English Journal
- Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?
- McLennan AG.SourceInstitute of Integrative Biology, University of Liverpool, Biosciences Building, Crown St., Liverpool, L69 7ZB, UK, agmclen@liv.ac.uk.
- Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2013 Feb;70(3):373-85. doi: 10.1007/s00018-012-1210-3. Epub 2012 Nov 27.
- Many members of the nudix hydrolase family exhibit considerable substrate multispecificity and ambiguity, which raises significant issues when assessing their functions in vivo and gives rise to errors in database annotation. Several display low antimutator activity when expressed in bacterial teste
- PMID 23184251
- Emergence of DNA Polymerase {epsilon} Antimutators that Escape Error-Induced Extinction in Yeast.
- Williams LN, Herr AJ, Preston BD.SourceUniversity of Washington.
- Genetics.Genetics.2013 Jan 10. [Epub ahead of print]
- DNA polymerases (Pols) ε and δ perform the bulk of yeast leading- and lagging-strand DNA synthesis. Both Pols possess intrinsic proofreading exonucleases that edit errors during polymerization. Rare errors that elude proofreading are extended into duplex DNA and excised by the mismatch repair (M
- PMID 23307893
- Interrelationship between HIV-1 Fitness and Mutation Rate.
- Dapp MJ, Heineman RH, Mansky LM.SourceInstitute for Molecular Virology, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA; Pharmacology Graduate Program, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
- Journal of molecular biology.J Mol Biol.2013 Jan 9;425(1):41-53. doi: 10.1016/j.jmb.2012.10.009. Epub 2012 Oct 16.
- Differences in replication fidelity, as well as mutator and antimutator strains, suggest that virus mutation rates are heritable and prone to natural selection. Human immunodeficiency virus type 1 (HIV-1) has many distinct advantages for the study of mutation rate optimization given the wealth of st
- PMID 23084856
Japanese Journal
- Effect of Escherichia coli dnaE antimutator mutants on mutagenesis by the base anolog N^4-aminocytidine
- SCHAAPER R. M.
- Mutat. Res. 402, 23-28, 1998
- NAID 30005173189
- Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity
- CAI J. P.
- Nucleic Acids Res. 25, 1170-1176, 1997
- NAID 30018405964
- A small, stable RNA induced by oxidative stress : role as a pleiotropic regulator and antimutator
- ALTUVIA S.
- Cell 90, 43-53, 1997
- NAID 30010693671
Related Links
- F igure 1. Locations of mutations in the bacteriophage T4 DNA polymerase gene that confer mutator and antimutator phenotypes. More comprehensive listings of N-terminal mutator mutations and C-terminal ...
- An antimutator lowers mutation rate. An increased level of nuclease activity (editing function) and all other genetic repair mechanisms may act this way. Compounds that inactivate microsomal enzymes involved in conversion of ...
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