Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa.

Kim C1, Villegas-Estrada A, Hesek D, Mobashery S.
Biochemistry.Biochemistry.2007 May 1;46(17):5270-82. Epub 2007 Apr 7.
A recently discovered bifunctional antibiotic-resistance enzyme named AAC(3)-Ib/AAC(6')-Ib', from Pseudomonas aeruginosa, catalyzes acetylation of aminoglycoside antibiotics. Since both domains are acetyltransferases, each was cloned and purified for mechanistic studies. The AAC(3)-Ib domain appears
PMID 17417880

Vector systems allowing efficient autonomous or integrative gene cloning in Micromonospora sp. strain 40027.

Li X1, Zhou X, Deng Z.
Applied and environmental microbiology.Appl Environ Microbiol.2003 Jun;69(6):3144-51.
Vector systems allowing autonomous or site-specific integrative gene cloning were developed for Micromonospora sp. strain 40027, a producer of the antibiotic fortimicin A. The autonomous system depends on the discovery of a low-copy-number, self-transmissible covalently closed circular plasmid, pJTU
PMID 12788709

Japanese Journal

アミノ配糖体抗生物質のイオン交換HPLC分析

横山洋子,浜名康栄
群馬保健学紀要 25, 183-189, 2005-03-00
アミノ配糖体(アミノグリコシド)抗生物質の作用機序と細菌のポリアミン合成との関係を研究するために,アミノ配糖体抗生物質を高性能液体クロマトグラフイー(HPLC)分析で分離・定量することを検討した。ポリアミン分析に用いているクエン酸/塩化ナトリウム溶難液による段階/直線塩濃度勾配溶出法による強酸性陽イオン交換HPLC法が,カナマイシン,ゲンタマイシン,アミカシン,フラジオマイシン,ストレプトマイシン …
NAID 110004599274

アミノ配糖体系抗生物質Arbekacin, Astromicin, IsepamicinとNetilmicinの筋弛緩作用

遠藤和敬
The Japanese journal of antibiotics 52(8), 554-561, 1999-08-25
NAID 10004901492

Mechanism of Multiple Aminoglycoside Resistance of Kasugamycin-producing Streptomyces kasugaensis MB273: Involvement of Two Types of Acetyltransferases in Resistance to Astromicin Group Antibiotics

HOTTA Kunimoto,OGATA Tetsu,ISHIKAWA Jun,OKANISHI Masanori,MIZUNO Satoshi,MORIOKA Moto,HAGANAWA Hiroshi,OKAMI Yoshiro
Journal of antibiotics 49(7), 682-688, 1996-07-25
NAID 10005517132

「アストロマイシン」

Astromicin
Systematic (IUPAC) name
	2-amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
Legal status
Legal status	℞ (Prescription only);
Identifiers
CAS Number	55779-06-1
ATC code	none
PubChem	CID 65345
ChemSpider	4447577
UNII	7JHD84H15J
KEGG	D07470
ChEBI	CHEBI:37923
ChEMBL	CHEMBL1909053
Chemical data
Formula	C17H35N5O6
Molar mass	405.48 g/mol
3D model (Jmol)	Interactive image
	SMILES O=C(N(C)[C@@H]2[C@@H](OC)[C@@H](O)[C@H](N)[C@@H](O[C@H]1O[C@H]([C@@H](N)C)CC[C@H]1N)[C@@H]2O)CN ;
	InChI InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1 ; Key:BIDUPMYXGFNAEJ-APGVDKLISA-N ;
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