抗カルジオリピン抗体
WordNet
- any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
PrepTutorEJDIC
- 抗体,免疫体,抗毒素
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/11 22:45:32」(JST)
[Wiki en表示]
schematic representation of antibody.
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis,[1] antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome,[2] idiopathic spontaneous abortion,[3] and systemic lupus erythematosus (SLE).[4] They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of antibodies act independently.[5] This is in contrast to rheumatoid arthritis[6] with systemic sclerosis (scleroderma)[7] because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together.
Anti-cardiolipin antibodies can be classified in two ways:
- As IgM, IgG or IgA
- As β2-glycoprotein dependent or independent
- In autoimmune disease ACA are beta-2 glycoprotein dependent
- syphilis ACA[1] are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test
Apolipoprotein H involvement
β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[8] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
References
- ^ a b Tringali GR, Julian AJ, Halbert WM (1969). "Effect of 2-mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors". The British journal of venereal diseases 45 (3): 202–4. doi:10.1136/sti.45.3.202. PMC 1048465. PMID 5346419.
- ^ Hull RG, Harris EN, Gharavi AE, et al. (1984). "Anticardiolipin antibodies: occurrence in Behçet's syndrome". Ann. Rheum. Dis. 43 (5): 746–748. doi:10.1136/ard.43.5.746. PMC 1001520. PMID 6497467.
- ^ Petri M, Golbus M, Anderson R, Whiting-O'Keefe Q, Corash L, Hellmann D (1987). "Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. A controlled, prospective study of forty-four women". Arthritis Rheum. 30 (6): 601–606. doi:10.1002/art.1780300601. PMID 3111489.
- ^ Harris EN, Gharavi AE, Boey ML, et al. (1983). "Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus". Lancet 2 (8361): 1211–1214. doi:10.1016/S0140-6736(83)91267-9. PMID 6139567.
- ^ Harris EN, Gharavi AE, Loizou S, et al. (1985). "Crossreactivity of antiphospholipid antibodies". Journal of clinical & laboratory immunology 16 (1): 1–6. PMID 3981615.
- ^ Keane A, Woods R, Dowding V, Roden D, Barry C (1987). "Anticardiolipin antibodies in rheumatoid arthritis". Br. J. Rheumatol. 26 (5): 346–350. doi:10.1093/rheumatology/26.5.346. PMID 3664159.
- ^ Malia RG, Greaves M, Rowlands LM, et al. (1988). "Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations". Clin. Exp. Immunol. 73 (3): 456–60. PMC 1541778. PMID 2974767.
- ^ McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. Natl. Acad. Sci. U.S.A. 87 (11): 4120–4124. doi:10.1073/pnas.87.11.4120. PMC 54059. PMID 2349221.
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Medical test: Antibodies: autoantibodies
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| Anti-nuclear antibody |
- PBC:
- Anti-gp210
- Anti-p62
- Anti-sp100
- ENA:
- Anti-topoisomerase/Scl-70
- Anti-Jo1
- ENA4
- Anti-Sm
- Anti-nRNP
- Anti-Ro
- Anti-La
|
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| Anti-mitochondrial antibody |
|
|
| Anti-cytoplasm antibody |
- Anti-neutrophil cytoplasmic
- Anti-smooth muscle
- Anti-TPO/Antimicrosomal
|
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| Cell membrane |
- Anti-ganglioside
- Anti-GBM
- Anti-glutamate
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| Extracellular |
- Anti-thrombin
- Lupus anticoagulant
- Coeliac disease:
- Anti-transglutaminase
- Anti-gliadin not autoantibody
- RA
- Rheumatoid factor/anti-IgG
- Anti-citrullinated peptide
|
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| Multiple locations |
- Anti-phospholipid
- Anti-apolipoprotein
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UpToDate Contents
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- 1. 抗リン脂質抗体症候群の診断 diagnosis of the antiphospholipid syndrome
- 2. 抗リン脂質抗体症候群の臨床症状 clinical manifestations of the antiphospholipid syndrome
- 3. 抗リン脂質抗体症候群の治療 treatment of the antiphospholipid syndrome
- 4. 抗リン脂質抗体症候群の病因 pathogenesis of the antiphospholipid syndrome
- 5. 不育症の男女の評価 evaluation of couples with recurrent pregnancy loss
English Journal
- My contribution, my dream - a look at the future of APS.
- Koike T.
- Lupus.Lupus.2014 Oct;23(12):1332-4. doi: 10.1177/0961203314534306.
- We found, in 1994, that the epitope for anticardiolipin antibodies (aCL) developed when β2-glycoprotein I (β2GPI) was adsorbed on polyoxygenated polystyrene plates. We also found, in 2009, that the cleaved form of β2GPI (nicked β2GPI) was bound to angiostatin 4.5 and attenuated its antiangiogeni
- PMID 25228741
- Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies.
- Romay-Penabad Z1, Carrera Marin A1, Willis R1, Weston-Davies W2, Machin S3, Cohen H3, Brasier A1, Gonzalez E4.
- Lupus.Lupus.2014 Oct;23(12):1324-6. doi: 10.1177/0961203314546022.
- Activation of the complement cascade is an important mechanism for antiphospholipid antibody-mediated thrombosis. We examined the effects of rEV576 (coversin), a recombinant protein inhibitor of complement factor 5 activation, on antiphospholipid antibody-mediated tissue factor up-regulation and thr
- PMID 25228739
- Toll-like receptor 4 and β2 glycoprotein I interaction on endothelial cells.
- Borghi M1, Raschi E2, Grossi C2, Chighizola C1, Meroni P3.
- Lupus.Lupus.2014 Oct;23(12):1302-4. doi: 10.1177/0961203314536479.
- Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic events and/or pregnancy morbidity in the persistent presence of antiphospholipid antibodies (aPL). aPL targeting β2 glycoprotein I (anti-β2GPI Abs) provide the main pathogenic autoantibody subset. In monoc
- PMID 25228733
Japanese Journal
- 奥 健志,アメングアル オルガ,久田 諒,大村 一将,中川 育麿,渡邊 俊之,坊垣 暁之,堀田 哲也,保田 晋助,渥美 達也
- 日本臨床免疫学会会誌 38(3), 157-163, 2015
- 抗リン脂質抗体症候群（APS）に出現する病原性自己抗体である抗リン脂質抗体（aPL）は免疫学的にも機能的にも多様な自己抗体群で，それらをどのように効率的・正確に同定するかはいまだに重大な問題である．更に，aPLの測定には多数の免疫学的・機能的検査が必要であり，検査部門の負担が大きく必要十分な検査が行われない事が多い．そこで，北海道大学病院内科IIおよび消化器内科，北海道医療大学内科に通院するA …
- NAID 130005089221
- Seronegative Antiphospholipid Syndrome with Anti-phosphatidylethanolamine Antibody in a Boy
- Asano Takeshi,Narazaki Hidehiko,Kaizu Kiyohiko,Kuwabara Kentaroh,Fujino Osamu,Itoh Yasuhiko
- Journal of Nippon Medical School 82(2), 117-120, 2015
- … At our institution, APS is diagnosed on the basis of the Sapporo criteria, which consist of thrombosis and recurrent pregnancy-related complications and the following laboratory findings: the presence of lupus anticoagulant, anticardiolipin antibody, or anti-β2 glycoprotein 1 antibody. …
- NAID 130005068461
- 臨床報告 急速に失明した抗リン脂質抗体症候群に伴う片眼性網膜中心動静脈閉塞症の1例
Related Links
- The quantitative measurement of anticardiolipin (aCL) antibody is important in diagnosing antiphospholipid syndrome (APS). According to the Second International Anti-cardiolipin Standardization Workshop, the reference ...
- Also known as: Anticardiolipin Antibodies; aCL Antibody Formal name: Cardiolipin Antibodies (IgG, IgM, and IgA) Related tests: Antiphospholipid Antibodies; Beta-2 Glycoprotein 1 Antibodies; Anti-phosphatidylserine; ; At a ...
★リンクテーブル★
[★]
- 英
- anticardiolipin antibody, anti-cardiolipin antibody
- 関
- カルジオリピン cardiolipin
[★]
- 関
- cardiolipin