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1. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
2. 分子標的薬である血管新生阻害剤の毒性：心血管系以外への影響 toxicity of molecularly targeted antiangiogenic agents non cardiovascular effects
3. 分子標的薬である血管新生阻害剤の毒性：心血管系への影響 toxicity of molecularly targeted antiangiogenic agents cardiovascular effects
4. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤感受性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum sensitive disease
5. 乳房肉腫：治療 breast sarcoma treatment

English Journal

Conditionally replicating oncolytic adenoviral vector expressing arresten and tumor necrosis factor-related apoptosis-inducing ligand experimentally suppresses lung carcinoma progression.

Li S1, Qi Z2, Li H2, Hu J2, Wang D3, Wang X2, Feng Z3.
Molecular medicine reports.Mol Med Rep.2015 Aug;12(2):2068-74. doi: 10.3892/mmr.2015.3624. Epub 2015 Apr 16.
Current methods of treatment for lung carcinoma are ineffective for the majority of patients. Conditionally replicating adenoviruses (CRAds) represent a potential novel treatment for a number of neoplastic diseases, including lung carcinoma. The present study aimed to investigate the synergistic mec
PMID 25891208

Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells.

Ren J1, Huang Q, Xu Y, Yang M, Yang J, Hu K.
Anti-cancer drugs.Anticancer Drugs.2015 Jul;26(6):599-611. doi: 10.1097/CAD.0000000000000224.
Isoflavones constitute a large series of compounds found in many plants. They make up an important part of the diet and have a broad spectrum of biological activities such as cytotoxic and antitumor effects. Lupiwighteone (Lup) is an isoflavone-type compound. It is distributed widely in wild-growing
PMID 25734831

Amniotic membrane and adipose-derived stem cell co-culture system enhances bone regeneration in a rat periodontal defect model.

Wu PH1, Chung HY2, Wang JH3, Shih JC4, Kuo MY2, Chang PC2, Huang Y5, Wang PC6, Chang CC7.
Journal of the Formosan Medical Association = Taiwan yi zhi.J Formos Med Assoc.2015 Jun 11. pii: S0929-6646(15)00094-7. doi: 10.1016/j.jfma.2015.02.002. [Epub ahead of print]
BACKGROUND/PURPOSE: Periodontal disease is a chronic inflammatory process that potentially leads to alveolar bone destruction and tooth loss. Tissue engineering combined with stem cell therapy is a potential effective treatment for periodontal bone loss. Amniotic membrane (AM) is a potential scaffol
PMID 26073611

A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication

Hossen Md. Nazir,Kajimoto Kazuaki,Akita Hidetaka,Hyodo Mamoru,Harashima Hideyoshi
Journal of controlled release 171(2), 104-112, 2013-10-28
… Antiangiogenesis has been the focus of a new strategy for the treatment of obesity. …
NAID 120005365904

Shota Tanaka,Andrew S. Chi,Patrick Y. Wen,David N. Louis,A. John Iafrate,Tracy T. Batchelor
脳神経外科ジャーナル = Japanese journal of neurosurgery 22(8), 590-596, 2013-08-20
従来の放射線化学療法をもってしても予後不良である神経膠芽腫に対する新たな治療として, 分子標的薬が注目されている. 腫瘍発生・進展の分子生物学的メカニズムが明らかになるにつれ, さまざまな薬剤が開発され臨床治験が行われてきた. しかし腫瘍細胞内シグナル伝達異常の多様性などのため, 高い奏効率を示し認可に至った分子標的薬はいまだない. 神経膠芽腫という組織学的診断のみでなく, ターゲットシークエン …
NAID 10031178582