UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing.

Fernandez-Moure JS1, Van Eps JL2, Cabrera FJ3, Barbosa Z4, Medrano Del Rosal G3, Weiner BK5, Ellsworth WA 4th6, Tasciotti E3.
The Journal of surgical research.J Surg Res.2017 Jan;207:33-44. doi: 10.1016/j.jss.2016.08.063. Epub 2016 Aug 26.
Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, an
PMID 27979486

Middleton E1,2, Rondina MT1,2,3.
Hematology. American Society of Hematology. Education Program.Hematology Am Soc Hematol Educ Program.2016 Dec 2;2016(1):256-261.
Sepsis is a dynamic, acute, infectious disease syndrome characterized by dysregulated thrombo-inflammatory responses. The high mortality associated with sepsis has been recognized since the earliest clinicians' writings. Despite this, advances in the treatment of sepsis have been more modest. This i
PMID 27913489

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.

Xu XR1,2,3, Zhang D2,3, Oswald BE2,4,5, Carrim N1,2,4, Wang X2,6, Hou Y2,7, Zhang Q2,8, Lavalle C2,5, McKeown T2, Marshall AH2, Ni H1,2,4,5,9.
Critical reviews in clinical laboratory sciences.Crit Rev Clin Lab Sci.2016 Dec;53(6):409-30. doi: 10.1080/10408363.2016.1200008. Epub 2016 Jul 22.
Platelets are small anucleate blood cells generated from megakaryocytes in the bone marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet adhesion, activation and aggregation constitute the first wave of hemostasis. Blood coagulation, which is initiated by th
PMID 27282765

岡野こずえ
山口医学 = Yamaguchi medical journal 64(1), 5-9, 2015-02
… されていない.現在,我々は血液中の多様なMPの中でもaPLT-MPを特異的に定量出来る高感度ELISAを開発し,種々の血栓症患者を対象に臨床的有用性の検討に取り組んでいる.さらに,aPLT-MP以外のMP検出法を開発し,各細胞由来MPが血栓形成作用や炎症促進作用にどのように関与しているかをaPLT-MPとの比較で明らかにする研究を行っている.今回はその研究経過について報告する.A platelet is a discoid and anucleate microcytic cell of diameter …
NAID 120005601210

Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.

Nakagawa Yosuke,Nakamura Sou,Nakajima Masahiro,Endo Hiroshi,Dohda Takeaki,Takayama Naoya,Nakauchi Hiromitsu,Arai Fumihito,Fukuda Toshio,Eto Koji
Experimental hematology 41(8), 742-748, 2013-08
… Although the safety of iPSC derivation has not been completely validated, anucleate cells, such as platelets or erythrocytes, derived from iPSCs are promising targets. …
NAID 120005312061