Japanese Journal

Synthesis of N^3-Substituted Uridine and Related Pyrimidine Nucleosides and Their Antinociceptive Effects in Mice

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Chemical & pharmaceutical bulletin 53(3), 313-318, 2005-03-01
… Seventy eight N^3-substituted derivatives of uridine (1), thymidine (2), 2'-deoxyuridine (3), 6-azauridine (4), 2', 3'-O-isopropylideneuridine (5), and arabinofuranosyluracil (6) were synthesized and their antinociceptive effects were evaluated. … N^3-(2', 4'-Dimethoxyphenacyl)uridine (1l), N^3-(2', 4'-dimethoxyphenacyl)2'-deoxyuridine (3l), and N^3-(2', 5'-dimethoxyphenacyl)arabinofuranosyluracil (6m) possessed 93, 86, and 82% of the antinociceptive effects tested by hot plate, respectively. …
NAID 10016652649

尾崎広明,〓原正靖,澤井宏明
有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 62(12), 1238-1248, 2004-12-01
… 5-Substituted 2 '-deoxyuridine derivatives and 5-substituted arabinofuranosyluracil derivatives were synthesized from 2, 2 '-anhydro-5-methoxycarbonylmethyluridine, which was synthesized from arabinoaminooxazoline and dimethyl α-bromomethylfumarate. …
NAID 10014119789