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- 1. 化学療法の血管外漏出による傷害およびその他の非抗腫瘍薬による水疱extravasation injury from chemotherapy and other non antineoplastic vesicants [show details]
…receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to emtansine, a highly cytotoxic antimicrotubule agent, has been classified as an irritant; however, a single case report of skin necrosis following…
- 2. 化学療法による脱毛chemotherapy induced alopecia [show details]
…(cyclophosphamide, ifosfamide), antitumor antibiotics (dactinomycin, doxorubicin, idarubicin), antimicrotubule agents (paclitaxel, docetaxel, ixabepilone, eribulin), and topoisomerase inhibitors (etoposide…
- 3. HER2陽性転移性乳癌の全身治療systemic treatment for her2 positive metastatic breast cancer [show details]
…as T-DM1) is an antibody-drug conjugate composed of trastuzumab, a thioether linker, and the antimicrotubule agent, DM1. Lapatinib – Lapatinib is a tyrosine kinase inhibitor against EGFR1 and HER2 that…
- 4. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要overview of neurologic complications of non platinum cancer chemotherapy [show details]
…International website . The drug is usually shipped overnight. Paclitaxel and docetaxel are antimicrotubule agents that are used to treat a variety of tumors. Both are associated with a predominantly sensory …
- 5. HER2陽性乳癌患者への術前補助療法neoadjuvant therapy for patients with her2 positive breast cancer [show details]
…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate composed of trastuzumab linked to a potent antimicrotubule agent (emtansine) that is released only after the drug is internalized into the HER2-positive…
English Journal
- +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules.
- Thomas GE, Sreeja JS, Gireesh KK, Gupta H, Manna TK.
- International journal of oncology.Int J Oncol.2015 Jan;46(1):133-46. doi: 10.3892/ijo.2014.2701. Epub 2014 Oct 7.
- Microtubule plus‑end‑binding protein (+TIP) EB1 has been shown to be upregulated in breast cancer cells and promote breast tumor growth in vivo. However, its effect on the cellular actions of microtubule‑targeted drugs in breast cancer cells has remained poorly understood. By using cellular
- PMID 25310526
- Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using t1-weighted and t2-weighted cardiovascular magnetic resonance.
- Jordan JH1, D'Agostino RB Jr1, Hamilton CA1, Vasu S1, Hall ME1, Kitzman DW1, Thohan V1, Lawrence JA1, Ellis LR1, Lash TL1, Hundley WG2.
- Circulation. Cardiovascular imaging.Circ Cardiovasc Imaging.2014 Nov;7(6):872-9. doi: 10.1161/CIRCIMAGING.114.002217. Epub 2014 Oct 1.
- BACKGROUND: In a murine anthracycline-related cardiotoxicity model, increases in cardiovascular magnetic resonance myocardial contrast-enhanced T1-weighted signal intensity are associated with myocellular injury and decreases with left ventricular ejection fraction. We sought to determine whether T1
- PMID 25273568
- Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
- Hayashi Y1, Takeno H1, Chinen T2, Muguruma K1, Okuyama K3, Taguchi A1, Takayama K1, Yakushiji F1, Miura M4, Usui T2, Hayashi Y1.
- ACS medicinal chemistry letters.ACS Med Chem Lett.2014 Jul 23;5(10):1094-8. doi: 10.1021/ml5001883. eCollection 2014.
- A new benzophenone-diketopiperazine-type potent antimicrotubule agent was developed by modifying the structure of the clinical candidate plinabulin (1). Although the right-hand imidazole ring with a branched alkyl chain at the 5-position in 1 was critical for the potency of the antimicrotubule activ
- PMID 25313318
Japanese Journal
- An Effective Click Strategy for Water-soluble Prodrugs of the Antimicrotubule Agent 'Plinabulin'
- Peptide science : proceedings of the ... Japanese Peptide Symposium 2012, 7-8, 2013-03-01
- NAID 10031161527
- Medicinal Chemistry and Chemical Biology of Diketopiperazine-Type Antimicrotubule and Vascular-Disrupting Agents
- Fission Yeast Pot1 and RecQ Helicase Are Required for Efficient Chromosome Segregation
Related Links
- An antimicrotubule agent is a type of drug that blocks cell growth by stopping mitosis (cell division). Antimicrotubule agents interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat ...
- An antimicrotubule agent is a type of drug that blocks cell growth by stopping mitosis (cell division). Antimicrotubule agents interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat ...
★リンクテーブル★
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- 英
- antimicrotubule
- 関
- 微小管阻害
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- 英
- antimicrotubule
- 関
- 微小管毒