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1. 薬物療法の最新情報 whats new in drug therapy
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English Journal

Photo-controllable molecular hydrogels for drug delivery.

Liu H, Song Z, Chen X.
Journal of nanoscience and nanotechnology.J Nanosci Nanotechnol.2014 Jul;14(7):4837-42.
A photocleavable nitrobenzyl ester group was introduced in the backbone of self-assembling peptides using standard Fmoc-peptide systhesis. The nitrobenzyl ester group could be used as a cleavable linker to connect a gelator and a hydrophilic group. Photo-irradiation would lead to the generation of t
PMID 24757951

Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.

Brackett J1, Schafer ES, Leung DH, Bernhardt MB.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Jun;61(6):1114-7. doi: 10.1002/pbc.24913. Epub 2013 Dec 27.
Mercaptopurine (6-MP), a critical component of acute lymphoblastic leukemia (ALL) therapy, is metabolized to 6-thioguanine (6-TGN) which is responsible for its anti-leukemic effect, and to 6-methylmercaptopurine nucleotides (6-MMPN/6-MMP) which can be hepatotoxic. Some patients preferentially metabo
PMID 24376133

FMF50: a score for assessing outcome in familial Mediterranean fever.

Ozen S1, Demirkaya E, Duzova A, Erdogan O, Erken E, Gul A, Kasapcopur O, Kasifoglu T, Kisacik B, Ozdogan H, Tunca M, Acikel C; FMF Arthritis Vasculitis and Orphan disease Research in pediatric rheumatology (FAVOR) and Turkish FMF study group.
Annals of the rheumatic diseases.Ann Rheum Dis.2014 May;73(5):897-901. doi: 10.1136/annrheumdis-2013-204719. Epub 2014 Feb 25.
BACKGROUND: Colchicine is the main treatment for familial Mediterranean fever (FMF). However, biological agents and other treatments are available for patients who are unable to receive optimal treatment.OBJECTIVE: To develop outcome criteria that define response to treatment.METHODS: Two rounds of
PMID 24570027

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