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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/26 07:05:17」(JST)
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An antimycobacterial is a type of drug used to treat Mycobacteria infections.
Types include:
- Tuberculosis treatments
- Leprostatic agents
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
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Nucleic acid inhibitor |
Rifamycins/
RNA polymerase inhibitor |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifalazil§
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Antifolates/DSI |
- Dapsone#
- Acedapsone
- Aldesulfone sodium
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ASA |
- 4-Aminosalicylic acid# (Calcium aminosalicylate
- Sodium aminosalicylate)
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Protein synthesis inhibitor |
Aminoglycosides |
- Amikacin#
- Capreomycin#
- Kanamycin#
- Streptomycin#
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Oxazolidone |
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Cell envelope antibiotic |
Peptidoglycan layer |
- Alanine analogue: Cycloserine#
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Arabinogalactan layer |
- Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
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Mycolic acid layer |
- Hydrazides/mycolic acid synth. inhibition: Isoniazid#
- Thiocarbamides: Ethionamide#
- Prothionamide
- Thiocarlide
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Other/unknown |
- Phenazine (Clofazimine)#
- Pyrazine (Pyrazinamide#, Morinamide)
- Isoxazole (Terizidone)
- Bedaquiline
- Metronidazole (delamanid)
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Combinations |
- Rifampicin/isoniazid/pyrazinamide
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
- Wang JF1, He WJ2, Zhang XX2, Zhao BQ2, Liu YH3, Zhou XJ4.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Oct 1;25(19):4082-4. doi: 10.1016/j.bmcl.2015.08.034. Epub 2015 Aug 18.
- A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11(13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis
- PMID 26316467
- One-pot synthesis of new triazole-Imidazo[2,1-b][1,3,4]thiadiazole hybrids via click chemistry and evaluation of their antitubercular activity.
- Ramprasad J1, Nayak N1, Dalimba U2, Yogeeswari P3, Sriram D3.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Oct 1;25(19):4169-73. doi: 10.1016/j.bmcl.2015.08.009. Epub 2015 Aug 8.
- A new series of triazole-imidazo[2,1-b][1,3,4]thiadiazole hybrids (6a-s, 7a) were designed by a molecular hybridisation approach and the target molecules were synthesized via one pot click chemistry protocol. All the intermediates and final molecules were characterised using spectral methods and one
- PMID 26298500
- Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens.
- Peraman R1, Varma RV2, Reddy YP3.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Oct 1;25(19):4314-9. doi: 10.1016/j.bmcl.2015.07.071. Epub 2015 Aug 1.
- Occurrence of antibacterial and antimycobacterial resistance stimulated a thrust to discover new drugs for infectious diseases. Herein we report the work on re-engineering nalidixic acid's chemical scaffold for newer leads. Stepwise clubbing of quinoxaline, 1,2,4-triazole/1,3,4-oxadiazole with nalid
- PMID 26277407
Japanese Journal
- 胸腔鏡下肺葉切除術による空洞病変切除後に,対側肺空洞病変の縮小をみた肺非結核性抗酸菌症の1例
- Synthesis, <i>in Vitro</i> and <i>in Silico</i> Studies of Some Novel 5-Nitrofuran-2-yl Hydrazones as Antimicrobial and Antitubercular Agents
- Synthesis, <i>in vitro</i> and <i>in silico</i> studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents
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- Analysis PDF Word Power Point Ebook Antimycobacterial Synthesis, Antimycobacterial, Antifungal and Photosynthesis Book 2 MB | Ebook Pages: 175 Molecules 2010, 15, 8567-8581; doi:10.3390/molecules15128567 molecules ...
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