aquaporin 3

アクアポリン3 AQP3

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/13 06:15:20」(JST)

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AQP3
Identifiers
Aliases	AQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
External IDs	OMIM: 600170 MGI: 1333777 HomoloGene: 21025 GeneCards: AQP3
Gene ontology Molecular function • transporter activity • water channel activity • glycerol channel activity Cellular component • cytoplasm • integral component of membrane • membrane • cell-cell junction • plasma membrane • basolateral plasma membrane • nucleus Biological process • positive regulation of immune system process • excretion • response to vitamin D • response to retinoic acid • water transport • urea transport • odontogenesis • response to calcium ion • renal water homeostasis • transport • regulation of keratinocyte differentiation • renal water absorption • glycerol transport • cellular response to oxygen-glucose deprivation • cellular response to hypoxia Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	360	11828
Ensembl	ENSG00000165272	ENSMUSG00000028435
UniProt	Q92482	Q8R2N1
RefSeq (mRNA)	NM_004925 NM_001318144	NM_016689
RefSeq (protein)	NP_001305073 NP_004916	NP_057898.2 NP_057898
Location (UCSC)	Chr 9: 33.44 – 33.45 Mb	Chr 4: 41.09 – 41.1 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells. In the kidney, AQP3 is regulated by vasopressin (ADH). This protein is also a determinant for the GIL blood group system.

See also

• Aquaporin

References

Further reading

• Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte.". Mol. Biochem. Parasitol. 167 (1): 48–53. doi:10.1016/j.molbiopara.2009.04.006. PMID 19393693. 
• Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations.". Transfusion. 48 (6): 1164–8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676. 
• Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture.". J. Soc. Gynecol. Investig. 13 (3): 181–5. doi:10.1016/j.jsgi.2006.02.002. PMID 16638588. 
• Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.". Respiratory physiology & neurobiology. 161 (2): 111–8. doi:10.1016/j.resp.2007.12.007. PMID 18280225. 
• Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine.". Biochem. Biophys. Res. Commun. 373 (4): 613–7. doi:10.1016/j.bbrc.2008.06.086. PMID 18601899. 
• Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.". Biochem. Biophys. Res. Commun. 387 (3): 564–8. doi:10.1016/j.bbrc.2009.07.077. PMID 19619514. 
• Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy. 61 (9): 1132–7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518. 
• Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin.". J. Invest. Dermatol. 128 (3): 542–8. doi:10.1038/sj.jid.5701047. PMID 17943189. 
• Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine.". Int J Environ Res Public Health. 5 (2): 115–9. doi:10.3390/ijerph5020115. PMC 2694936. PMID 18678926. 
• Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line.". J. Biol. Chem. 281 (27): 18401–7. doi:10.1074/jbc.M601266200. PMID 16672223. 
• Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.". J. Mol. Med. 86 (2): 221–31. doi:10.1007/s00109-007-0272-4. PMID 17968524. 
• Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis.". Arch. Dermatol. Res. 301 (3): 245–52. doi:10.1007/s00403-009-0927-9. PMC 3582396. PMID 19184071. 
• Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate.". Int. J. Urol. 14 (12): 1088–92; discussion 1092. doi:10.1111/j.1442-2042.2007.01901.x. PMID 18036046. 
• Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin.". J. Cell. Biochem. 102 (4): 1051–8. doi:10.1002/jcb.21350. PMID 17471492. 
• Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.". J. Cell. Physiol. 217 (2): 338–49. doi:10.1002/jcp.21506. PMID 18543247. 
• Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc.". J. Mol. Histol. 39 (3): 303–9. doi:10.1007/s10735-008-9166-1. PMID 18247144. 
• Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells.". Stem Cells. 23 (7): 992–1001. doi:10.1634/stemcells.2004-0197. PMID 16043462. 
• Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.". J. Membr. Biol. 208 (1): 55–64. doi:10.1007/s00232-005-0819-7. PMID 16596446. 
• Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues.". Hum. Pathol. 38 (1): 171–8. doi:10.1016/j.humpath.2006.07.015. PMID 17056099. 

External links

• GIL blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
• Human AQP3 genome location and AQP3 gene details page in the UCSC Genome Browser.

UpToDate Contents

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• 1. 羊水量調節の生理学 physiology of amniotic fluid volume regulation
• 2. 赤血球細胞膜：構造、機構、動態 red blood cell membrane structure organization and dynamics
• 3. 腹膜透析における溶質クリアランスおよび限外濾過の機序 mechanisms of solute clearance and ultrafiltration in peritoneal dialysis
• 4. 羊水過少 oligohydramnios

English Journal

• Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3.

• Wu Z1, Uchi H2, Morino-Koga S3, Shi W4, Furue M5.
• Journal of dermatological science.J Dermatol Sci.2014 Jul;75(1):16-23. doi: 10.1016/j.jdermsci.2014.03.004. Epub 2014 Mar 25.
• BACKGROUND: Aquaporin 3 (AQP3) is the predominant aquaporin in the skin and is overexpressed in hyperplastic epidermal disorders. Upregulation of AQP3 contributes to keratinocyte proliferation and epidermal hyperplasia. Resveratrol, a natural polyphenol, has an anti-proliferative effect on normal hu
• PMID 24726500

• Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.

• Chaudhuri RK1, Bojanowski K.
• International journal of cosmetic science.Int J Cosmet Sci.2014 Jun;36(3):221-30. doi: 10.1111/ics.12117. Epub 2014 Mar 6.
• OBJECTIVE: The study was undertaken to compare the skin care related activities of retinol and bakuchiol, a potential alternative to retinoids. Retinol is a pivotal regulator of differentiation and growth of developing as well as adult skin. Retinoic acid is the major physiologically active metaboli
• PMID 24471735

• miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.

• Jiang B1, Li Z, Zhang W, Wang H, Zhi X, Feng J, Chen Z, Zhu Y, Yang L, Xu H, Xu Z.
• Journal of gastroenterology.J Gastroenterol.2014 Jun;49(6):1011-25. doi: 10.1007/s00535-013-0851-9. Epub 2013 Jun 26.
• BACKGROUND: Aquaporin-3 (AQP3) is a water transporting protein which plays an oncogenic role in several malignant tumors. However, its regulatory mechanism remains elusive to date. In this study, we investigated the microRNA-mediated gene repression mechanism involved in AQP3's role.METHODS: The pot
• PMID 23800944

Japanese Journal

• Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis

• PLoS ONE 12(2), e0171880, 2017-02-15
• NAID 120005997131

• Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

• PLOS ONE 12(2), 2017-02-07
• NAID 120005980864

• 血液脳関門障害の機序解明から血管性認知症の予防と治療に向けて

• 臨床神経学 57(3), 95-109, 2017
• NAID 130005494231

Related Links

• AQP3 aquaporin 3 (Gill blood group) [ (human)]

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the ...

• AQP3 - Aquaporin-3 - Homo sapiens (Human) - AQP3 gene ...

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol ...

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リンク元	「アクアポリン3」「AQP3」

「アクアポリン3」

　　[★]

英

aquaporin 3、AQP3

同

アクアポリン-3、水チャネルアクアポリン-3

関

アクアポリン

• 主に腎集合管の側底膜に存在する水チャネル

「AQP3」

　　[★] アクアポリン3 aquaporin 3