アリールスルファターゼ、アリルスルファターゼ
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/23 11:02:35」(JST)
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Arylsulfatase |
Identifiers |
EC number |
3.1.6.1 |
CAS number |
9016-17-5 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Arylsulfatase (EC 3.1.6.1, sulfatase, nitrocatechol sulfatase, phenolsulfatase, phenylsulfatase, p-nitrophenyl sulfatase, arylsulfohydrolase, 4-methylumbelliferyl sulfatase, estrogen sulfatase) is a type of sulfatase enzyme with system name aryl-sulfate sulfohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- a phenol sulfate + H2O a phenol + sulfate
This group of enzymes has similar specificities.
Types include:
- Arylsulfatase A (also known as "cerebroside-sulfatase") -- a deficiency of this type is associated with metachromatic leukodystrophy
- Arylsulfatase B (also known as "N-Acetylgalactosamine-4-Sulfatase")
- Steroid sulfatase (formerly known as "Arylsulfatase C")
- ARSC2
- ARSD
- ARSE
- ARSF
- ARSG
- ARSH
- ARSI
- ARSJ
- ARSK
See also
References
- ^ Dodgson, K.S., Spencer, B. and Williams, K. (1956). "Studies on sulphatases. 13. The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metacaligenes". Biochem. J. 64 (2): 216–221. PMC 1199721. PMID 13363831.
- ^ Roy, A.B. (1960). "The synthesis and hydrolysis of sulfate esters". Adv. Enzymol. Relat. Subj. Biochem. 22: 205–235. PMID 13744184.
- ^ Roy, A.B. (1976). "Sulphatases, lysosomes and disease". Aust. J. Exp. Biol. Med. Sci. 54 (2): 111–135. doi:10.1038/icb.1976.13. PMID 13772.
- ^ Webb, E.C. and Morrow, P.F.W. (1959). "The activation of an arysulphatase from ox liver by chloride and other anions". Biochem. J. 73 (1): 7–15. PMC 1197004. PMID 13843260.
Hydrolase: esterases (EC 3.1)
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3.1.1: Carboxylic ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
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3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
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3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Phosphoprotein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Phosphoprotein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
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3.1.4: Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
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3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
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Nuclease (includes
deoxyribonuclease and
ribonuclease) |
3.1.11-16: Exonuclease |
Exodeoxyribonuclease |
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Exoribonuclease |
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3.1.21-31: Endonuclease |
Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
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Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
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either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Sixteen novel mutations in the arylsulfatase A gene causing metachromatic leukodystrophy.
- Luzi P, Rafi MA, Rao HZ, Wenger DA.SourceLysosomal Diseases Testing Laboratory, Department of Neurology, Thomas Jefferson University, 1020 Locust Street, Room 346, Philadelphia, PA 19107, USA. Electronic address: paola.luzi@jefferson.edu.
- Gene.Gene.2013 Nov 10;530(2):323-8. doi: 10.1016/j.gene.2013.08.065. Epub 2013 Aug 31.
- Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused mainly by mutations in the arylsulfatase A (ARSA) gene. In this manuscript we report sixteen novel mutations identified in the ARSA gene of fifteen unrelated patients affected with MLD. Of these 16 mutations nine were missense
- PMID 24001781
- The Genome of the Alga-Associated Marine Flavobacterium Formosa agariphila KMM 3901T Reveals a Broad Potential for Degradation of Algal Polysaccharides.
- Mann AJ, Hahnke RL, Huang S, Werner J, Xing P, Barbeyron T, Huettel B, Stüber K, Reinhardt R, Harder J, Glöckner FO, Amann RI, Teeling H.SourceMax Planck Institute for Marine Microbiology, Bremen, Germany.
- Applied and environmental microbiology.Appl Environ Microbiol.2013 Nov;79(21):6813-22. doi: 10.1128/AEM.01937-13. Epub 2013 Aug 30.
- In recent years, representatives of the Bacteroidetes have been increasingly recognized as specialists for the degradation of macromolecules. Formosa constitutes a Bacteroidetes genus within the class Flavobacteria, and the members of this genus have been found in marine habitats with high levels of
- PMID 23995932
- Direct tandem mass spectrometric profiling of sulfatides in dry urinary samples for screening of metachromatic leukodystrophy.
- Kuchař L, Asfaw B, Poupětová H, Honzíková J, Tureček F, Ledvinová J.SourceInstitute of Inherited Metabolic Diseases, First Faculty of Medicine and General Teaching Hospital, Charles University, 128 08 Prague, Czech Republic.
- Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2013 Oct 21;425:153-9. doi: 10.1016/j.cca.2013.06.027. Epub 2013 Jul 6.
- BACKGROUND: Prediagnostic steps in suspected metachromatic leukodystrophy (MLD) rely on clinical chemical methods other than enzyme assays. We report a new diagnostic method which evaluates changes in the spectrum of molecular types of sulfatides (3-O-sulfogalactosyl ceramides) in MLD urine.METHODS:
- PMID 23838369
Japanese Journal
- Comparison of Candidate Pairs of Hydrolytic Enzymes for Spectrophotometric-dual-enzyme-simultaneous-assay
- LIU Hongbo,YUAN Mei,YANG Xiaolan [他],HU Xiaolei,LIAO Juan,DANG Jizheng,XIE Yanling,PU Jun,LI Yuanli,ZHAN Chang-Guo,LIAO Fei
- Analytical Sciences 31(5), 421-427, 2015
- … Pseudomonas aeruginosa arylsulfatase (PAAS) and acetylcholinesterase (AChE) on their substrates derived from 4-nitrophenol/analogue served as candidate label B, and were compared for SDESA with an engineered alkaline phosphatase of Eschrichia coli (ECAP). …
- NAID 130005067338
- Establishment of a Method for Analyzing the Zilpaterol Residue in Beef Using Tandem Mass Spectrometry
- Kim Jae-Young,Chae Young-Sik,Moon Jin-Ah,Baek Seung-Hwa
- Food Science and Technology Research 20(6), 1165-1171, 2014
- … Before sample extraction, a beef sample was hydrolyzed by beta-glucuronidase/arylsulfatase and 0.2 M ammonium acetate buffer solution. …
- NAID 130004848131
- Genome-Wide Association Study in Musician's Dystonia: A Risk Variant at the Arylsulfatase G Locus?
- Lohmann K,Schmidt A,Schillert A,Winkler S,Albanese A,Baas F,Bentivoglio AR,Borngraber F,Bruggemann N,Defazio G,Del Sorbo F,Deuschl G,Edwards MJ,Gasser T,Gomez-Garre P,Graf J,Groen JL,Grunewald A,Hagenah J,Hemmelmann C,Jabusch HC,Kaji R,Kasten M,Kawakami H,Kostic VS,Liguori M,Mir P,Munchau A,Ricchiuti F,Schreiber S,Siegesmund K,Svetel M,Tijssen MAJ,Valente EM,Westenberger A,Zeuner KE,Zittel S,Altenmuller E,Ziegler A,Klein C
- MOVEMENT DISORDERS 29(7), 921-927, 2014
- NAID 120005597264
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- arylsulfatase a group of enzymes active in the hydrolysis of sulfates and the metabolism of mucopolysaccharides; found in liver, pancreas, kidneys and immature monocytes. Several species of molluscs and Aerobacter spp. serve as ...
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