WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
produce specks in or on; "speck the cloth"
a very small spot; "the plane was just a speck in the sky" (同)pinpoint

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1. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
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5. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Kaiser WJ1, Daley-Bauer LP2, Thapa RJ3, Mandal P2, Berger SB4, Huang C2, Sundararajan A2, Guo H2, Roback L2, Speck SH2, Bertin J4, Gough PJ5, Balachandran S3, Mocarski ES1.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 May 27;111(21):7753-8. doi: 10.1073/pnas.1401857111. Epub 2014 May 12.
The pronecrotic kinase, receptor interacting protein (RIP1, also called RIPK1) mediates programmed necrosis and, together with its partner, RIP3 (RIPK3), drives midgestational death of caspase 8 (Casp8)-deficient embryos. RIP1 controls a second vital step in mammalian development immediately after b
PMID 24821786

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.

Lee BC1, Lee J2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1842(3):446-62. doi: 10.1016/j.bbadis.2013.05.017. Epub 2013 May 22.
There is increasing evidence showing that inflammation is an important pathogenic mediator of the development of obesity-induced insulin resistance. It is now generally accepted that tissue-resident immune cells play a major role in the regulation of this obesity-induced inflammation. The roles that
PMID 23707515

Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model.

Liu HD1, Li W, Chen ZR, Hu YC, Zhang DD, Shen W, Zhou ML, Zhu L, Hang CH.
Neurochemical research.Neurochem Res.2013 Oct;38(10):2072-83. doi: 10.1007/s11064-013-1115-z. Epub 2013 Jul 28.
Inflammatory response plays an important role in the pathogenesis of secondary damage after traumatic brain injury (TBI). The inflammasome is a multiprotein complex involved in innate immunity and a number of studies have suggested that the inflammasome plays a critical role in a host inflammatory s
PMID 23892989

Hasegawa Mizuho,Imamura Ryu,Motani Kou,Nishiuchi Takumi,Matsumoto Norihiko,Kinoshita Takeshi,Suda Takashi
Journal of immunology 182(12), 7655-7662, 2009-06-15
… Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor molecule that mediates inflammatory and apoptotic signals. …
NAID 120001450993

Hasegawa Mizuho,Kawase Kouji,Inohara Naohiro,Imamura Ryu,Yeh Wen-Chen,Kinoshita Takeshi,Suda Takashi
Oncogene Volume 26(12), 1748-1756, 2007-03-15
… Apoptosis-associated speck-like protein containing a CARD (ASC) is an adaptor molecule that mediates apoptotic and inflammatory signals, and implicated in tumor suppression. … Here, we investigated the molecular mechanisms of ASC-mediated apoptosis in several cell lines using a caspase recruitment domain 12-Nod2 chimeric protein that transduces the signal from muramyl dipeptide into ASC-mediated apoptosis. …
NAID 120001133297