Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/05 01:42:17」(JST)

wiki en

Anti-streptolysin O (ASO or ASLO) is the antibody made against streptolysin O, an immunogenic, oxygen-labile hemolytic toxin produced by most strains of group A and many strains of groups C and G streptococci. The O in the name stands for oxygen-labile; the other related toxin being oxygen-stable streptolysin-S. The main function of streptolysin O is to cause hemolysis (the breaking open of red blood cells) in particular, beta-hemolysis.

Clinical significance[edit]

When the body is infected with streptococci, it produces antibodies against the various antigens that the streptococci produce. ASO is one such antibody. A raised or rising levels can indicate past or present infection. Historically it was one of the first bacterial markers used for diagnosis and follow up of rheumatic fever or scarlet fever. Its importance in this regard has not diminished.

Since these antibodies are produced as a delayed antibody reaction to the above mentioned bacteria, there is no normal value. The presence of these antibodies indicates an exposure to these bacteria. However, as many people are exposed to these bacteria and remain asymptomatic, the mere presence of ASO does not indicate disease.

Acceptable values, where there is no clinical suspicion of rheumatism are as follows:

Adults: less than 200 units
Children: less than 400 units

This titre has a significance only if it is greatly elevated (>200), or if a rise in titre can be demonstrated in paired blood samples taken days apart.The antibody levels begin to rise after 1 to 3 weeks of strep infection, peaks in 3 to 5 weeks and falls back to insignificant levels in 6 months. ';'; Values need to be correlated with a clinical diagnosis.

Estimation[edit]

For more details on this topic, see serology.

It is done by serological methods like latex agglutination or slide agglutination. ELISA may be performed to detect the exact titre value.

To detect the titre value, by a non-ELISA method, one has to perform the above agglutination using a serial dilution technique.

Mechanism of action[edit]

For more details on this topic, see rheumatic fever.

These antibodies produced against the bacteria cross-react with human antigens (mainly collagen) and hence attack the cellular matrix of various organs, mainly the heart, joints, skin, brain, etc.

Antistreptolysin O titre[edit]

Antistreptolysin O titre (AS(L)O titre or AS(L)OT) is a measure of the blood plasma levels of antistreptolysin O antibodies used in tests for the diagnosis of a streptococcal infection or indicate a past exposure to streptococci.

The ASOT helps direct antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever, and post infectious glomerulonephritis.

A positive test usually is >200 units/mL,^[1] but normal ranges vary from laboratory to laboratory and by age.^[2]

The false negatives rate is 20-30%.^[1] If a false negative is suspected, then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.^[1]

References[edit]

^ ^a ^b ^c Antistreptococcal antibody titres. gpnotebook. URL: http://www.gpnotebook.co.uk/cache/-1630535637.htm. Accessed on: March 31, 2007.
^ Danchin M, Carlin J, Devenish W, Nolan T, Carapetis J (2005). "New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children". J Paediatr Child Health 41 (11): 583–6. doi:10.1111/j.1440-1754.2005.00726.x. PMID 16398843.

External links[edit]

Antistreptococcal antibody titres - GPnotebook.co.uk.
Antistreptolysin O Titer - medterms.com.
Antistreptolysin O Titer, Serum
Streptococcal antibody tests - healthAtoZ.com

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 急性リウマチ熱の臨床症状および診断 clinical manifestations and diagnosis of acute rheumatic fever
2. 成人における急性咽頭炎の評価 evaluation of acute pharyngitis in adults
3. 小児における溶連菌感染後糸球体腎炎 poststreptococcal glomerulonephritis in children
4. A群レンサ球菌：病原性因子および発症機序 group a streptococcus virulence factors and pathogenic mechanisms
5. 結節性紅斑 erythema nodosum

English Journal

Neutrophilic urticarial dermatosis: a novel association with poststreptococcal rheumatic disease.

Salam A1, Papalexopoulou N2, White JM1, Martin B1, Coakley G3, McGibbon DH1.
Clinical and experimental dermatology.Clin Exp Dermatol.2017 Dec 22. doi: 10.1111/ced.13344. [Epub ahead of print]
PMID 29271002

Serpiginous Purpuric Eruption of the Leg.

Totoraitis K, Magro CM, Friedman A.
Journal of drugs in dermatology : JDD.J Drugs Dermatol.2017 Oct 1;16(10):1036-1038.
A previously healthy 68-year-old male presented with a rash on his right lower leg. The lesions had spread along the leg since onset 9 days prior, and the patient reported localized soreness and pruritus. He denied systemic symptoms including fever, fatigue, myalgia, joint pain, and recent illness.
PMID 29036258

Immuno-nephelometric determination of group streptococcal anti-streptolysin O titres (ASOT) from dried blood spots: Method for validating a new assay.

Joseph J1, Kent N2, Bowen A3, Hart J2, Sheel M4, Wardrop R5, Abbs S2, Bazely S6, Rybak M2.
Journal of immunological methods.J Immunol Methods.2017 Sep;448:59-65. doi: 10.1016/j.jim.2017.05.009. Epub 2017 May 26.
PMID 28554544

Japanese Journal

高血圧，浮腫，著明な肝脾腫で発症した腎外症候性溶連菌感染後急性糸球体腎炎の１例

日本小児腎臓病学会雑誌 30(1), 48-53, 2017
NAID 130006789712

Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I

Internal Medicine 55(6), 647-650, 2016
NAID 130005138060

A Case of Adult-Onset Acute Rheumatic Fever With Long-Lasting Atrioventricular Block Requiring Permanent Pacemaker Implantation

International Heart Journal 56(6), 664-667, 2015
NAID 130005113057

Related Pictures

antistreptolysin o Anti Streptolysin O(ASO) anti streptolysin o aso or aslo 은 ASO (Anti-Streptolysin-O) Serology kit Anti Streptolysin O (ASO) Test: Principle Antistreptolysin O titer. Causes, symptoms Antistreptolysin O Titeration