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1. 造血細胞移植後の再発の予防および治療のための免疫療法 immunotherapy for the prevention and treatment of relapse following hematopoietic cell transplantation
2. 成人における急性リンパ芽球性白血病に対する造血細胞移植の一般原則 general principles of hematopoietic cell transplantation for acute lymphoblastic leukemia in adults
3. 血液悪性腫瘍を有する成人における侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adults with hematologic malignancies
4. 慢性リンパ性白血病患者における感染症リスク risk of infections in patients with chronic lymphocytic leukemia
5. 小児および思春期における急性リンパ芽球性白血病のリスクグループ層別化および予後 risk group stratification and prognosis for acute lymphoblastic leukemia in children and adolescents

English Journal

Torelli GF1, Peragine N1, Mariglia P1, Foà R1.
Immunotherapy.Immunotherapy.2016 Apr;8(4):425-34. doi: 10.2217/imt-2015-0009.
The antileukemic potential of natural killer (NK) cells has over the years raised considerable interest and new immune-based treatment protocols characterized by the infusion of freshly isolated or ex vivo activated and expanded effectors have been designed. Several aspects still need to be addresse
PMID 26973124

Kooltheat N1, Kamuthachad L1, Anthapanya M1, Samakchan N1, Sranujit RP2, Potup P1, Ferrante A3, Usuwanthim K4.
Nutrition (Burbank, Los Angeles County, Calif.).Nutrition.2016 Apr;32(4):486-90. doi: 10.1016/j.nut.2015.10.010. Epub 2015 Oct 30.
OBJECTIVES: Although kaffir lime has been reported to exhibit antioxidant and antileukemic activity, little is known about the antimicrobial effect of kaffir lime extract. Because Streptococcus mutans has been known to cause biofilm formation, it has been considered the most important causative path
PMID 26743975

Saccharomyces cerevisiae asparaginase II, a potential antileukemic drug: Purification and characterization of the enzyme expressed in Pichia pastoris.

Facchinetti de Castro Girão L1, Gonçalves da Rocha SL2, Sobral RS3, Dinis Ano Bom AP4, Franco Sampaio AL5, Godinho da Silva J Jr4, Ferrara MA6, Pinto da Silva Bon E7, Perales J8.
Protein expression and purification.Protein Expr Purif.2016 Apr;120:118-25. doi: 10.1016/j.pep.2015.12.012. Epub 2015 Dec 20.
Asparaginase obtained from Escherichia coli and Erwinia chrysanthemi are used to treat acute lymphocytic leukaemia and non-Hodgkin's lymphoma. However, these agents cause severe adverse effects. Saccharomyces cerevisiae asparaginase II, encoded by the ASP3 gene, could be a potential candidate for th
PMID 26714301

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

Sari Dina Permata,Ninomiya Masayuki,Efdi Mai,Santoni Adlis,Ibrahim Sanusi,Tanaka Kaori,Koketsu Mamoru
Journal of Oleo Science 62(10), 843-848, 2013
Polyalthia is a versatile genus of shrubs and trees found in tropic and sub-tropic regions. In this study, three clerodane diterpenes, kolavenic acid (1), polyalthialdoic acid (2), and 16α-hydroxy-cle …
NAID 130004435993

門脇則光,北脇年雄
Drug Delivery System 28(1), 10-16, 2013
近年の免疫学の発展と有望な腫瘍関連抗原の同定により、白血病に対する化学療法後の免疫療法によって、微小残存病変を駆逐する可能性が開かれつつある。白血病に対する免疫療法の手法として、ペプチドワクチン、GM-CSF遺伝子導入腫瘍細胞ワクチン、樹状細胞ワクチン、T細胞養子免疫療法が試みられている。これらにより、免疫反応の誘導と一定の臨床効果が示されているが、親和性の高いT細胞療法では重篤な副作用も報告され …
NAID 130003368331